Nondestructive testing of marine protective coatings using terahertz waves with stationary wavelet transform

Terahertz wave propagation in marine protective coatings and its non-destructive testing (NDT) capability were studied by the finite difference time domain (FDTD) method. The FDTD model was used to calculate the propagation and reflection of THz radiation from marine protective coatings. The reflected terahertz waves could be employed in coating thickness analysis of the paint layers. In order to clearly identify the interface between antifouling and anticorrosive coatings, stationary wavelet transform (SWT) approach was applied to decompose the obtained terahertz impulse functions into approximation and detail coefficients; SWT detail coefficients were used for the feature extraction of the coating thickness. SWT provides a more accurate identification of salient features in a signal, such as the weak feature between antifouling and anticorrosive coatings. We found that the developed model and SWT-based algorithms could be used to evaluate the occurrence of defects beneath the coatings (e.g., paint-off and corrosion defects). The proposed method provides the solution for coating thickness of marine protective coatings and it would benefit the effective maintenance to avoid coating failure and facilitate marine protective coating design. Therefore, non-destructive testing and evaluation of marine protective coating system by terahertz waves with SWT could be recommended for engineering applications

Quantifying Pharmaceutical Film Coating with Optical Coherence Tomography and Terahertz Pulsed Imaging: An Evaluation.

Spectral domain optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for quantification of thin film coatings that cannot easily be resolved with other techniques. Because of the relative infancy of this technique, much of the research to date has focused on developing the in-line measurement technique for assessing film coating thickness. To better assess OCT for pharmaceutical coating quantification, this paper evaluates tablets with a range of film coating thickness measured using OCT and terahertz pulsed imaging (TPI) in an off-line setting. In order to facilitate automated coating quantification for film coating thickness in the range of 30-200 μm, an algorithm that uses wavelet denoising and a tailored peak finding method is proposed to analyse each of the acquired A-scan. Results obtained from running the algorithm reveal an increasing disparity between the TPI and OCT measured intra-tablet variability when film coating thickness exceeds 100 μm. The finding further confirms that OCT is a suitable modality for characterising pharmaceutical dosage forms with thin film coatings, whereas TPI is well suited for thick coatings.The authors would like to acknowledge the financial support from UK EPSRC Research Grant EP/L019787/1 and EP/L019922/1.This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/jps.2453

From Terahertz Imaging to Terahertz Wireless Communications

Terahertz (THz) technology is probably best known to the public as a powerful tool for imaging, since it has been applied in security and medical scanning, resulting in numerous impressive images that would be unobtainable using other technologies. With the roll-out of 5G mobile networks, research into 6G wireless communications is heating up. It is envisioned that THz technology will be used for 6G and future wireless communications. In this paper, we review how THz technology has been employed for imaging and wireless communications, identify state-of-the-art developments in the field, and then examine and compare common devices and issues in both applications. The possibility of integrating THz imaging/sensing and wireless communications is considered, and challenges and future perspectives are presented and discussed. It is shown that THz technology is indeed a key enabling technology for both imaging and wireless communications in the future

Broadband terahertz time-domain spectroscopy and fast FMCW imaging: principle and applications

We report a broadband terahertz time-domain spectroscopy (THz-TDS) which enables twenty vibrational modes of adenosine nucleoside to be resolved in a wide frequency range of 1–20 THz. The observed spectroscopic features of adenosine are in good agreement with the published spectra obtained using Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. This much extended bandwidth leads to enhanced material characterization capability as it provides spectroscopic information on both intra- and inter-molecular vibrations. In addition, we also report a low-cost frequency modulation continuous wave (FMCW) imaging system which has a fast measurement speed of 40000 waveforms per second. Cross-sectional imaging capability through cardboard has also been demonstrated using its excellent penetration capability at a frequency range of 76–81 GHz. We anticipate that the integration of these two complementary imaging technologies would be highly desirable for many real-world applications because it provides both spectroscopic discrimination and penetration capabilities in a single instrument

Optical Trapping and Separation of Metal Nanoparticles by Cylindrical Metalenses With Phase Gradients

We proposed a method for driving metal nanoparticles in the focal field by cylindrical metalens with phase gradient. It was found that the introduced gradient phase would not affect the formation of the focal line, where metal nanoparticles can be trapped. While being driven along the direction with the phase gradient, Ag nanoparticles with different sizes, and nanoparticles with different materials (Au and Ag) were successfully separated, respectively. The induced driving force has an approximately linear relationship with the phase gradient. This kind of planar thin structure can be combined with a microfluidic chip to form a miniaturized system for label-free and non-contact sorting of particles or biological cells, and it may find potential applications in biomedicine

Measurement of the Intertablet Coating Uniformity of a Pharmaceutical Pan Coating Process With Combined Terahertz and Optical Coherence Tomography In-Line Sensing.

We present in-line coating thickness measurements acquired simultaneously using two independent sensing modalities: terahertz pulsed imaging (TPI) and optical coherence tomography (OCT). Both techniques are sufficiently fast to resolve the coating thickness of individual pharmaceutical tablets in-situ during the film coating operation and both techniques are direct structural imaging techniques that do not require multivariate calibration. The TPI sensor is suitable to measure coatings greater than 50 μm and can penetrate through thick coatings even in the presence of pigments over a wide range of excipients. Due to the long wavelength, terahertz radiation is not affected by scattering from dust within the coater. In contrast, OCT can resolve coating layers as thin as 20 μm and is capable of measuring the intra-tablet coating uniformity as well as the inter-tablet coating thickness distribution within the coating pan. ¬-However, the OCT technique is less robust when it comes to the compatibility with excipients, dust and potentially the maximum coating thickness that can be resolved. Using a custom built laboratory scale coating unit, the coating thickness measurements were acquired independently by the TPI and OCT sensors throughout a film coating operation. Results of the in-line TPI and OCT measurements were compared against one another and validated with off-line TPI and weight gain measurements. Compared to other process analytical technology (PAT) sensors, such as near-infrared and Raman spectroscopy, the TPI/OCT sensors can resolve the inter-tablet thickness distribution based on sampling a significant fraction of the tablet populations in the process. By combining two complementary sensing modalities it was possible to seamlessly monitor the coating process over the range of film thickness from 20 μm to greater than 250 μm.The authors would like to acknowledge the financial support from UK EPSRC Research Grant EP/L019787/1 and EP/L019922/1. The authors acknowledge BASF for providing the materials used in this study, Colorcon Ltd. (Dartford, UK) for coating process recommendations, Hüttlin GmbH (Bosch Packaging Technology, Schopfheim, Germany) for advice on the coating unit design and the staff of the electronics and mechanical workshops in Department of Chemical Engineering and Biotechnology at University of Cambridge. HL also acknowledges travel support from Joy Welch Educational Charitable Trust

Measurement of the Intertablet Coating Uniformity of a Pharmaceutical Pan Coating Process With Combined Terahertz and Optical Coherence Tomography In-Line Sensing.

We present in-line coating thickness measurements acquired simultaneously using 2 independent sensing modalities: terahertz pulsed imaging (TPI) and optical coherence tomography (OCT). Both techniques are sufficiently fast to resolve the coating thickness of individual pharmaceutical tablets in situ during the film coating operation, and both techniques are direct structural imaging techniques that do not require multivariate calibration. The TPI sensor is suitable to measure coatings greater than 50 μm and can penetrate through thick coatings even in the presence of pigments over a wide range of excipients. Due to the long wavelength, terahertz radiation is not affected by scattering from dust within the coater. In contrast, OCT can resolve coating layers as thin as 20 μm and is capable of measuring the intratablet coating uniformity and the intertablet coating thickness distribution within the coating pan. However, the OCT technique is less robust when it comes to the compatibility with excipients, dust, and potentially the maximum coating thickness that can be resolved. Using a custom-built laboratory scale coating unit, the coating thickness measurements were acquired independently by the TPI and OCT sensors throughout a film coating operation. Results of the in-line TPI and OCT measurements were compared against one another and validated with off-line TPI and weight gain measurements. Compared with other process analytical technology sensors, such as near-infrared and Raman spectroscopy, the TPI and OCT sensors can resolve the intertablet thickness distribution based on sampling a significant fraction of the tablet populations in the process. By combining 2 complementary sensing modalities, it was possible to seamlessly monitor the coating process over the range of film thickness from 20 μm to greater than 250 μm.The authors would like to acknowledge the financial support from UK EPSRC Research Grant EP/L019787/1 and EP/L019922/1. The authors acknowledge BASF for providing the materials used in this study, Colorcon Ltd. (Dartford, UK) for coating process recommendations, Hüttlin GmbH (Bosch Packaging Technology, Schopfheim, Germany) for advice on the coating unit design and the staff of the electronics and mechanical workshops in Department of Chemical Engineering and Biotechnology at University of Cambridge. HL also acknowledges travel support from Joy Welch Educational Charitable Trust