73 research outputs found
SOCIAL INTERACTION OF LARGE BUSINESSES AS A SECURITY CONDITION OF ITS OPERATION AND DEVELOPMENT IN THE NORTHERN REGION
Purpose: The aim of the research is to identify social interaction of large businesses as a security condition of its operation and development in the northern region.
Methodology: This is descriptive-analytic research whose data are obtained through library studies and analytical resources. Data analysis is based on content analysis and analytical comparison.
Result: Results showed that to improve the safety of large businesses in the Northern region continuous socially-oriented activities aimed at improving the quality of life of the population of the region of presence with the support of various social initiatives in the region of presence are required.
Applications: This research can be used for businessmen and developers.
Novelty/Originality: In this research, the model of social interaction of large businesses is presented in a comprehensive and complete manner
Методи синтезу, будова та біологічна активність 5-нітро-9-N-ариламіноакридинів
With the purpose of search of new biologically active substances the synthesis of nine derivatives of 5-nitro-9-Narylaminoacridinium (2a-i) has been carried out by interaction of the corresponding 5-nitro-9-chloracridines and aromatic amines in two ways: in the phenol medium (method A) and in the dioxane medium in the presence of hydrochloric acid (method B). It has been experimentally proven that method B is more expedient because it is characterized by the absence of toxic phenol in the synthesis, reduction of the experiment time, a high yield of the desired product (87-94%). The structure and individuality of compounds synthesized that are undescribed in the literature have been confirmed by IR-, NMR-spectral and chromatographic analysis. The choice of the pharmacological screening spectrum has been conducted using data of PASS-prognosis, scientific and patent literature. It has been found experimentally that the substances synthesized possess a moderate bacteriostatic and fungistatic, expressed anti-inflammatory and analgesic, high diuretic (compounds 2d-f) and antidiuretic (compounds 2h-i) activities. According to the classification by K.K.Sydorov the compounds synthesized when introduced intragastrically belong to low toxic compounds. Some regularities of the “structure – biological activity – toxicity” dependence have been analyzed, and it is an important element in determining the areas for further research to develop new biologically active substances.С целью поиска новых малотоксичных биологически активных веществ осуществлен синтез девяти метоксизамещенных 5-нитро-9-N-ариламиноакридинив (2а-з) взаимодействием соответствующих 5-нитро-9-хлоракридинов с ароматическими аминами двумя способами: в среде фенола (способ А) и в среде диоксана в присутствии хлористоводородной кислоты (способ Б). Экспериментально доказано, что способ Б является более рациональным, так как для него характерны: легкость проведения синтеза, сокращение времени эксперимента, отсутствие в синтезе токсического фенола, высокий выход целевых продуктов (87-94%). Строение и индивидуальность неописанных в литературе синтезированных соединений подтверждены данными ИК-, ПМР-спектрального и хроматографического анализа. Выбор спектра фармакологического скрининга проводили, опираясь на данные PASS-прогноза, научной и патентной литературы. По результатам экспериментальных биологических исследований выявлено, что для синтезированных соединений (2а-з) характерна умеренная бактерио- и фунгистатическая, выраженная противовоспалительная и анальгетическая, высокая диуретическая (соединения 2г-е) и антидиуретическая (соединения 2ж-з) активность. По классификации К.К.Сидорова синтезированные вещества при внутрижелудочном введении относятся к классу малотоксичных соединений. Проанализированы некоторые закономерности связи «структура – биологическая активность – токсичность», что является важным элементом для определения направлений дальнейшей научной работы по созданию новых биологически активных субстанций.З метою пошуку нових малотоксичних біологічно активних речовин здійснено синтез дев’яти метоксизаміщених 5-нітро-9-N-ариламіноакридинів (2а-з) взаємодією відповідних 5-нітро-9-хлоракридинів з ароматичними амінами двома способами: у середовищі фенолу (спосіб А) та у середовищі діоксану в присутності хлористоводневої кислоти (спосіб Б). Експериментально доведено, що спосіб Б є більш раціональним, так як для нього характерні: легкість проведення синтезу, скорочення часу експерименту, відсутність у синтезі токсичного фенолу, високий вихід цільових продуктів (87-94%). Будову та індивідуальність неописаних у літературі синтезованих сполук підтверджено даними ІЧ-, ПМР-спектрального та хроматографічного аналізу. Вибір спектра фармакологічного скринінгу проводили, опираючись на дані PASS-прогнозу, наукової та патентної літератури. За результатами експериментальних біологічних досліджень виявлено, що для синтезованих сполук (2а-з) характерна помірна бактеріо- і фунгістатична, виражена протизапальна та аналгетична, висока діуретична (сполуки 2г-е) та антидіуретична (сполуки 2ж-з) активність. За класифікацією К.К.Сидорова синтезовані речовини при внутрішньошлунковому введенні належать до класу малотоксичних сполук. Проаналізовано деякі закономірності зв’язку «структура – біологічна активність – токсичність», що є важливим елементом для визначення напрямків подальшої наукової роботи по створенню нових біологічно активних субстанцій
Understanding hysteresis in carbon dioxide sorption in porous metal-organic frameworks
Two
new isostructural microporous coordination frameworks [Mn3(Hpdc)2(pdc)2] (1) and [Mg3(Hpdc)2(pdc)2] (2) (pdc2– = pyridine-2,4-dicarboxylate) showing
primitive cubic (pcu) topology have been prepared and
characterized. The pore aperture of the channels is too narrow for
the efficient adsorption of N2; however, both compounds
demonstrate substantially higher uptake of CO2 (119.9 mL·g–1 for 1 and 102.5 mL·g–1 for 2 at 195 K, 1 bar). Despite of their structural
similarities, 2 shows a typical reversible type I isotherm
for adsorption/desorption of CO2, while 1 features
a two-step adsorption process with a very broad hysteresis between
the adsorption and desorption curves. This behavior can be explained
by a combination of density functional theory calculations, sorption,
and X-ray diffraction analysis and gives insights into the further
development of new sorbents showing adsorption/desorption hysteresis
Rapid ecological change in the coastal zone of Lake Baikal (East Siberia): Is the site of the world\u27s greatest freshwater biodiversity in danger?
Ecological degradation of the benthic littoral zone is an emerging, urgent problem at Lake Baikal (East Siberia), the most species-rich lake on Earth. Within the last five years, multiple changes have occurred in the nearshore benthos where most of the lake\u27s endemic species reside. These changes include proliferation of benthic algae, deaths of snails and endemic sponges, large coastal wash-ups of dead benthic algae and macrophytes, blooms of toxin-producing benthic cyanobacteria, and inputs of industrial contaminants into parts of the lake. Some changes, such as massive coastal accumulations of benthic algae, are currently shared with the Laurentian Great Lakes (LGLs); however, the drivers of these changes differ between Lake Baikal and the LGLs. Coastal eutrophication from inputs of untreated sewage is causing problems at multiple sites in Lake Baikal, whereas in the LGLs, invasive dreissenid mussels redirect pelagic nutrients to the littoral substrate. At other locations in Lake Baikal, ecological degradation may have different causes including water level fluctuations and the input of toxic industrial contaminants. Importantly, the recent deterioration of the benthic littoral zone in both Lake Baikal and the LGLs has occurred while little change has occurred offshore. This highlights the necessity of monitoring both the littoral and pelagic zones of large lakes for assessing ecosystem health, change and conservation
Chromatin-associated regulation of sorbitol synthesis in flower buds of peach
[EN] Key message PpeS6PDH gene is postulated to mediate sorbitol synthesis in flower buds of peach concomitantly with specific chromatin modifications.
Abstract Perennial plants have evolved an adaptive mechanism involving protection of meristems within specialized structures named buds in order to survive low temperatures and water deprivation during winter. A seasonal period of dormancy further improves tolerance of buds to environmental stresses through specific mechanisms poorly known at the molecular level. We have shown that peach PpeS6PDH gene is down-regulated in flower buds after dormancy release, concomitantly with changes in the methylation level at specific lysine residues of histone H3 (H3K27 and H3K4) in the chromatin around the translation start site of the gene. PpeS6PDH encodes a NADPH-dependent sorbitol-6-phosphate dehydrogenase, the key enzyme for biosynthesis of sorbitol. Consistently, sorbitol accumulates in dormant buds showing higher PpeS6PDH expression. Moreover, PpeS6PDH gene expression is affected by cold and water deficit stress. Particularly, its expression is up-regulated by low temperature in buds and leaves, whereas desiccation treatment induces PpeS6PDH in buds and represses the gene in leaves. These data reveal the concurrent participation of chromatin modification mechanisms, transcriptional regulation of PpeS6PDH and sorbitol accumulation in flower buds of peach. In addition to its role as a major translocatable photosynthate in Rosaceae species, sorbitol is a widespread compatible solute and cryoprotectant, which suggests its participation in tolerance to environmental stresses in flower buds of peach.This work was funded by the Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA)-FEDER (RF2013-00043-C02-02) and the Ministry of Science and Innovation of Spain (AGL2010-20595). 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Identifying water stress-response mechanisms in citrus by in silico transcriptome analysis
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