Morphology and oil quality of introduced olive cultivars (Olea europaea L.) in southwest China

There are enormous benefits of olive cultivation in China. However, rare researches are reported about the morphological and oil qualitative characteristics of the introduced olive cultivars in southwest China. The characteristics of morphological and oil qualitative were investigated among seven introduced olive cultivars and an indigenous cultivar cultivated in southwest China. The results elucidated that all cultivars had adapted to a new environment and expressed unique characteristics. The Coratina, Koroneiki and Grossanne remained excellent oil cultivars with the fresh oil content of 20.42, 18.58 and 16.46%, respectively. The free acidity and peroxide value of olive oil were within the range of the extra virgin olive oil category. And the extracted olive oil was rich in unsaturated fatty acid, α-tocopherol, squalene, stigmasterol, β-sitosterol and phenolic compounds. Moreover, the olive cultivated in southwest China exhibited a higher content of moisture, oleic acid and unsaturated fatty acid compared to scientific studies. Therefore, the region of southwest China (Jintang), a new environment, was a potential for cultivation and development of olive in the future. In addition, the results can provide theoretical guidance for olive planting and cultivar selection in southwest China

Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy

Endothelial dysfunction is an early pathological event in diabetic angiopathy which is the most common complication of diabetes. This study aims to investigate individual and combined actions of Curcumin (Cur) and Baicalein (Bai) in protecting vascular function. The cellular protective effects of Cur, Bai and Cur+Bai (1:1, w/w) were tested in H2O2 (2.5 mM) impaired EA. hy926 cells. Wistar rats were treated with vehicle control as the control group, Goto-Kakizaki rats (n=5 each group) were treated with vehicle control (model group), Cur (150 mg/kg), Bai (150 mg/kg), or Cur+Bai (75 mg/kg Cur + 75 mg/kg Bai, OG) for 4 weeks after a four-week high-fat diet to investigate the changes on blood vessel against diabetic angiopathy. Our results showed that Cur+Bai synergistically restored the endothelial cell survival and exhibited greater effects on lowering the fasting blood glucose and blood lipids in rats comparing to individual compounds. Cur+Bai repaired the blood vessel structure in the aortic arch and mid thoracic aorta. The network pharmacology analysis showed that Nrf2 and MAPK/JNK kinase were highly relevant to the multi-targeted action of Cur+Bai which has been confirmed in the in vitro and in vivo studies. In conclusion, Cur+Bai demonstrated an enhanced activity in attenuating endothelial dysfunction against oxidative damage and effectively protected vascular function in diabetic angiopathy rats

Modulation of vascular reactivity by perivascular adipose tissue (PVAT)

Purpose of Review: In this review we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/inflammation. Recent Findings: PVAT possesses an relevant endocrine-paracrine activity, which may be altered in several pathophysiological and clinical conditions. During the last two decades it has been shown PVAT may modulate vascular reactivity. It has also been previously demonstrated that inflammation in adipose tissue may be implicated in vascular dysfunction. In particular, adipocytes secrete a number of adipokines with various functions, as well as several vasoactive factors, together with components of the renin-angiotensin system which may act at local or at systemic level. It has been shown that the anticontractile effect of PVAT is lost in obesity, probably as a consequence of the development of adipocyte hypertrophy, inflammation, and oxidative stress. Summary: Adipose tissue dysfunction is interrelated with inflammation and oxidative stress, thus contributing to endothelial dysfunction observed in several pathological and clinical conditions such as obesity and hypertension. Decreased local adiponectin level, macrophage recruitment and infiltration, and activation of renin-angiotensin-aldosterone system could play an important role in this regards

Understanding the effects of solvents on the hydrogenation of toluene over supported Pd and Ru catalysts

The effects of solvents (n-hexane, isopropanol (IPA), tetrahydrofuran (THF) and methanol) on the hydrogenation of toluene over the Pd/SiO2 and Ru/SiO2 catalysts were studied. Microcalorimetric adsorption and IR spectroscopy were employed to understand the effects. It was found that n-hexane adsorbed weakly on the catalysts and thus affected less the hydrogenation of toluene, while THF and methanol adsorbed strongly on the catalysts and inhibited the activity of hydrogenation of toluene significantly. IPA also adsorbed strongly on the catalysts, but it exhibited a hydrogen transfer effect on the surfaces that promoted the conversion of toluene

Location-Based End-to-End Speech Recognition with Multiple Language Models

End-to-End deep learning approaches for Automatic Speech Recognition (ASR) has been a new trend. In those approaches, starting active in many areas, language model can be considered as an important and effective method for semantic error correction. Many existing systems use one language model. In this paper, however, multiple language models (LMs) are applied into decoding. One LM is used for selecting appropriate answers and others, considering both context and grammar, for further decision. Experiment on a general location-based dataset show the effectiveness of our method

A novel heterozygous splice-altering mutation in HFM1 may be a cause of premature ovarian insufficiency

Abstract Background Premature ovarian insufficiency (POI) leads to early loss of ovarian function in women aged  A) associated with POI was identified by whole-exome sequencing. This mutation was heterozygous in the affected family members and was absent in the unaffected family members. In silico analysis predicted that the mutation was potentially pathogenic. Bioinformatic splice prediction tools revealed that the mutation was very likely to have a strong impact on splice site function. Results of the minigene assay revealed that the mutation changed the mRNA splicing repertory. Conclusions The missense mutation of the HFM1 gene (c.3470G > A) may be a cause of POI. The mutation altered mRNA splicing in cells. This study can provide geneticists with deeper insight into the pathogenesis of POI and aid clinicians in making early diagnoses in affected women

Adverse drug reactions of non-statin antihyperlipidaemic drugs in China from 1989 to 2019: a national database analysis

Objective This study aims to understand the adverse drug reactions (ADRs) for non-statin antihyperlipidaemic drugs included in the China Anti-hyperlipidemic Drug Database.Design An approach of Chinese national database analysis was employed to screen clinical trials involving non-statin antihyperlipidaemic drugs from 1989 to 2019.Setting The database was provided by the China National Medical Products Administration Information Centre.Participants In total, 117 clinical studies with 8800 patients were selected from 2650 clinical trials of the Anti-hyperlipidemic Drug Database.Interventions The non-statin antihyperlipidaemic drugs were divided into three groups: (1) fibrates (fenofibrate, gemfibrozil, bezafibrate, etofylline clofibrate); (2) nicotinic acid and derivatives (niacin, acipimox) and (3) others (probucol, cholestyramine).Results The results of this study show that first, gastrointestinal symptoms were the most common reactions (6.975%), which account for approximately 50% of the reported cases with ADRs. Second, cholestyramine (16.418%) and gemfibrozil (13.158%) were the most common gastrointestinal side effect-causing non-statin antihyperlipidaemic drugs, which account for one-third of the population. Third, niacin (7.879%) and gemfibrozil (5.000%) were the most likely cause of liver disease symptoms. Finally, niacin (10.909%) and acipimox (18.847%) were the major non-statin antihyperlipidaemic drugs with skin symptoms.Conclusion This study revealed that gastrointestinal symptoms were the most common ADRs of fibrates, probucol and cholestyramine in the Chinese population. For nicotinic acid and derivatives, the ADRs of skin symptoms were the most common in China