Useful Field of View Impairment in Partial Epilepsy

Patients with epilepsy are at elevated risk for automobile crashes.Most collisions in drivers with epilepsy are not seizure-related, but may insteadresult from cognitive effects of epilepsy and antiepileptic drugs (AEDs) upondriving performance. The Useful Field of View (UFOV) score has demonstratedgood sensitivity and specificity for predicting automobile crashes. The goal in thispilot study was to assess impairments in the UFOV in subjects with partialepilepsy. Participants included 20 subjects with partial epilepsy. Neurologicallynormal control subjects of comparable age also participated. UFOV was assessedin all participants using the Visual Attention Analyzer, Model 3000 (VisualResources, Inc.). UFOV Task scores were added to calculate a UFOV Total scorefor each subject. UFOV scores were higher on all UFOV tasks in subjects withpartial epilepsy compared to neurologically normal individuals of similar age (p\u3c0.05, Wilcoxon Rank Sum Test), suggesting a greater crash risk in individualswith partial epilepsy, even in the absence of an epileptic seizure. Causes ofimpaired UFOV scores include processing speed reduction, divided and selectiveattention impairments, and mild postoperative visual field deficits. Our ongoingstudies in drivers with epilepsy are aimed at further differentiating potentialeffects of seizures, antiepileptic drugs, and surgical lesions upon cognitiveabilities that are critical to safe automobile driving

Hierarchical Co2P microspheres assembled from nanorods grown on reduced graphene oxide as anode material for Lithium-ion batteries

Transition metal phosphides (TMPs) have been studied as promising electrodes for energy storage and conversion due to their large theoretical capacities and high activities. Herein, a hierarchically structured Co2P coupling with the reduced graphene oxide (RGO) composite (Co2P/RGO) was synthesized by a simple solid state method for Li storage. The Co2P/RGO hybrid composite exhibits a high reversible capacity of 61 mAh g−1 at 60 mA g−1, good rate capability of 327 mAh g−1 at 3000 mA g−1 and long cycle life (397 mAh g−1 at 500 mA g−1 for after 1000 cycles). The excellent electrochemical performance can be attributed to the synergistic effect of Co2P micro/nano architecture and graphene modulation, which provide more activity sites for Li+-ions and maintain the structural integrity of active material. This work may provide a new path for preparation of other metal phosphides as potential electrode materials for application in energy storage fields

Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies

Adjustment factors of included studies. Figures S1. RR or RRR (female to male) of low alcohol intake and the risk of coronary disease. Figure S2. RR or RRR (female to male) of moderate alcohol intake and the risk of coronary disease. Figure S3. RR or RRR (female to male) of heavy alcohol intake and the risk of coronary disease. Figure S4. RR or RRR (female to male) of low alcohol intake and the risk of total mortality. Figure S5. RR or RRR (female to male) of moderate alcohol intake and the risk of total mortality. Figure S6. RR or RRR (female to male) of heavy alcohol intake and the risk of total mortality. Figure S7. RR or RRR (female to male) of low alcohol intake and the risk of ischemic stroke. Figure S8. RR or RRR (female to male) of low alcohol intake and the risk of cardiac death. Figure S9. RR or RRR (female to male) of low alcohol intake and the risk of stroke. Figure S10. RR or RRR (female to male) of moderate alcohol intake and the risk of cardiac death. Figure S11. RR or RRR (female to male) of moderate alcohol intake and the risk of stroke. Figure S12. RR or RRR (female to male) of moderate alcohol intake and the risk of ischemic stroke. Figure S13. RR or RRR (female to male) of heavy alcohol intake and the risk of cardiac death. Figure S14. RR or RRR (female to male) of heavy alcohol intake and the risk of stroke. Figure S15. RR or RRR (female to male) of heavy alcohol intake and the risk of ischemic stroke. Figure S16. Funnel plot of RRR (female to male) for low alcohol intake. Figure S17. Funnel plot of RRR (female to male) for moderate alcohol intake. Figure S18. Funnel plot of RRR (female to male) for heavy alcohol intake. (DOC 10344 kb

Associations between Statin/Omega3 Usage and MRI-Based Radiomics Signatures in Prostate Cancer

Prostate cancer is the most common noncutaneous cancer and the second leading cause of cancer deaths among American men. Statins and omega-3 are two medications recently found to correlate with prostate cancer risk and aggressiveness, but the observed associations are complex and controversial. We therefore explore the novel application of radiomics in studying statin and omega-3 usage in prostate cancer patients. On MRIs of 91 prostate cancer patients, two regions of interest (ROIs), the whole prostate and the peripheral region of the prostate, were manually segmented. From each ROI, 944 radiomic features were extracted after field bias correction and normalization. Heatmaps were generated to study the radiomic feature patterns against statin or omega-3 usage. Radiomics models were trained on selected features and evaluated with 500-round threefold cross-validation for each drug/ROI combination. On the 1500 validation datasets, the radiomics model achieved average AUCs of 0.70, 0.74, 0.78, and 0.72 for omega-3/prostate, omega- 3/peripheral, statin/prostate, and statin/peripheral, respectively. As the first study to analyze radiomics in relation to statin and omega-3 uses in prostate cancer patients, our study preliminarily established the existence of imaging-identifiable tissue-level changes in the prostate and illustrated the potential usefulness of radiomics for further exploring these medications’ effects and mechanisms in prostate cancer

Genomic and transcriptomic analysis identified gene clusters and candidate genes for oil content in peanut (Arachis hypogaea L.)

Peanut (Arachis hypogaea), a major source of vegetable oil in many Asian countries, has become an integral part of human diet globally due to its high nutritional properties and option to consume in different forms. In order to meet the demand of vegetable oil, many peanut breeding programs of China have intensified their efforts in increasing oil content in newly bred varieties for reducing the import of edible oils in China. In this context, transcriptome sequencing data generated on 49 peanut cultivars were analyzed to identify candidate genes and develop molecular markers for seed oil content across multiple environments. Transcriptome analysis identified 5458 differentially expressed genes (DEGs) including 2243 positive DEGs and 3215 negative DEGs involved in oil synthesis process. Genome-wide association study identified 48 significant insertion/deletion (InDel) markers associated with seed oil content across five environments. A comparative genomics and transcriptomics analysis detected a total of 147 common gene clusters located in 17 chromosomes. Interestingly, an InDel cluster associated with seed oil content on A03 chromosome was detected in three different environments. Candidate genes identified on A03 form a haplotype, in which variable alleles were found to be different in oil content in an independent population. This locus is important for understanding the genetic control of peanut oil content and may be useful for marker-assisted selection in peanut breeding programs

Antitumor agents 294. Novel E-ring-modified camptothecin–4β-anilino-4′-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents

Two conjugates (1 and 2) of camptothecin (CPT) and 4β-anilino-4′-O-demethylepipodophyllotoxin were previously shown to exert antitumor activity through inhibition of topoisomerase I (topo I). In this current study, two novel conjugates (1E and 2E) with an open E-ring in the CPT moiety were first synthesized and evaluated for biological activity in comparison with their intact E-ring congeners. This novel class of CPT derivatives exhibits its antitumor effect against CPT-sensitive and -resistant cells, in part, by inhibiting topo I-linked DNA (TLD) religation. An intact E-ring was not essential for the inhibition of TLD religation, although conjugates with an open E-ring were less potent than the closed ring analogs. This lower religation potency resulted in decreased formation of protein-linked DNA breaks (PLDBs), and hence, less cell growth inhibition. In addition to their impact on topo I, conjugates 1E, 2, and 2E exhibited a minor inhibitory effect on topo II-induced DNA cleavage. The novel structures of 1E and 2E may present scaffolds for further development of dual function topo I and II inhibitors with improved pharmacological profiles and physicochemical properties

Cryptopleurine Analogs with Modification of E Ring Exhibit Different Mechanism to Rac-Cryptopleurine and Tylophorine

Tylophorine analogs exhibit a broad range of pharmacological activities, including anti-cancer, anti-inflammatory, anti-autoimmune, and anti-virus effects. Structure-activity relationship study of different structure tylophorine analogs can provide further understanding of their biological activity. Modifications on the E ring of the quinolizidine moiety of cryptopleurine analogs changed the potency and the selective inhibitory effect on NF-κB, AP-1, and CRE signaling pathways. Functional cryptopleurine analogs showed potent inhibition of NF-κB signaling pathway in both HepG2 and HEK-293 cell lines. The E ring structure analogs also differed in suppression of protein translation, and expression of cyclin D1. Our results showed that DCB-3503 or Rac-cryptopleurine could be a scaffold for modification to yield compounds with different mechanisms of action

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents

Tetrahydroneotanshinlactone (TNT) and tetrahydronaphthalene-1-ol (TNO) derivatives were designed, synthesized, and evaluated for cytotoxic activity. The TNO derivatives were found to be a promising novel class of in vitro antitumor agents. The cyclohexene ring-A could dramatically affect the antitumor activity and selectivity. Compound 20 showed the highest potency with ED50 values of 0.7 and 1.7 µM against SK-BR-3 and ZR-75-1 breast cancer cell lines, respectively

Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents

6-Phenyl-4H-furo[3,2-c]pyran-4-one derivatives based on neo-tashinlactone (1) were synthesized and evaluated as novel anti-breast cancer agents. Compounds 10-13, 23, 25, and 27 showed potent inhibition against the SK-BR-3 breast cancer cell line. Importantly, 25 and 27 showed the highest cancer cell line selectivity, being approximately 100- to 250-fold more potent against SK-BR-3 (ED50 0.28 and 0.44 μM, respectively) compared with other cancer cell lines tested. In addition, 25 displayed low cytotoxicity against normal breast cell lines 184A1 and MCF10A. Compounds 25 and 27 merit further investigation in our continuing program to generate and develop selective anti-breast cancer agents

Genomic and Transcriptomic Analysis Identified Gene Clusters and Candidate Genes for Oil Content in Peanut (Arachis hypogaea L.)

Peanut (Arachis hypogaea), a major source of vegetable oil in many Asian countries, has become an integral part of human diet globally due to its high nutritional properties and option to consume in different forms. In order to meet the demand of vegetable oil, many peanut breeding programs of China have intensified their efforts in increasing oil content in newly bred varieties for reducing the import of edible oils in China. In this context, transcriptome sequencing data generated on 49 peanut cultivars were analyzed to identify candidate genes and develop molecular markers for seed oil content across multiple environments. Transcriptome analysis identified 5458 differentially expressed genes (DEGs) including 2243 positive DEGs and 3215 negative DEGs involved in oil synthesis process. Genome-wide association study identified 48 significant insertion/deletion (InDel) markers associated with seed oil content across five environments. A comparative genomics and transcriptomics analysis detected a total of 147 common gene clusters located in 17 chromosomes. Interestingly, an InDel cluster associated with seed oil content on A03 chromosome was detected in three different environments. Candidate genes identified on A03 form a haplotype, in which variable alleles were found to be different in oil content in an independent population. This locus is important for understanding the genetic control of peanut oil content and may be useful for marker-assisted selection in peanut breeding programs