Definition of out-of-plane fragility curves for masonry infills subject to combined in-plane and out-of-plane damage

The paper presents the outcomes of a probabilistic assessment framework aimed at defining out-of-plane fragility curves of unreinforced masonry infills walls which have been subjected (or not) prior in-plane damage. A recently developed in-plane (IP)/out-of-plane (OOP) four-strut macro-element model is used to model masonry infills within frames. Out-of-plane incremental dynamic analyses are performed, for a reference infilled frame, based on a suite of 26 ground motion record selection. Peak ground acceleration (PGA) and OOP relative displacement of the midspan node of the infill, are used as intensity measure and damage measure. The outcomes show fragility curves representing the probability of exceeding out-of-plane collapse at a given earthquake intensity as a function of a different combination of geometrical and mechanical parameters, in-plane damage level and supporting conditions. Results are finally summarized by curves relating in-plane interstorey drifts and out-of-plane average collapse PG

Statistics on Logic Simulation

The high costs associated with logic simulation of large VLSI based systems have led to the need for new computer architectures tailored to the simulation task. Such architecture have the potential for significant speedups over standard software based logic simulators. Several commercial simulation engines have been produced to satisfy need in this area. To properly explore the space of alternative simulation architectures, data is required on the simulation process itself. This paper presents a framework for such data gathering activity by first examining possible sources of speedup in the logic simulation task, examining the sort of data needed in the design of simulation engines, and then presenting such data. The data contained in the paper includes information on the subtask times found in standard discrete event simulation algorithms, event intensities, queue length distributions and simultaneous event distributions

Simulating Radiating and Magnetized Flows in Multi-Dimensions with ZEUS-MP

This paper describes ZEUS-MP, a multi-physics, massively parallel, message- passing implementation of the ZEUS code. ZEUS-MP differs significantly from the ZEUS-2D code, the ZEUS-3D code, and an early "version 1" of ZEUS-MP distributed publicly in 1999. ZEUS-MP offers an MHD algorithm better suited for multidimensional flows than the ZEUS-2D module by virtue of modifications to the Method of Characteristics scheme first suggested by Hawley and Stone (1995), and is shown to compare quite favorably to the TVD scheme described by Ryu et. al (1998). ZEUS-MP is the first publicly-available ZEUS code to allow the advection of multiple chemical (or nuclear) species. Radiation hydrodynamic simulations are enabled via an implicit flux-limited radiation diffusion (FLD) module. The hydrodynamic, MHD, and FLD modules may be used in one, two, or three space dimensions. Self gravity may be included either through the assumption of a GM/r potential or a solution of Poisson's equation using one of three linear solver packages (conjugate-gradient, multigrid, and FFT) provided for that purpose. Point-mass potentials are also supported. Because ZEUS-MP is designed for simulations on parallel computing platforms, considerable attention is paid to the parallel performance characteristics of each module. Strong-scaling tests involving pure hydrodynamics (with and without self-gravity), MHD, and RHD are performed in which large problems (256^3 zones) are distributed among as many as 1024 processors of an IBM SP3. Parallel efficiency is a strong function of the amount of communication required between processors in a given algorithm, but all modules are shown to scale well on up to 1024 processors for the chosen fixed problem size.Comment: Accepted for publication in the ApJ Supplement. 42 pages with 29 inlined figures; uses emulateapj.sty. Discussions in sections 2 - 4 improved per referee comments; several figures modified to illustrate grid resolution. ZEUS-MP source code and documentation available from the Laboratory for Computational Astrophysics at http://lca.ucsd.edu/codes/currentcodes/zeusmp2

Nanoantennas for visible and infrared radiation

Nanoantennas for visible and infrared radiation can strongly enhance the interaction of light with nanoscale matter by their ability to efficiently link propagating and spatially localized optical fields. This ability unlocks an enormous potential for applications ranging from nanoscale optical microscopy and spectroscopy over solar energy conversion, integrated optical nanocircuitry, opto-electronics and density-ofstates engineering to ultra-sensing as well as enhancement of optical nonlinearities. Here we review the current understanding of optical antennas based on the background of both well-developed radiowave antenna engineering and the emerging field of plasmonics. In particular, we address the plasmonic behavior that emerges due to the very high optical frequencies involved and the limitations in the choice of antenna materials and geometrical parameters imposed by nanofabrication. Finally, we give a brief account of the current status of the field and the major established and emerging lines of investigation in this vivid area of research.Comment: Review article with 76 pages, 21 figure

Dismissive and deceptive car dealerships create barriers to electric vehicle adoption at the point of sale

This study investigates the role of car dealerships in the electrification of passenger transport, namely their sales advice about the purchase and use of electric vehicles (EVs). Because most consumers do not have pre-existing knowledge of EVs, and current market conditions favour petrol and diesel vehicles, car dealership experiences may strongly influence EV purchasing decisions. Here we show that car dealerships pose a significant barrier at the point of sale due to a perceived lack of business case viability in relation to petrol and diesel vehicles. In 126 shopping experiences at 82 car dealerships across Denmark, Finland, Iceland, Norway, and Sweden, we find dealers were dismissive of EVs, misinformed shoppers on vehicle specifications, omitted EVs from the sales conversation and strongly oriented customers towards petrol and diesel vehicle options. Dealer’s technological orientation, willingness to sell, and displayed knowledge of EVs were the main contributors to likely purchase intentions. These findings combined with expert interviews suggest that government and industry signalling affect sales strategies and purchasing trends. Policy and business strategies that address barriers at the point of sale are needed to accelerate EV adoption

Atomic-scale confinement of optical fields

In the presence of matter there is no fundamental limit preventing confinement of visible light even down to atomic scales. Achieving such confinement and the corresponding intensity enhancement inevitably requires simultaneous control over atomic-scale details of material structures and over the optical modes that such structures support. By means of self-assembly we have obtained side-by-side aligned gold nanorod dimers with robust atomically-defined gaps reaching below 0.5 nm. The existence of atomically-confined light fields in these gaps is demonstrated by observing extreme Coulomb splitting of corresponding symmetric and anti-symmetric dimer eigenmodes of more than 800 meV in white-light scattering experiments. Our results open new perspectives for atomically-resolved spectroscopic imaging, deeply nonlinear optics, ultra-sensing, cavity optomechanics as well as for the realization of novel quantum-optical devices

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

The slow-releasing hydrogen sulfide (H2S) donor, GYY4137, caused concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38) as determined by trypan blue exclusion. Sodium hydrosulfide (NaHS) was less potent and not active in all cell lines. A structural analogue of GYY4137 (ZYJ1122) lacking sulfur and thence not able to release H2S was inactive. Similar results were obtained using a clonogenic assay. Incubation of GYY4137 (400 µM) in culture medium led to the generation of low (<20 µM) concentrations of H2S sustained over 7 days. In contrast, incubation of NaHS (400 µM) in the same way led to much higher (up to 400 µM) concentrations of H2S which persisted for only 1 hour. Mechanistic studies revealed that GYY4137 (400 µM) incubated for 5 days with MCF-7 but not IMR90 cells caused the generation of cleaved PARP and cleaved caspase 9, indicative of a pro-apoptotic effect. GYY4137 (but not ZYJ1122) also caused partial G2/M arrest of these cells. Mice xenograft studies using HL-60 and MV4-11 cells showed that GYY4137 (100–300 mg/kg/day for 14 days) significantly reduced tumor growth. We conclude that GYY4137 exhibits anti-cancer activity by releasing H2S over a period of days. We also propose that a combination of apoptosis and cell cycle arrest contributes to this effect and that H2S donors should be investigated further as potential anti-cancer agents

The electromagnetic Christodoulou memory effect and its application to neutron star binary mergers

Gravitational waves are predicted by the general theory of relativity. It has been shown that gravitational waves have a nonlinear memory, displacing test masses permanently. This is called the Christodoulou memory. We proved that the electromagnetic field contributes at highest order to the nonlinear memory effect of gravitational waves, enlarging the permanent displacement of test masses. In experiments like LISA or LIGO which measure distances of test masses, the Christodoulou memory will manifest itself as a permanent displacement of these objects. It has been suggested to detect the Christodoulou memory effect using radio telescopes investigating small changes in pulsar’s pulse arrival times. The latter experiments are based on present-day technology and measure changes in frequency. In the present paper, we study the electromagnetic Christodoulou memory effect and compute it for binary neutron star mergers. These are typical sources of gravitational radiation. During these processes, not only mass and momenta are radiated away in form of gravitational waves, but also very strong magnetic fields are produced and radiated away. Moreover, a large portion of the energy is carried away by neutrinos. We give constraints on the conditions, where the energy transported by electromagnetic radiation is of similar or slightly higher order than the energy radiated in gravitational waves or in form of neutrinos. We find that for coalescing neutron stars, large magnetic fields magnify the Christodoulou memory as long as the gaseous environment is sufficiently rarefied. Thus the observed effect on test masses of a laser interferometer gravitational wave detector will be enlarged by the contribution of the electromagnetic field. Therefore, the present results are important for the planned experiments. Looking at the null asymptotics of spacetimes, which are solutions of the Einstein–Maxwell equations, we derive the electromagnetic Christodoulou memory effect. We obtain an exact solution of the full nonlinear problem, no approximations were used. Moreover, our results allow to answer astrophysical questions, as the knowledge about the amount of energy radiated away in a neutron star binary merger enables us to gain information about the source of the gravitational waves.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98597/1/0264-9381_29_21_215003.pd

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

EIT Observations of the Extreme Ultraviolet Sun

The Extreme Ultraviolet Imaging Telescope (EIT) on board the SOHO spacecraft has been operational since 2 January 1996. EIT observes the Sun over a 45 x 45 arc min field of view in four emission line groups: Feix, x, Fexii, Fexv, and Heii. A post-launch determination of the instrument flatfield, the instrument scattering function, and the instrument aging were necessary for the reduction and analysis of the data. The observed structures and their evolution in each of the four EUV bandpasses are characteristic of the peak emission temperature of the line(s) chosen for that bandpass. Reports on the initial results of a variety of analysis projects demonstrate the range of investigations now underway: EIT provides new observations of the corona in the temperature range of 1 to 2 MK. Temperature studies of the large-scale coronal features extend previous coronagraph work with low-noise temperature maps. Temperatures of radial, extended, plume-like structures in both the polar coronal hole and in a low latitude decaying active region were found to be cooler than the surrounding material. Active region loops were investigated in detail and found to be isothermal for the low loops but hottest at the loop tops for the large loops