151 research outputs found
Active Galaxies in the UV
In this article we present different aspects of AGN studies demonstrating the
importance of the UV spectral range. Most important diagnostic lines for
studying the general physical conditions as well as the metalicities in the
central broad line region in AGN are emitted in the UV. The UV/FUV continuum in
AGN excites not only the emission lines in the immediate surrounding but it is
responsible for the ionization of the intergalactic medium in the early stages
of the universe. Variability studies of the emission line profiles of AGN in
the UV give us information on the structure and kinematics of the immediate
surrounding of the central supermassive black hole as well as on its mass
itself.Comment: 29 pages, 13 figures, Ap&SS in pres
Photoconductance Quantization in a Single-Photon Detector
We have made a single-photon detector that relies on photoconductive gain in
a narrow electron channel in an AlGaAs/GaAs 2-dimensional electron gas. Given
that the electron channel is 1-dimensional, the photo-induced conductance has
plateaus at multiples of the quantum conductance 2e/h. Super-imposed on
these broad conductance plateaus are many sharp, small, conductance steps
associated with single-photon absorption events that produce individual
photo-carriers. This type of photoconductive detector could measure a single
photon, while safely storing and protecting the spin degree of freedom of its
photo-carrier. This function is valuable for a quantum repeater that would
allow very long distance teleportation of quantum information.Comment: 4 pages, 4 figure
Towards a New Standard Model for Black Hole Accretion
We briefly review recent developments in black hole accretion disk theory,
emphasizing the vital role played by magnetohydrodynamic (MHD) stresses in
transporting angular momentum. The apparent universality of accretion-related
outflow phenomena is a strong indicator that large-scale MHD torques facilitate
vertical transport of angular momentum. This leads to an enhanced overall rate
of angular momentum transport and allows accretion of matter to proceed at an
interesting rate. Furthermore, we argue that when vertical transport is
important, the radial structure of the accretion disk is modified at small
radii and this affects the disk emission spectrum. We present a simple model
demonstrating how energetic, magnetically-driven outflows modify the emergent
disk emission spectrum with respect to that predicted by standard accretion
disk theory. A comparison of the predicted spectra against observations of
quasar spectral energy distributions suggests that mass accretion rates
inferred using the standard disk model may severely underestimate their true
values.Comment: To appear in the Fifth Stromlo Symposium Proceedings special issue of
ApS
Supermassive Black Hole Binaries: The Search Continues
Gravitationally bound supermassive black hole binaries (SBHBs) are thought to
be a natural product of galactic mergers and growth of the large scale
structure in the universe. They however remain observationally elusive, thus
raising a question about characteristic observational signatures associated
with these systems. In this conference proceeding I discuss current theoretical
understanding and latest advances and prospects in observational searches for
SBHBs.Comment: 17 pages, 4 figures. To appear in the Proceedings of 2014 Sant Cugat
Forum on Astrophysics. Astrophysics and Space Science Proceedings, ed.
C.Sopuerta (Berlin: Springer-Verlag
Quasars and their host galaxies
This review attempts to describe developments in the fields of quasar and
quasar host galaxies in the past five. In this time period, the Sloan and 2dF
quasar surveys have added several tens of thousands of quasars, with Sloan
quasars being found to z>6. Obscured, or partially obscured quasars have begun
to be found in significant numbers. Black hole mass estimates for quasars, and
our confidence in them, have improved significantly, allowing a start on
relating quasar properties such as radio jet power to fundamental parameters of
the quasar such as black hole mass and accretion rate. Quasar host galaxy
studies have allowed us to find and characterize the host galaxies of quasars
to z>2. Despite these developments, many questions remain unresolved, in
particular the origin of the close relationship between black hole mass and
galaxy bulge mass/velocity dispersion seen in local galaxies.Comment: Review article, to appear in Astrophysics Update
How to move ionized gas: an introduction to the dynamics of HII regions
This review covers the dynamic processes that are important in the evolution
and structure of galactic HII regions, concentrating on an elementary
presentation of the physical concepts and recent numerical simulations of HII
region evolution in a non-uniform medium.
The contents are as follows:
(1) The equations (Euler equations; Radiative transfer; Rate equations; How
to avoid the dynamics; How to avoid the atomic physics).
(2) Physical concepts (Static photoionization equilibrium; Ionization front
propagation; Structure of a D-type front; Photoablation flows; Other
ingredients - Stellar winds, Radiation pressure, Magnetic fields,
Instabilities).
(3) HII region evolution (Early phases: hypercompact and ultracompact
regions; Later phases: compact and extended regions; Clumps and turbulence).Comment: To be published as a chapter in 'Diffuse Matter from Star Forming
Regions to Active Galaxies' - A volume Honouring John Dyson. Eds. T. W.
Harquist, J. M. Pittard and S. A. E. G. Falle. 25 pages, 7 figures. Some
figures degraded to meet size restriction. Full-resolution version available
at http://www.ifront.org/wiki/Dyson_Festschrift_Chapte
Parental origin of sequence variants associated with complex diseases
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldEffects of susceptibility variants may depend on from which parent they are inherited. Although many associations between sequence variants and human traits have been discovered through genome-wide associations, the impact of parental origin has largely been ignored. Here we show that for 38,167 Icelanders genotyped using single nucleotide polymorphism (SNP) chips, the parental origin of most alleles can be determined. For this we used a combination of genealogy and long-range phasing. We then focused on SNPs that associate with diseases and are within 500 kilobases of known imprinted genes. Seven independent SNP associations were examined. Five-one with breast cancer, one with basal-cell carcinoma and three with type 2 diabetes-have parental-origin-specific associations. These variants are located in two genomic regions, 11p15 and 7q32, each harbouring a cluster of imprinted genes. Furthermore, we observed a novel association between the SNP rs2334499 at 11p15 and type 2 diabetes. Here the allele that confers risk when paternally inherited is protective when maternally transmitted. We identified a differentially methylated CTCF-binding site at 11p15 and demonstrated correlation of rs2334499 with decreased methylation of that site.info:eu-repo/grantAgreement/EC/FP7/21807
Meta-analysis of type 2 Diabetes in African Americans Consortium
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)<P<5 × 10(-8), odds ratio (OR) = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2 × 10(-23) < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.Peer reviewe
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