143 research outputs found
Radiographic evaluation of posterior selective thoracolumbar or lumbar fusion for moderate Lenke 5C curves
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Electroplating lithium transition metal oxides.
Materials synthesis often provides opportunities for innovation. We demonstrate a general low-temperature (260°C) molten salt electrodeposition approach to directly electroplate the important lithium-ion (Li-ion) battery cathode materials LiCoO2, LiMn2O4, and Al-doped LiCoO2. The crystallinities and electrochemical capacities of the electroplated oxides are comparable to those of the powders synthesized at much higher temperatures (700° to 1000°C). This new growth method significantly broadens the scope of battery form factors and functionalities, enabling a variety of highly desirable battery properties, including high energy, high power, and unprecedented electrode flexibility
Spatiotemporal genomic analysis reveals distinct molecular features in recurrent stage I non-small cell lung cancers
Stage I non-small cell lung cancer (NSCLC) presents diverse outcomes. To identify molecular features leading to tumor recurrence in early-stage NSCLC, we perform multiregional whole-exome sequencing (WES), RNA sequencing, and plasma-targeted circulating tumor DNA (ctDNA) detection analysis between recurrent and recurrent-free stage I NSCLC patients (CHN-P cohort) who had undergone R0 resection with a median 5-year follow-up time. Integrated analysis indicates that the multidimensional clinical and genomic model can stratify the prognosis of stage I NSCLC in both CHN-P and EUR-T cohorts and correlates with positive pre-surgical deep next generation sequencing (NGS) ctDNA detection. Increased genomic instability related to DNA interstrand crosslinks and double-strand break repair processes is significantly associated with early tumor relapse. This study reveals important molecular insights into stage I NSCLC and may inform clinical postoperative treatment and follow-up strategies
La violencia contra las personas sexo-género diverso su tratamiento en el sistema jurídico venezolano
The motivated violence against the diverse sex-gender people constitutes today a violation of the third generation human rights such as sexual rights. The purpose of the research is to make a reflexive analysis about the treatment that the Venezuelan legal system through its institutions, provides to the group of people that make up the Lesbian, Gay, Bisexual, Trans and Intersex community (LGBTI), taking as main documents the existing legislation in Venezuelan legislation as the Constitution (National Assembly. 1999), Organic Law on the Right of Women to a Life Free of Violence (National Assembly, 2007), Draft Organic Law on Equality and Gender Equality (National Assembly, 2010), Penal Code of Venezuela (National Assembly, 2005), Code of Forensic Medical Instruction (Congress of the United States of Venezuela, 1878), focusing it from the legal point of view and also trying to establish reasonable guidelines s ethical-moral, that guide the attitude of society in general. Gender violence can be a type of physical or psychological violence against any person based on their sex or gender that negatively impacts their identity and social, physical or psychological well-being, as in the case of sex-gender people diverse (LGBTI). The analytical-synthetic method was implemented to carry out the research through a bibliographic documentary review. It is concluded that sexual rights are universal human rights based on inherent freedom, dignity and equality for all human beings. Likewise, it can be seen that throughout the world there are people who face a high level of violence and discrimination because of their sexual orientation and gender identity and our country does not escape this reality.La violencia motivada contra las personas género-sexo diverso, constituye hoy en día a una violación a los derechos humanos de tercera generación como lo son los derechos sexuales. El propósito de la investigación es hacer un análisis reflexivo sobre el tratamiento que el ordenamiento jurídico venezolano a través de sus instituciones, le brinda al grupo de personas que integran la comunidad de Lesbianas, Gays, Bisexuales, Trans e intersex (LGBTI), tomando como principales documentos la normativa existente en la legislación venezolana promulgadas por la Constitución (Asamblea Nacional, 1999), Ley Orgánica sobre el Derecho de las Mujeres a una Vida Libre de Violencia (Asamblea Nacional, 2007), Anteproyecto de LeyOrgánica de Equidad e Igualdad de Género (Asamblea Nacional, 2010), Código Penal de Venezuela (Asamblea Nacional, 2005), Código de Instrucción Médico Forense (Congreso de los Estados Unidos de Venezuela, 1878), Código de Deontología Médica(Federación Médica Venezolana, 2003),enfocándolo desde el punto de vista jurídico legal y así mismo intentado establecer las directrices razonables éticas-morales, que orienten la actitud de la sociedad en general. La violencia de género puede ser un tipo de violencia física o psicológica ejercida contra cualquier persona sobre la base de su sexo o género que impacta de manera negativa su identidad y bienestar social, físico o psicológico, como en el caso de las personas sexo-género diversos (LGBTI). Fue implementado el método analítico-sintético para la realización de la investigación por medio de una revisión documental bibliográfica. Se concluye que los derechos sexuales son derechos humanos universales basados en la libertad inherente, dignidad e igualdad para todos los seres humanos. Así mismo se puede constatar que en todo el mundo hay personas que se enfrentana un elevado nivel de violencia y discriminación por su orientación sexual y suidentidad de género y nuestro país no escapa de esta realidad
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Compressed glassy carbon: An ultrastrong and elastic interpenetrating graphene network
Carbon’s unique ability to have both sp2 and sp3 bonding states gives rise to a range of physical attributes, including excellent mechanical and electrical properties. We show that a series of lightweight, ultrastrong, hard, elastic, and conductive carbons are recovered after compressing sp2-hybridized glassy carbon at various temperatures. Compression induces the local buckling of graphene sheets through sp3 nodes to form interpenetrating graphene networks with long-range disorder and short-range order on the nanometer scale. The compressed glassy carbons have extraordinary specific compressive strengths—more than two times that of commonly used ceramics—and simultaneously exhibit robust elastic recovery in response to local deformations. This type of carbon is an optimal ultralight, ultrastrong material for a wide range of multifunctional applications, and the synthesis methodology demonstrates potential to access entirely new metastable materials with exceptional properties
Room temperature all-solid-state lithium batteries based on a soluble organic cage ionic conductor
All solid-state lithium batteries (SSLBs) are poised to have higher energy density and better safety than current liquid-based Li-ion batteries, but a central requirement is effective ionic conduction pathways throughout the entire cell. Here we develop a catholyte based on an emerging class of porous materials, porous organic cages (POCs). A key feature of these Li(+) conducting POCs is their solution-processibility. They can be dissolved in a cathode slurry, which allows the fabrication of solid-state cathodes using the conventional slurry coating method. These Li(+) conducting cages recrystallize and grow on the surface of the cathode particles during the coating process and are therefore dispersed uniformly in the slurry-coated cathodes to form a highly effective ion-conducting network. This catholyte is shown to be compatible with cathode active materials such as LiFePO(4), LiCoO(2) and LiNi(0.5)Co(0.2)Mn(0.3)O(2), and results in SSLBs with decent electrochemical performance at room temperature
EHD1 confers resistance to cisplatin in non-small cell lung cancer by regulating intracellular cisplatin concentrations
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