Cтили совладающего поведения и смысложизненные ориентации китайских студентов в период адаптации к обучению в университете в России и на родине

The article describes the results of the research of coping styles and life meaning orientations of students from China, studying at Peoples' Friendship University of Russia and the He Bei United University of Tang Shan (China), in the process of overcoming the difficulties of adaptation to studying at University.В статье описываются результаты исследования стилей совладающего поведения и смысложизненных ориентаций студентов из Китая, обучающихся в РУДН и в Объединенном университете Хе Бей, г. Тан Шань (Китай), в процессе преодоления трудностей адаптации к обучению в вузе

Styles of Coping and Life Meaning Orientations of Chinese Students During the Period of Adaptation to Studying at University in Russia and in their Home Country

The article describes the results of the research of coping styles and life meaning orientations of students from China, studying at Peoples' Friendship University of Russia and the He Bei United University of Tang Shan (China), in the process of overcoming the difficulties of adaptation to studying at University

ZBP1 promotes hepatocyte pyroptosis in acute liver injury by regulating the PGAM5/ROS pathway

Introduction and Objectives: Acute liver injury (ALI) is characterized by massive hepatocyte death with high mortality and poor prognosis. Hepatocyte pyroptosis plays a key role in the physiopathological processes of ALI, which can damage mitochondria and release NLRP3 inflammasome particles, causing systemic inflammatory responses. Z-DNA Binding Protein 1 (ZBP1) is a sensor that induces cell death. Here, we investigated whether ZBP1 participates in hepatocyte pyroptosis and explored the possible pathogenesis of ALI. Materials and Methods: Hepatocyte pyrotosis was induced with lipopolysaccharide (LPS) and nigericin (Nig), and the expression of Zbp1 (ZBP1) was examined by western blot analysis and RT-qPCR. Further, we transfected AML-12 (LO2 and HepG2) cell lines with Zbp1 (ZBP1) siRNA. After ZBP1 was silenced, LDH release and flow cytometry were used to measure the cell death; Western blot analysis and RT-qPCR were used to detect the marker of NLRP3 inflammasome activation and pyroptosis. We also detected the expression of mitochondrial linear rupture marker phosphoglycerate mutase family member 5 (PGAM5) using western blot analysis and reactive oxygen species (ROS) using the DCFH-DA method. Results: The expression of ZBP1 was up-regulated in LPS/Nig-induced hepatocytes. Si-Zbp1 (Si-ZBP1) inhibited NLRP3 inflammasome activation and pyroptosis in LPS/Nig-induced hepatocytes. Moreover, ZBP1 silencing inhibited the expression of PGAM5 by reducing ROS production. Conclusions: ZBP1 promotes hepatocellular pyroptosis by modulating mitochondrial damage, which facilitates the extracellular release of ROS

The complete mitochondrial genome of the hybrid of Jersey cattle (Bos taurus; ♂) × Gannan yak (Bos grunniens; ♀)

In this study, we reconstructed the complete mitochondrial genome of the hybrid of Jersey cattle (Bos taurus; ♂) × Gannan yak (Bos grunniens; ♀) from Illumina sequencing reads. The mitochondrial genome is 16,322 bp in length with an A + T-biased nucleotide composition, and encodes 13 protein-coding genes, 22 tRNAs, and 2 rRNAs along with a noncoding control region. In addition, its gene order is identical to those of previously published mitochondrial genomes of the genera Bison and Bos. Phylogenetic analysis indicates that this hybrid is most closely related to Gannan yak and Jinchuan yak

Liver injury in COVID-19: clinical features and treatment management

Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread to many countries around the world. In addition to lung disease, severe cases also displayed varying degrees of liver injury. This article will describe the latest developments regarding coronavirus and the pathogenesis of liver injury, the prone population and clinical characteristics of these patients, as well as providing some suggestions for clinical treatment