Do the home field, global advantage, and liability of unfamiliarness hypotheses hold? empirical evidence from Malaysia

The study explores the home field, global advantage, and liability of unfamiliarness hypotheses in the Malaysian banking sector. The results indicate that Malaysian banks have exhibited productivity progress mainly attributed to technological progress. The authors find negative relationship between foreign and government ownership and bank productivity. Likewise, the publicly listed banks have been relatively less productive compared to private banks, thus rejecting the market discipline hypothesis. The empirical findings suggest that foreign banks from the North American countries to be the least productive banking group lending support to the home field advantage and the limited form of the global advantage hypotheses

Broadband radiative quantities for the EarthCARE mission: the ACM-COM and ACM-RT products

The EarthCARE satellite mission's objective is to retrieve profiles of aerosol and water cloud physical properties from measurements made by its cloud-profiling radar, backscattering lidar, and passive multi-spectral imager. These retrievals, together with other geophysical properties, are input into broadband (BB) radiative transfer (RT) models that predict radiances and fluxes commensurate with measurements made and inferred from EarthCARE's BB radiometer (BBR). The scientific goal is that modelled and “observed” BB top-of-atmosphere (TOA) fluxes differ, on average, by less than ±10 W m−2. When sound synergistic retrievals from the ACM-CAP process (ACM: ATLID – backscattering lidar, CPR – cloud-profiling radar, and MSI – multi-spectral imager; CAP: clouds, aerosols, and precipitation) are available, they are acted on by the RT models. When they are not available, the RT models act on “composite” profiles of properties retrieved from measurements made by individual sensors. Compositing is performed in the ACM-COM (COM: composite) process. The majority of this report describes the RT models – and their products – that make up EarthCARE's ACM-RT process. Profiles of BB shortwave (SW) and longwave (LW) fluxes and heating rates (HRs) are computed by 1D RT models for each ∼ 1 km nadir column of inferred properties. Three-dimensional RT models compute radiances for the BBR's three viewing directions, with the SW model also computing flux and HR profiles; the 3D LW model produces upwelling flux at just one level. All 3D RT products are averages over 5×21 km “assessment domains” that are constructed using MSI data. Some of ACM-RT's products are passed forward to the “radiative closure assessment” process that quantifies, for each assessment domain, the likelihood that EarthCARE's goal has been achieved. As EarthCARE represents the first mission to make “operational” use of 3D RT models, emphasis is placed on differences between 1D and 3D RT results. For upwelling SW flux at 20 km altitude, 1D and 3D values can be expected to differ by more than EarthCARE's scientific goal of ±10 W m−2 at least 50 % of the time.</p

Across-track extension of retrieved cloud and aerosol properties for the EarthCARE mission: the ACMB-3D product

The narrow cross section of cloud and aerosol properties retrieved by L2 algorithms that operate on data from EarthCARE's nadir-pointing sensors is broadened across-track by an algorithm that is described and demonstrated here. This scene construction algorithm (SCA) consists of four components. At its core is a radiance-matching procedure that works with measurements made by EarthCARE's Multi-Spectral Imager (MSI). In essence, an off-nadir pixel gets filled with retrieved profiles that are associated with a (nearby) nadir pixel whose MSI radiances best match those of the off-nadir pixel. The SCA constructs a 3D array of cloud and aerosol (and surface) properties for entire frames that measure ∼6000 km along-track by 150 km across-track (i.e., the MSI's full swath). Constructed domains out to ∼15 km across-track on both sides of nadir are used explicitly downstream as input for 3D radiative transfer models that predict top-of-atmosphere (TOA) broadband solar and thermal fluxes and radiances. These quantities are compared to commensurate measurements made by EarthCARE's Broadband Radiometer (BBR), thus facilitating a continuous closure assessment of the retrievals. Three 6000 km ×200 km frames of synthetic EarthCARE observations were used to demonstrate the SCA. The main conclusion is that errors in modelled TOA fluxes that stem from use of 3D domains produced by the SCA are expected to be less than ±5 W m−2 and rarely larger than ±10 W m−2. As such, the SCA, as purveyor of information needed to run 3D radiative transfer models, should help more than hinder the radiative closure assessment of EarthCARE's L2 retrievals.</p

Diagnoses after newly-recorded abdominal pain in primary care: observational cohort study

This is the final version. Available on open access from the Royal College of General Practitioners via the DOI in this recordBackground: Non-acute abdominal pain in primary care is diagnostically challenging. Aim: To quantify the 1-year cumulative incidence of 35 non-malignant diagnoses and 9 cancers in adults after newly-recorded abdominal pain in primary care. Design and setting: Observational cohort study of Clinical Practice Research Datalink records. Methods: Participants (n, %male) aged 40-59 (n=59,864, 50.0%), 60-69 (n=29,461, 49.2%) and ≥70 (n=36,468, 36.9%) had newly-recorded abdominal pain during 01/01/2009-31/12/2013. Age- and sex-stratified 1-year cumulative incidence (95% confidence interval) by diagnosis is reported. Results: Most (>70%) participants had no pre-specified diagnoses after newly-recorded abdominal pain. Non-malignant diagnoses were most common: upper gastrointestinal problems (gastro-oesophageal reflux disease, hiatus hernia, gastritis, oesophagitis, and gastric/duodenal ulcer) in men and urinary tract infection in women. The incidence of upper-gastrointestinal problems plateaued at ≥60 years [40-59: men 4.9% (4.6%–5.1%), women 4.0% (3.8%–4.2%); 60-69: men 5.8% (5.4%–6.2%), women 5.4% (5.1%–5.8%)]. Urinary tract infection incidence increased with age [40-59: women 5.1% (4.8%–5.3%), men 1.1% (1.0%–1.2%); ≥70: women 8.0% (7.6%–8.4%), men 3.3% (3.0%–3.6%)]. Diverticular disease incidence rose with age, plateauing at 4.2% (3.9%–4.6%) in men ≥60, increasing to 6.1% (5.8%–6.4%) in women ≥70. Irritable bowel syndrome incidence was higher in women (40-59: 3.0%, 2.8%–3.2%) than men (40-59: 2.1%, 2.0%–2.3%), decreasing with age to 1.3% (1.2%–1.5%) and 0.6% (0.5%–0.8%) at ≥70. Conclusion: We rank the incidence of diagnoses after newly-recorded abdominal pain by sex and age. While abdominal pain commonly remains unexplained, non-malignant diagnosis are more likely than cancer.UK Department of Health and Social CareNational Institute for Health Research (NIHR)Dennis and Mirelle Gillings FoundationCancer Research UKMacmilla

Intra-abdominal cancer risk with abdominal pain: a prospective cohort primary-care study

This is the author accepted manuscript. The final version is available from the Royal College of General Practitioners via the DOI in this record Background: Quantifying cancer risk in primary-care patients reporting abdominal pain would inform diagnostic strategies. Aim: To quantify oesophagogastric, colorectal, liver, pancreatic, ovarian, uterine, kidney and bladder cancer risks associated with newly reported abdominal pain with or without other symptoms, signs or abnormal blood tests (i.e. features) indicative of possible cancer. Design and setting: Observational prospective cohort study using Clinical Practice Research Datalink records with English cancer registry linkage. Methods: Participants (N=125,793) aged ≥40 years had newly reported abdominal pain in primary care during 01/01/2009-31/12/2013. The outcomes were 1-year cumulative incidence of cancer, and the composite 1-year cumulative incidence of cancers with shared additional features, stratified by age and sex. Results: With abdominal pain, overall risk was greater in men and increased with age, reaching 3.4% (95%CI 3.0–3.7%; predominantly colorectal cancer 1.9%, 1.6–2.1%) in men ≥70 years, compared with their expected incidence of 0.88% (0.87%–0.89%). Additional features increased cancer risk; for example, colorectal or pancreatic cancer risk with abdominal pain plus diarrhoea at 60–69 and ≥70, respectively, was 3.1% (1.9–4.9%) and 4.9% (3.7–6.4%), predominantly colorectal cancer (2.2%, 2–3.8% and 3.3%, 2.0–4.9%). Conclusions: Abdominal pain increases intra-abdominal cancer risk nearly fourfold in men aged ≥70, exceeding the 3% threshold warranting investigation. This threshold is surpassed for the over-60s only with additional features. These results help direct appropriate referral and testing strategies for patients based on their demographic profile and reporting features. We suggest non-invasive strategies first, such as faecal immunochemical testing, with safety-netting in a shared decision-making framework.National Institute for Health ResearchDepartment of Health and Social CareDennis and Mirelle Gillings Foundatio

Symptom lead times in lung and colorectal cancers: What are the benefits of symptom-based approaches to early diagnosis?

This is the final version of the article. Available from Cancer Research UK via the DOI in this record.Background: Individuals with undiagnosed lung and colorectal cancers present with non-specific symptoms in primary care more often than matched controls. Increased access to diagnostic services for patients with symptoms generates more early-stage diagnoses, but the mechanisms for this are only partially understood. Methods: We re-analysed a UK-based case-control study to estimate the Symptom Lead Time (SLT) distribution for a range of potential symptom criteria for investigation. Symptom Lead Time is the time between symptoms caused by cancer and eventual diagnosis, and is analogous to Lead Time in a screening programme. We also estimated the proportion of symptoms in lung and colorectal cancer cases that are actually caused by the cancer. Results: Mean Symptom Lead Times were between 4.1 and 6.0 months, with medians between 2.0 and 3.2 months. Symptom Lead Time did not depend on stage at diagnosis, nor which criteria for investigation are adopted. Depending on the criteria, an estimated 27-48% of symptoms in individuals with as yet undiagnosed lung cancer, and 12-32% with undiagnosed colorectal cancer are not caused by the cancer. Conclusions: In most cancer cases detected by a symptom-based programme, the symptoms are caused by cancer. These cases have a short lead time and benefit relatively little. However, in a significant minority of cases cancer detection is serendipitous. This group experiences the benefits of a standard screening programme, a substantial mean lead time and a higher probability of early-stage diagnosis.This work was supported by the National Institute for Health Research (NIHR) Programme Grants for Applied Research Programme, RP-PG-0608-10045

In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype

The aim of this study was to investigate HLA class II associations in polymyositis (PM) and dermatomyositis (DM), and to determine how these associations influence clinical and serological differences. DNA samples were obtained from 225 UK Caucasian idiopathic inflammatory myopathy patients (PM = 117, DM = 108) and compared with 537 randomly selected UK Caucasian controls. All cases had also been assessed for the presence of related malignancy and interstitial lung disease (ILD), and a number of myositis-specific/myositis-associated antibodies (MSAs/MAAs). Subjects were genotyped for HLA-DRB1, DQA1 and DQB1. HLA-DRB1*03, DQA1*05 and DQB1*02 were associated with an increased risk for both PM and DM. The HLA-DRB1*03-DQA1*05-DQB1*02 haplotype demonstrated strong association with ILD, irrespective of myositis subtype or presence of anti-aminoacyl-transfer RNA synthetase antibodies. The HLA-DRB1*07-DQA1*02-DQB1*02 haplotype was associated with risk for anti-Mi-2 antibodies, and discriminated PM from DM (odds ratio 0.3, 95% confidence interval 0.1–0.6), even in anti-Mi-2 negative patients. Other MSA/MAAs showed specific associations with other HLA class II haplotypes, irrespective of myositis subtype. There were no genotype, haplotype or serological associations with malignancy. The HLA-DRB1*03-DQA1*05-DQB1*02 haplotype associations appear to not only govern disease susceptibility in Caucasian PM/DM patients, but also phenotypic features common to PM/DM. Though strongly associated with anti-Mi-2 antibodies, the HLA-DRB1*07-DQA1*02-DQB1*02 haplotype shows differential associations with PM/DM disease susceptibility. In conclusion, these findings support the notion that myositis patients with differing myositis serology have different immunogenetic profiles, and that these profiles may define specific myositis subtypes

Observation of exotic meson production in the reaction π−p→η′π−p \pi^{-} p \to \eta^{\prime} \pi^- p at 18 GeV/c

An amplitude analysis of an exclusive sample of 5765 events from the reaction $\pi^{-} p \to \eta^{\prime} \pi^- p$ at 18 GeV/c is described. The $\eta^{\prime} \pi^-$ production is dominated by natural parity exchange and by three partial waves: those with $J^{PC} = 1^{-+}, 2^{++},$ and $4^{++}$. A mass-dependent analysis of the partial-wave amplitudes indicates the production of the $a_2(1320)$ meson as well as the $a_4(2040)$ meson, observed for the first time decaying to $\eta^{\prime}\pi^-$. The dominant, exotic (non-$q\bar{q})$ $1^{-+}$ partial wave is shown to be resonant with a mass of $1.597 \pm 0.010^{+0.045}_{-0.010}$ GeV/c^2 and a width of $0.340 \pm 0.040 \pm 0.050$ GeV/c^2 . This exotic state, the $\pi_1(1600)$, is produced with a $t$ dependence which is different from that of the $a_2(1320)$ meson, indicating differences between the production mechanisms for the two states.Comment: 5 pages with 4 figure

Water Vapor Measurements by Howard University Raman Lidar during the WAVES 2006 Campaign

Retrieval of water vapor mixing ratio using the Howard University Raman Lidar is presented with emphasis on three aspects: i) performance of the lidar against collocated radiosondes and Raman lidar, ii) investigation of the atmospheric state variables when poor agreement between lidar and radiosondes values occurred and iii) a comparison with satellite-based measurements. The measurements were acquired during the Water Vapor Validation Experiment Sondes/Satellites 2006 field campaign. Ensemble averaging of water vapor mixing ratio data from ten night-time comparisons with Vaisala RS92 radiosondes shows on average an agreement within 10 % up to approx. 8 km. A similar analysis of lidar-to-lidar data of over 700 profiles revealed an agreement to within 20 % over the first 7 km (10 % below 4 km). A grid analysis, defined in the temperature - relative humidity space, was developed to characterize the lidar - radiosonde agreement and quantitatively localizes regions of strong and weak correlations as a function of altitude, temperature or relative humidity. Three main regions of weak correlation emerge: i) regions of low relative humidity and low temperature, ii) moderate relative humidity at low temperatures and iii) low relative humidity at moderate temperatures. Comparison of Atmospheric InfraRed Sounder and Tropospheric Emission Sounder satellites retrievals of moisture with that of Howard University Raman Lidar showed a general agreement in the trend but the formers miss a lot of the details in atmospheric structure due to their low resolution. A relative difference of about 20 % is usually found between lidar and satellites measurements