32 research outputs found
Ultrasonic tissue characterization defines the specific role of elastin in maintaining aortic structural integrity and compliance
Intraoperative evaluation of myocardial revascularization during minimally invasive direct coronary artery bypass by means of ultrasonic integrated backscatter
Data from: Changes in left ventricular relaxation after azelnidipine treatment in hypertensive patients with diabetes: subanalysis of a prospective single-arm multicenter study
Objectives: We previously demonstrated that a calcium channel blocker, azelnidipine, improves left ventricular relaxation in patients with hypertension and diastolic dysfunction in a multicentre, Clinical impact of Azelnidipine on Left VentricuLar diastolic function and OutComes in patients with hypertension (CALVLOC) trial. The objectives of the present subanalysis were to investigate the differences in diastolic function in hypertensive patients with and without diabetes, and the efficacy of azelnidipine on diastolic function among them. Design: Subanalysis of a prospective single-arm multicentre study. Participants: 228 hypertensive patients with normal ejection fraction and impaired left ventricular relaxation (septal e′ velocity <8 cm/s on echocardiography) enrolled for CALVLOC trial. They were divided into two groups based on presence or absence of diabetes. Interventions: Administration of 16 mg of azelnidipine for 8 months (range 6–10 months). Main outcome measures: Septal e′ velocity before and at the end of the study. Results: Whereas patients with diabetes (n=53, 23.2%) had lower systolic blood pressure (BP) than patients without diabetes (155±17 vs 161±16 mm Hg, p=0.03), they had lower e′ velocity (5.7±1.5 vs 6.1±1.4 cm/s, p=0.04) at baseline. Azelnidipine decreased BP and heart rate, and increased e′ velocity similarly in patients with diabetes (5.7±1.5 to 6.3±1.5 cm/s, p=0.0003) and without diabetes (6.1±1.4 to 6.9±1.4 cm/s, p<0.0001). Increase in e′ velocity was not influenced by presence of diabetes, and patients with diabetes still had lower e′ velocity after treatment (p=0.006). There was a significant correlation between increase in e′ velocity and decrease in systolic BP (R=0.25, p=0.0001), which was not influenced by diabetes. Conclusions: Comorbid diabetes could impair left ventricular relaxation independently in patients with hypertension, which might not be improved solely by BP lowering
Clinical Implications of Assessing Coronary Flow Velocity Reserve and Plasma Endothelin-1 in Hypertensive Patients
Single Nucleotide Polymorphisms in the Interleukin-6 Gene Associated with Blood Pressure and Atherosclerosis in a Japanese General Population
Collected data from the origial CALVLOC study
An Excel file containing the original data of CALVLOC study (Hypertens Res. 2009;32:895-900), from which we perfomed the present subanalysis.
Abbreviations used in the colums headings; BP, blood pressure; HR, heart rate; LVDd/LVDs, end-diastolic and end-systoic LV diameters; IVSth, intraventricular septum thickness; PWth, posterior wall thickness; RWT, relative wall thickness