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Examining the Relationships Among Categorization, Stereotype Activation, and Stereotype Application.
Increased category salience is associated with increased stereotyping. Prior research has not examined the processes that may account for this relationship. That is, it is unclear whether category salience leads to increased stereotyping by increasing stereotype activation (i.e., increased accessibility of stereotypic information), application (i.e., increasing the tendency to apply activated stereotypes), or both processes simultaneously. We examined this question across three studies by manipulating category salience in an implicit stereotyping measure and by applying a process model that provides independent estimates of stereotype activation and application. Our results replicated past findings that category salience increases stereotyping. Modeling results showed that category salience consistently increased the extent of stereotype application but increased stereotype activation in more limited contexts. Implications for models of social categorization and stereotyping are discussed
A MECHANISM TO CORRELATE DISTRIBUTED LOGS TO PERFORM ROOT CAUSE ANALYSIS AND SCOPE ASSESSMENT
For large distributed systems, it can be difficult to connect isolated types of data across multiple data logs, as well as to determine correlations among the data logs in order to perform root cause analysis during service outages such that a scope of damage can be assessed. Presented herein is a mechanism to correlate distributed data logs in order to perform root cause analysis and scope assessment. The mechanism may be utilized to analyze and resolve issues in large, complex distributed and/or cloud systems that generate high volumes of data logs
LONG SHORT TERM MEMORY BASED TOTAL TRAFFIC PREDICTION FOR CONTAINER LOAD BALANCING
Predictive load balancing is becoming increasingly relevant with the rapid adoption of machine learning models. Current load balancing approaches only considers the current state of the system, even though the current state of the system often varies. Accordingly, dispatch requests are provided herein which not only consider the current load on the system, but also the future load
USING EPBF TO SUPPORT DATA PLANE OBSERVABILITY WITH TRAFFIC MIRRORING
Techniques are presented herein that support a method for using the extended Berkeley Packet Filter (eBPF) to perform data plane traffic mirroring at an eXpress Data Path (XDP) level to provide data plane traffic observability. The presented techniques, which may be referred to herein as XeS, encompass an XeS agent component at a user level as well as an XeS server (i.e., an eBPF bytecode program) at a kernel level. The components may communicate through shared S-Map and F-Map tables. The presented techniques process Switch Port Analyzer (SPAN) source traffic efficiently at the XDP level immediately after packets arrive at the interface. Additionally, the presented techniques support Encapsulated Remote Switch Port Analyzer (ERSPAN) encapsulation and transmission to a destination through either a slow path (via the kernel Internet Protocol (IP) stack) or a fast path (directly at the XDP level using S-MAP entries installed by the XeS agent). For the fast path, the presented techniques support a new XDP-REPLICATE action code in addition to the existing XDP-REDIRECT or XDP-TX action codes
Hormander class of pseudo-differential operators on compact Lie groups and global hypoellipticity
In this paper we give several global characterisations of the Hormander class
of pseudo-differential operators on compact Lie groups. The result is applied
to give criteria for the ellipticity and the global hypoellipticity of
pseudo-differential operators in terms of their matrix-valued full symbols.
Several examples of the first and second order globally hypoelliptic
differential operators are given. Where the global hypoelliptiticy fails, one
can construct explicit examples based on the analysis of the global symbols.Comment: 20 page
Radium ion: A possible candidate for measuring atomic parity violation
Single trapped and laser cooled Radium ion as a possible candidate for
measuring the parity violation induced frequency shift has been discussed here.
Even though the technique to be used is similar to that proposed by Fortson
[1], Radium has its own advantages and disadvantages. The most attractive part
of Radium ion as compared to that of Barium ion is its mass which comes along
with added complexity of instability as well as other issues which are
discussed hereComment: Conference proceedin
Clinical evaluation of tuberculosis viability microscopy for assessing treatment response
Background.βIt is difficult to determine whether early tuberculosis treatment is effective in reducing the infectiousness of patients' sputum, because culture takes weeks and conventional acid-fast sputum microscopy and molecular tests cannot differentiate live from dead tuberculosis. Methods.βTo assess treatment response, sputum samples (n = 124) from unselected patients (n = 35) with sputum microscopyβpositive tuberculosis were tested pretreatment and after 3, 6, and 9 days of empiric first-line therapy. Tuberculosis quantitative viability microscopy with fluorescein diacetate, quantitative culture, and acid-fast auramine microscopy were all performed in triplicate. Results.βTuberculosis quantitative viability microscopy predicted quantitative culture results such that 76% of results agreed within Β±1 logarithm (r(S) = 0.85; P < .0001). In 31 patients with non-multidrug-resistant (MDR) tuberculosis, viability and quantitative culture results approximately halved (both 0.27 log reduction, P < .001) daily. For patients with non-MDR tuberculosis and available data, by treatment day 9 there was a >10-fold reduction in viability in 100% (24/24) of cases and quantitative culture in 95% (19/20) of cases. Four other patients subsequently found to have MDR tuberculosis had no significant changes in viability (P = .4) or quantitative culture (P = .6) results during early treatment. The change in viability and quantitative culture results during early treatment differed significantly between patients with non-MDR tuberculosis and those with MDR tuberculosis (both P < .001). Acid-fast microscopy results changed little during early treatment, and this change was similar for non-MDR tuberculosis vs MDR tuberculosis (P = .6). Conclusions.βTuberculosis quantitative viability microscopy is a simple test that within 1 hour predicted quantitative culture results that became available weeks later, rapidly indicating whether patients were responding to tuberculosis therapy
Local thermal adaptation and limited gene flow constrain future climate responses of a marine ecosystem engineer.
Rising ocean temperatures and extreme temperature events have precipitated declines and local extinctions in many marine species globally, but patterns of loss are often uneven across species ranges for reasons that are poorly understood. Knowledge of the extent of local adaptation and gene flow may explain such patterns and help predict future trajectories under scenarios of climate change. We test the extent to which local differentiation in thermal tolerance is influenced by gene flow and local adaptation using a widely distributed intertidal seaweed (Hormosira banksii) from temperate Australia. Population surveys across ~2,000Β km of the species range revealed strong genetic structuring at regional and local scales (global F STΒ =Β 0.243) reflecting extremely limited gene flow, while common garden experiments (14-day exposures to 15, 18, 21Β°C) revealed strong site differences in early development and mortality in response to elevated temperature. Embryos from many sites spanning a longitudinal thermal gradient showed suppressed development and increased mortality to elevated water temperatures, but populations originating from warmer and more variable thermal environments tended to be less susceptible to warming. Notably, there was significant local-scale variation in the thermal responses of embryos within regions which was corroborated by the finding of small-scale genetic differences. We expect the observed genetic and phenotypic differentiation to lead to uneven responses to warming sea surface temperatures in this important marine foundation species. The study highlights the challenges of predicting species responses to thermal stress and the importance of management strategies that incorporate evolutionary potential for "climate-proofing" marine ecosystems
Π£Π‘ΠΠΠ ΠΠΠΠ«Π Π‘ΠΠΠΠ ΠΠΠΠ ΠΠΠΠΠ¬ Π ΠΠΠΠΠΠ: ΠΠΠΠΠΠΠΠ«Π ΠΠΠΠΠΠΠ’ΠΠ ΠΠΠΠΠΠΠΠΠΠΠ ΠΠ Π£ΠΠΠΠΠ ΠΠΠΠΠΠ’Π Π―Π‘ΠΠΠΠ―
It is generally accepted that crustal earthquakes are caused by sudden displacement along faults, which rely on two primary conditions. One is that the fault has a high degree of synergism, so that once the stress threshold is reached, fault segments can be connected rapidly to facilitate fast slip of longer fault sections. The other is sufficient strain accumulated at some portions of the fault which can overcome resistance to slip of the high-strength portions of the fault. Investigations to such processes would help explore how to detect short-term and impending precursors prior to earthquakes. A simulation study on instability of a straight fault is conducted in the laboratory. From curves of stress variations, the stress state of the specimen is recognized and the meta-instability stage is identified. By comparison of the observational information from the press machine and physical parameters of the fields on the sample, this work reveals differences of temporal-spatial evolution processes of fault stress in the stages of stress deviating from linearity and meta-instability. The results show that due to interaction between distinct portions of the fault, their independent activities turn gradually into a synergetic activity, and the degree of such synergism is an indicator for the stress state of the fault. This synergetic process of fault activity includes three stages: generation, expansion and increase amount of strain release patches, and connection between them.. The first stage begins when the stress curve deviates from linearity, different strain variations occur at every portions of the fault, resulting in isolated areas of stress release and strain accumulation. The second stage is associated with quasi-static instability of the early meta-instability when isolated strain release areas of the fault increase and stable expansion proceeds. And the third stage corresponds to the late meta-instability, i.e. quasi-dynamic instability as both the expansion of strain release areas and rise of strain level of strain accumulation areas are accelerated. The synergism is accelerated when the quasi-static expansion transforms into quasi-dynamic expansion, with interaction between fault segments as its mechanism. The essence of such transformation is that the expansion mechanism has changed, i.e. expansion of isolated fault segments is replaced by linkage of the interacting segments when the fault enters the critical state of a potential earthquake. Based on the experimental results, coupled with data on the temporal-spatial evolution of earthquakes along the Laohushan-Maomaoshan fault, west of the Haiyuan fault zone in northwestern China, the synergism process of this fault before the 6 June 2000 M6.2 earthquake is analyzed.Β ΠΠ±ΡΡΠ½ΠΎ ΠΏΡΠΈΠ½ΡΡΠΎ ΡΡΠΈΡΠ°ΡΡ, ΡΡΠΎ ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ Π·Π΅ΠΌΠ»Π΅ΡΡΡΡΠ΅Π½ΠΈΠΉ Π·Π΅ΠΌΠ½ΠΎΠΉ ΠΊΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π½Π΅Π·Π°ΠΏΠ½ΠΎΠ΅ ΡΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ Π²Π΄ΠΎΠ»Ρ ΡΠ°Π·Π»ΠΎΠΌΠ° ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ Π΄Π²ΡΡ
ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΠΉ. ΠΠ΅ΡΠ²ΠΎΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΠ΅ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ Π²ΡΡΠΎΠΊΠΈΠΌ ΡΠΈΠ½Π΅ΡΠ³ΠΈΠ·ΠΌΠΎΠΌ ΡΠ°Π·Π»ΠΎΠΌΠ°, ΠΊΠΎΠ³Π΄Π° ΠΏΡΠΈ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΠΈ ΠΏΡΠ΅Π΄Π΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠ΅ ΡΡΠ°ΡΡΠΊΠΈ ΡΠ°Π·Π»ΠΎΠΌΠ° ΠΎΡΠ΅Π½Ρ Π±ΡΡΡΡΠΎ ΡΠΎΠ΅Π΄ΠΈΠ½ΡΡΡΡΡ Π΄ΡΡΠ³ Ρ Π΄ΡΡΠ³ΠΎΠΌ, ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡ Π±ΡΡΡΡΠΎΠΌΡ ΡΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π±ΠΎΠ»Π΅Π΅ Π΄Π»ΠΈΠ½Π½ΡΡ
ΡΡΠ°ΡΡΠΊΠΎΠ² Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ°Π·Π»ΠΎΠΌΠ°. ΠΡΠΎΡΠΎΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΠ΅ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΈ, Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠΌ Π½Π° ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
ΡΡΠ°ΡΡΠΊΠ°Ρ
ΡΠ°Π·Π»ΠΎΠΌΠ°, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΌ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΏΡΠ΅ΠΎΠ΄ΠΎΠ»Π΅Π½ΠΎ ΡΠΎΠΏΡΠΎΡΠΈΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π²ΡΡΠΎΠΊΠΎΠΏΡΠΎΡΠ½ΡΡ
ΡΡΠ°ΡΡΠΊΠΎΠ² ΡΠ°Π·Π»ΠΎΠΌΠ°. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ°ΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΌΠΎΠΆΠ΅Ρ ΠΏΠΎΠΌΠΎΡΡ Π² Π²ΡΡΠ²Π»Π΅Π½ΠΈΠΈ ΠΊΡΠ°ΡΠΊΠΎΡΡΠΎΡΠ½ΡΡ
Π½Π΅ΠΈΠ·Π±Π΅ΠΆΠ½ΡΡ
ΠΏΡΠ΅Π΄Π²Π΅ΡΡΠ½ΠΈΠΊΠΎΠ², ΠΏΡΠΎΡΠ²Π»ΡΡΡΠΈΡ
ΡΡ ΠΏΠ΅ΡΠ΅Π΄ Π·Π΅ΠΌΠ»Π΅ΡΡΡΡΠ΅Π½ΠΈΡΠΌΠΈ. Π Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΠΏΡΡΠΌΠΎΠ³ΠΎ ΡΠ°Π·Π»ΠΎΠΌΠ°. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΠΊΡΠΈΠ²ΡΠ΅ Π²Π°ΡΠΈΠ°ΡΠΈΠΉ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΈ Π²ΡΡΠ²ΠΈΡΡ ΡΡΠ°Π΄ΠΈΡ ΠΌΠ΅ΡΠ°Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ. Π Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ Π΄Π°Π½Π½ΡΡ
, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΏΡΡΠ΅ΠΌ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π½Π° ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΠΎΠΉ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ΅, Ρ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ°ΠΌΠΈ ΠΏΠΎΠ»Π΅ΠΉ ΠΎΠ±ΡΠ°Π·ΡΠ° ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ ΡΠ°Π·Π»ΠΈΡΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΠΎ-Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ°Π·Π»ΠΎΠΌΠ½ΡΡ
Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ ΠΏΠΎ ΡΡΠ°Π΄ΠΈΡΠΌ, ΠΊΠΎΠ³Π΄Π° ΠΎΡΠΌΠ΅ΡΠ΅Π½Ρ ΠΎΡΠΊΠ»ΠΎΠ½Π΅Π½ΠΈΡ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ ΠΎΡ Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΡΡΠΈ ΠΈ ΠΌΠ΅ΡΠ°Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
ΡΡΠ°ΡΡΠΊΠΎΠ² ΡΠ°Π·Π»ΠΎΠΌΠ° ΠΈΡ
Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎΡΡΠ΅ΠΏΠ΅Π½Π½ΠΎ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ΠΈΡ Π² ΡΠΈΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, ΠΈ ΡΠ°ΠΊΠΎΠΉ ΡΠΈΠ½Π΅ΡΠ³ΠΈΠ·ΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ ΡΠ°Π·Π»ΠΎΠΌΠ°. ΠΡΠΎΡΠ΅ΡΡ ΡΠΈΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°Π·Π»ΠΎΠΌΠ° ΠΏΡΠΎΡ
ΠΎΠ΄ΠΈΡ ΡΡΠΈ ΡΡΠ°Π΄ΠΈΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ: Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅ Π½Π΅Π±ΠΎΠ»ΡΡΠΈΡ
ΡΡΠ°ΡΡΠΊΠΎΠ², Π³Π΄Π΅ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π°ΡΡΡΡ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ, ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ ΠΈ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠ°Π·ΠΌΠ΅ΡΠΎΠ² ΡΠ°ΠΊΠΈΡ
ΡΡΠ°ΡΡΠΊΠΎΠ² Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ ΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ ΡΡΠ°ΡΡΠΊΠΎΠ², Π³Π΄Π΅ ΠΈΠ΄Π΅Ρ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ. ΠΠ΅ΡΠ²Π°Ρ ΡΡΠ°Π΄ΠΈΡ Π½Π°ΡΠΈΠ½Π°Π΅ΡΡΡ, ΠΊΠΎΠ³Π΄Π° ΠΊΡΠΈΠ²Π°Ρ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ ΠΎΡΠΊΠ»ΠΎΠ½ΡΠ΅ΡΡΡ ΠΎΡ Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΡΡΠΈ, ΠΏΡΠΈ ΡΡΠΎΠΌ Π½Π° ΠΊΠ°ΠΆΠ΄ΠΎΠΌ ΡΡΠ°ΡΡΠΊΠ΅ ΡΠ°Π·Π»ΠΎΠΌΠ° ΠΈΠΌΠ΅ΡΡ ΠΌΠ΅ΡΡΠΎ Π²Π°ΡΠΈΠ°ΡΠΈΠΈ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ, Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΡΠ΅Π³ΠΎ ΠΏΠΎΡΠ²Π»ΡΡΡΡΡ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠ΅ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΡΡΠ°ΡΡΠΊΠΈ, Π³Π΄Π΅ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΈ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ. ΠΡΠΎΡΠ°Ρ ΡΡΠ°Π΄ΠΈΡ ΡΠ²ΡΠ·Π°Π½Π° Ρ ΠΊΠ²Π°Π·ΠΈΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡΡ ΡΠ°Π½Π½Π΅ΠΉ ΠΌΠ΅ΡΠ°Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ, ΠΊΠΎΠ³Π΄Π° ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠ΅ ΡΡΠ°ΡΡΠΊΠΈ ΡΠ°Π·Π»ΠΎΠΌΠ°, Π³Π΄Π΅ ΠΈΠ΄Π΅Ρ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ, ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°ΡΡΡΡ Π² ΡΠ°Π·ΠΌΠ΅ΡΠ°Ρ
ΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°Π΅ΡΡΡ ΠΈΡ
ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΠ΅ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅. Π’ΡΠ΅ΡΡΡ ΡΡΠ°Π΄ΠΈΡ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΠ΅Ρ ΠΏΠΎΠ·Π΄Π½Π΅ΠΉ ΠΌΠ΅ΡΠ°Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ, Ρ.Π΅. ΠΊΠ²Π°Π·ΠΈΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΡΡΠΊΠΎΡΡΡΡΡΡ ΠΊΠ°ΠΊ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ ΡΡΠ°ΡΡΠΊΠΎΠ² Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ, ΡΠ°ΠΊ ΠΈ ΡΡΠΈΠ»Π΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ Π½Π° ΡΡΠ°ΡΡΠΊΠ°Ρ
Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΠΉ. Π‘ΠΈΠ½Π΅ΡΠ³ΠΈΠ·ΠΌ ΡΡΠΊΠΎΡΡΠ΅ΡΡΡ, ΠΊΠΎΠ³Π΄Π° ΠΊΠ²Π°Π·ΠΈΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ΡΡ Π² ΠΊΠ²Π°Π·ΠΈΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅, ΠΏΡΠΈ ΡΡΠΎΠΌ Π΄Π΅ΠΉΡΡΠ²ΡΠ΅Ρ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠ°ΡΡΠΊΠ°ΠΌΠΈ ΡΠ°Π·Π»ΠΎΠΌΠ°. Π‘ΡΡΡ ΡΠ°ΠΊΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΈΒ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ° ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΡ ΡΡΠ°ΡΡΠΊΠΎΠ² β ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΡΠ°ΡΡΠΊΠΎΠ² ΡΠ°Π·Π»ΠΎΠΌΠ° ΡΠΌΠ΅Π½ΡΠ΅ΡΡΡ Π½Π° ΡΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΠ°ΠΊΠΈΡ
ΡΡΠ°ΡΡΠΊΠΎΠ² ΠΏΡΠΈ ΠΈΡ
Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΈ, ΠΊΠΎΠ³Π΄Π° ΡΠ°Π·Π»ΠΎΠΌ Π²Ρ
ΠΎΠ΄ΠΈΡ Π² ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΡΡ ΡΡΠ°Π΄ΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π·Π΅ΠΌΠ»Π΅ΡΡΡΡΠ΅Π½ΠΈΡ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π°Π½Π½ΡΡ
, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ ΠΏΡΡΠ΅ΠΌ ΠΈ Π΄ΠΎΠΏΠΎΠ»Π½Π΅Π½Π½ΡΡ
ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ΅ΠΉ ΠΎ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΠΎ-Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ Π·Π΅ΠΌΠ»Π΅ΡΡΡΡΠ΅Π½ΠΈΠΉ Π²Π΄ΠΎΠ»Ρ ΡΠ°Π·Π»ΠΎΠΌΠ° ΠΠ°ΠΎΡ
ΡΡΠ°Π½-ΠΠ°ΠΎΠΌΠ°ΠΎΡΠ°Π½ Π² Π·Π°ΠΏΠ°Π΄Π½ΠΎΠΉ ΡΠ°ΡΡΠΈ ΡΠ°Π·Π»ΠΎΠΌΠ½ΠΎΠΉ Π·ΠΎΠ½Ρ Π₯Π°ΠΉΡΠ°Π½Ρ Π² Π‘Π΅Π²Π΅ΡΠΎ-ΠΠΎΡΡΠΎΡΠ½ΠΎΠΌ ΠΠΈΡΠ°Π΅, ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠΈΠ½Π΅ΡΠ³ΠΈΠ·ΠΌΠ° Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ°Π·Π»ΠΎΠΌΠ° ΠΏΠ΅ΡΠ΅Π΄ Π·Π΅ΠΌΠ»Π΅ΡΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΌΠ°Π³Π½ΠΈΡΡΠ΄ΠΎΠΉ 6.2, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΏΡΠΎΠΈΠ·ΠΎΡΠ»ΠΎ 6 ΠΈΡΠ½Ρ 2000 Π³.
Sputum microscopy with fluorescein diacetate predicts tuberculosis infectiousness
Background. Sputum from patients with tuberculosis contains subpopulations of metabolically active and inactive Mycobacterium tuberculosis with unknown implications for infectiousness. Methods. We assessed sputum microscopy with fluorescein diacetate (FDA, evaluating M. tuberculosis metabolic activity) for predicting infectiousness. Mycobacterium tuberculosis was quantified in pretreatment sputum of patients with pulmonary tuberculosis using FDA microscopy, culture, and acid-fast microscopy. These 35 patientsβ 209 household contacts were followed with prevalence surveys for tuberculosis disease for 6 years. Results. FDA microscopy was positive for a median of 119 (interquartile range [IQR], 47β386) bacteria/Β΅L sputum, which was 5.1% (IQR, 2.4%β11%) the concentration of acid-fast microscopyβpositive bacteria (2069 [IQR, 1358β3734] bacteria/ΞΌL). Tuberculosis was diagnosed during follow-up in 6.4% (13/209) of contacts. For patients with lower than median concentration of FDA microscopyβpositive M. tuberculosis, 10% of their contacts developed tuberculosis. This was significantly more than 2.7% of the contacts of patients with higher than median FDA microscopy results (crude hazard ratio [HR], 3.8; P = .03). This association maintained statistical significance after adjusting for disease severity, chemoprophylaxis, drug resistance, and social determinants (adjusted HR, 3.9; P = .02). Conclusions. Mycobacterium tuberculosis that was FDA microscopy negative was paradoxically associated with greater infectiousness. FDA microscopyβnegative bacteria in these pretreatment samples may be a nonstaining, slowly metabolizing phenotype better adapted to airborne transmission
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