OPTIMUM NOMINAL METHOD MODIFICATION AT THE MANAGEMENT OF MOVING OBJECTS UNDER UNCERTAINTY

ABSTRACT The articleis devoted to the development of models and information support for the search of the input parameters providing effective functioning of a moving object in the incompleteness data conditions. The problem of optimization is solved by theapplication of fuzzy intervals and variables. Parameters of moving objects of autonomous navigation and function of optimization are considered in the form of linguistic and fuzzy variables. Experts set functions of the accessory of fuzzy variables. The concept of the function of the accessory of deviations from the set face value of input parameter is defined. Modification of the method of the optimum of face value is considered at management of moving objects in the conditions of uncertainty. The algorithm and information support is developed for search of the fuzzy maximum of the function of the productivity of autonomous navigation at management of moving objects. The description of work with information support is provided

The requirement for Notch signaling at the -selection checkpoint in vivo is absolute and independent of the pre-T cell receptor

Genetic inactivation of Notch signaling in CD4−CD8− double-negative (DN) thymocytes was previously shown to impair T cell receptor (TCR) gene rearrangement and to cause a partial block in CD4+CD8+ double-positive (DP) thymocyte development in mice. In contrast, in vitro cultures suggested that Notch was absolutely required for the generation of DP thymocytes independent of pre-TCR expression and activity. To resolve the respective role of Notch and the pre-TCR, we inhibited Notch-mediated transcriptional activation in vivo with a green fluorescent protein–tagged dominant-negative Mastermind-like 1 (DNMAML) that allowed us to track single cells incapable of Notch signaling. DNMAML expression in DN cells led to decreased production of DP thymocytes but only to a modest decrease in intracellular TCRβ expression. DNMAML attenuated the pre-TCR–associated increase in cell size and CD27 expression. TCRα or TCRαβ transgenes failed to rescue DNMAML-related defects. Intrathymic injections of DNMAML− or DNMAML+ DN thymocytes revealed a complete DN/DP transition block, with production of DNMAML+ DP thymocytes only from cells undergoing late Notch inactivation. These findings indicate that the Notch requirement during the β-selection checkpoint in vivo is absolute and independent of the pre-TCR, and it depends on transcriptional activation by Notch via the CSL/RBP-J–MAML complex

Investigation of STEM subject and career aspirations of lower secondary school students in the North Calotte region of Finland, Norway, and Russia

Abstract This study investigates the suitability of the STEM Career Interest Survey (STEM-CIS) to measure secondary school students’ aspirations towards STEM subjects and careers. A confirmatory factor analysis (CFA) was conducted to assess the initial structural validity of the adapted STEM-CIS survey, where the science subscale was extended to four science disciplines, to align with the way science is taught in Finland and Russia. The results indicate that the interest in STEM subjects in general is not at a high level in any of the countries. There is a traditional gender gap regarding STEM subjects in every dimension, which favors females in biology and males in technology and engineering. STEM stereotypes among students—due to low exposure to STEM professions at school—can explain students’ low interest despite high self-efficacies. Our study shows that we must increase informal learning opportunities inside and outside school and improve career counselling for students so that they will be more informed of STEM career opportunities

The three-factor model:a study of common features in students’ attitudes towards studying and learning science and mathematics in the three countries of the North Calotte region

Abstract This study investigated common features of students’ attitudes towards studying science and mathematics in comprehensive and secondary schools in three countries. Data were obtained by conducting a survey (N = 581) in Norway, Finland and Russia. A Confirmatory factor analysis (CFA) provided a model with a three-factor solution consisting of factors: the perception of the teacher, anxiety towards science and mathematics, and motivation. The results suggest that most students are motivated to study sciences and mathematics. Data analysis indicate gender differences in attitudes to students’ future studies and career plans. Most girls recognized the importance of these subjects for their future studies and careers, while boys showed more interest than girls in local career opportunities in industry. Teachers have a significant role in directing students’ attitudes toward science and mathematics. Students experienced that the teachers who use innovative teaching approaches, both motivate and reduce anxiety, in their learning process

Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia

SummaryTribbles homolog 2 (Trib2) was identified as a downregulated transcript in leukemic cells undergoing growth arrest. To investigate the effects of Trib2 in hematopoietic progenitors, mice were reconstituted with hematopoietic stem cells retrovirally expressing Trib2. Trib2-transduced bone marrow cells exhibited a growth advantage ex vivo and readily established factor-dependent cell lines. In vivo, Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML). In mechanistic studies, we found that Trib2 associated with and inhibited C/EBPα. Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPα