753 research outputs found
Lattices of hydrodynamically interacting flapping swimmers
Fish schools and bird flocks exhibit complex collective dynamics whose
self-organization principles are largely unknown. The influence of
hydrodynamics on such collectives has been relatively unexplored theoretically,
in part due to the difficulty in modeling the temporally long-lived
hydrodynamic interactions between many dynamic bodies. We address this through
a novel discrete-time dynamical system (iterated map) that describes the
hydrodynamic interactions between flapping swimmers arranged in one- and
two-dimensional lattice formations. Our 1D results exhibit good agreement with
previously published experimental data, in particular predicting the
bistability of schooling states and new instabilities that can be probed in
experimental settings. For 2D lattices, we determine the formations for which
swimmers optimally benefit from hydrodynamic interactions. We thus obtain the
following hierarchy: while a side-by-side single-row "phalanx" formation offers
a small improvement over a solitary swimmer, 1D in-line and 2D rectangular
lattice formations exhibit substantial improvements, with the 2D diamond
lattice offering the largest hydrodynamic benefit. Generally, our
self-consistent modeling framework may be broadly applicable to active systems
in which the collective dynamics is primarily driven by a fluid-mediated
memory
Following Black Hole Scaling Relations Through Gas-Rich Mergers
We present black hole mass measurements from kinematic modeling of
high-spatial resolution integral field spectroscopy of the inner regions of 9
nearby (ultra-)luminous infrared galaxies in a variety of merger stages. These
observations were taken with OSIRIS and laser guide star adaptive optics on the
Keck I and Keck II telescopes, and reveal gas and stellar kinematics inside the
spheres of influence of these supermassive black holes. We find that this
sample of black holes are overmassive ( M) compared to
the expected values based on black hole scaling relations, and suggest that the
major epoch of black hole growth occurs in early stages of a merger, as opposed
to during a final episode of quasar-mode feedback. The black hole masses
presented are the dynamical masses enclosed in 25pc, and could include
gas which is gravitationally bound to the black hole but has not yet lost
sufficient angular momentum to be accreted. If present, this gas could in
principle eventually fuel AGN feedback or be itself blown out from the system.Comment: accepted to Ap
Following black hole scaling relations through gas-rich mergers
We present black hole mass measurements from kinematic modeling of high-spatial resolution integral field spectroscopy of the inner regions of nine nearby (ultra-)luminous infrared galaxies in a variety of merger stages. These observations were taken with OSIRIS and laser guide star adaptive optics on the Keck I and Keck II telescopes, and reveal gas and stellar kinematics inside the spheres of influence of these supermassive black holes. We find that this sample of black holes are overmassive (~107–9 ) compared to the expected values based on black hole scaling relations, and suggest that the major epoch of black hole growth occurs in early stages of a merger, as opposed to during a final episode of quasar-mode feedback. The black hole masses presented are the dynamical masses enclosed in ~25 pc, and could include gas which is gravitationally bound to the black hole but has not yet lost sufficient angular momentum to be accreted. If present, this gas could in principle eventually fuel active galactic nucleus feedback or be itself blown out from the system
NOGO-A induction and localization during chick brain development indicate a role disparate from neurite outgrowth inhibition
BACKGROUND: Nogo-A, a myelin-associated protein, inhibits neurite outgrowth and abates regeneration in the adult vertebrate central nervous system (CNS) and may play a role in maintaining neural pathways once established. However, the presence of Nogo-A during early CNS development is counterintuitive and hints at an additional role for Nogo-A beyond neurite inhibition. RESULTS: We isolated chicken NOGO-A and determined its sequence. A multiple alignment of the amino acid sequence across divergent species, identified five previously undescribed, Nogo-A specific conserved regions that may be relevant for development. NOGO gene transcripts (NOGO-A, NOGO-B and NOGO-C) were differentially expressed in the CNS during development and a second NOGO-A splice variant was identified. We further localized NOGO-A expression during key phases of CNS development by in situ hybridization. CNS-associated NOGO-A was induced coincident with neural plate formation and up-regulated by FGF in the transformation of non-neural ectoderm into neural precursors. NOGO-A expression was diffuse in the neuroectoderm during the early proliferative phase of development, and migration, but localized to large projection neurons of the optic tectum and tectal-associated nuclei during architectural differentiation, lamination and network establishment. CONCLUSION: These data suggest Nogo-A plays a functional role in the determination of neural identity and/or differentiation and also appears to play a later role in the networking of large projection neurons during neurite formation and synaptogenesis. These data indicate that Nogo-A is a multifunctional protein with additional roles during CNS development that are disparate from its later role of neurite outgrowth inhibition in the adult CNS
Nature of complex singularities for the 2D Euler equation
A detailed study of complex-space singularities of the two-dimensional
incompressible Euler equation is performed in the short-time asymptotic
r\'egime when such singularities are very far from the real domain; this allows
an exact recursive determination of arbitrarily many spatial Fourier
coefficients. Using high-precision arithmetic we find that the Fourier
coefficients of the stream function are given over more than two decades of
wavenumbers by \hat F(\k) = C(\theta) k^{-\alpha} \ue ^ {-k \delta(\theta)},
where \k = k(\cos \theta, \sin \theta). The prefactor exponent ,
typically between 5/2 and 8/3, is determined with an accuracy better than 0.01.
It depends on the initial condition but not on . The vorticity diverges
as , where and is the distance to the
(complex) singular manifold. This new type of non-universal singularity is
permitted by the strong reduction of nonlinearity (depletion) which is
associated to incompressibility. Spectral calculations show that the scaling
reported above persists well beyond the time of validity of the short-time
asymptotics. A simple model in which the vorticity is treated as a passive
scalar is shown analytically to have universal singularities with exponent
.Comment: 22 pages, 24 figures, published version; a version of the paper with
higher-quality figures is available at http://www.obs-nice.fr/etc7/euler.pd
Analytic solutions and Singularity formation for the Peakon b--Family equations
Using the Abstract Cauchy-Kowalewski Theorem we prove that the -family
equation admits, locally in time, a unique analytic solution. Moreover, if the
initial data is real analytic and it belongs to with , and the
momentum density does not change sign, we prove that the
solution stays analytic globally in time, for . Using pseudospectral
numerical methods, we study, also, the singularity formation for the -family
equations with the singularity tracking method. This method allows us to follow
the process of the singularity formation in the complex plane as the
singularity approaches the real axis, estimating the rate of decay of the
Fourier spectrum
Yukawa potentials in systems with partial periodic boundary conditions I : Ewald sums for quasi-two dimensional systems
Yukawa potentials are often used as effective potentials for systems as
colloids, plasmas, etc. When the Debye screening length is large, the Yukawa
potential tends to the non-screened Coulomb potential ; in this small screening
limit, or Coulomb limit, the potential is long ranged. As it is well known in
computer simulation, a simple truncation of the long ranged potential and the
minimum image convention are insufficient to obtain accurate numerical data on
systems. The Ewald method for bulk systems, i.e. with periodic boundary
conditions in all three directions of the space, has already been derived for
Yukawa potential [cf. Y., Rosenfeld, {\it Mol. Phys.}, \bm{88}, 1357, (1996)
and G., Salin and J.-M., Caillol, {\it J. Chem. Phys.}, \bm{113}, 10459,
(2000)], but for systems with partial periodic boundary conditions, the Ewald
sums have only recently been obtained [M., Mazars, {\it J. Chem. Phys.}, {\bf
126}, 056101 (2007)]. In this paper, we provide a closed derivation of the
Ewald sums for Yukawa potentials in systems with periodic boundary conditions
in only two directions and for any value of the Debye length. A special
attention is paid to the Coulomb limit and its relation with the
electroneutrality of systems.Comment: 40 pages, 5 figures and 4 table
Crystal structures and freezing of dipolar fluids
We investigate the crystal structure of classical systems of spherical
particles with an embedded point dipole at T=0. The ferroelectric ground state
energy is calculated using generalizations of the Ewald summation technique.
Due to the reduced symmetry compared to the nonpolar case the crystals are
never strictly cubic. For the Stockmayer (i.e., Lennard-Jones plus dipolar)
interaction three phases are found upon increasing the dipole moment:
hexagonal, body-centered orthorhombic, and body-centered tetragonal. An even
richer phase diagram arises for dipolar soft spheres with a purely repulsive
inverse power law potential . A crossover between qualitatively
different sequences of phases occurs near the exponent . The results are
applicable to electro- and magnetorheological fluids. In addition to the exact
ground state analysis we study freezing of the Stockmayer fluid by
density-functional theory.Comment: submitted to Phys. Rev.
Controls on Dissolved Cobalt in Surface Waters of the Sargasso Sea: Comparisons with Iron and Aluminum
Dissolved cobalt (dCo), iron (dFe) and aluminum (dAl) were determined in water column samples along a meridional transect (∼31°N to 24°N) south of Bermuda in June 2008. A general north-to-south increase in surface concentrations of dFe (0.3-1.6 nM) and dAl (14-42 nM) was observed, suggesting that aerosol deposition is a significant source of dFe and dAl, whereas no clear trend was observed. for near-surface dCo concentrations. Shipboard aerosol samples indicate fractional solubility values of 8-100% for aerosol Co, which are significantly higher than corresponding estimates of the solubility of aerosol Fe (0.44-45%). Hydrographic observations and analysis of time series rain samples from Bermuda indicate that wet deposition accounts for most (\u3e80%) of the total aeolian flux of Co, and hence a significant proportion of the atmospheric input of dCo to our study region. Our aerosol data imply that the atmospheric input of dCo to the Sargasso Sea is modest, although this flux may be more significant in late summer. The water column dCo profiles reveal a vertical distribution that predominantly reflects nutrient-type behavior, vs. scavenged-type behavior for dAl, and a hybrid of nutrient- and scavenged-type behavior for dFe. Mesoscale eddies also appear to impact on the vertical distribution of dCo. The effects of biological removal of dCo from the upper water column were apparent as pronounced sub-surface min. (21 ± 4 pM dCo), coincident with maxima in Prochlorococcus abundance. These observations imply that Prochlorococcus plays a major role in removing dCo from the euphotic zone, and that the availability of dCo may regulate Prochlorococcus growth in the Sargasso Sea
Benefits of Incentives for Breastfeeding and Smoking cessation in pregnancy (BIBS): a mixed-methods study to inform trial design
Background: Smoking in pregnancy and/or not breastfeeding have considerable negative health outcomes for mother and baby. Aim: To understand incentive mechanisms of action for smoking cessation in pregnancy and breastfeeding, develop a taxonomy and identify promising, acceptable and feasible interventions to inform trial design. Design: Evidence syntheses, primary qualitative survey, and discrete choice experiment (DCE) research using multidisciplinary, mixed methods. Two mother-and-baby groups in disadvantaged areas collaborated throughout. Setting: UK. Participants: The qualitative study included 88 pregnant women/recent mothers/partners, 53 service providers, 24 experts/decision-makers and 63 conference attendees. The surveys included 1144 members of the general public and 497 health professionals. The DCE study included 320 women with a history of smoking. Methods: (1) Evidence syntheses: incentive effectiveness (including meta-analysis and effect size estimates), delivery processes, barriers to and facilitators of smoking cessation in pregnancy and/or breastfeeding, scoping review of incentives for lifestyle behaviours; (2) qualitative research: grounded theory to understand incentive mechanisms of action and a framework approach for trial design; (3) survey: multivariable ordered logit models; (4) DCE: conditional logit regression and the log-likelihood ratio test. Results: Out of 1469 smoking cessation and 5408 breastfeeding multicomponent studies identified, 23 smoking cessation and 19 breastfeeding studies were included in the review. Vouchers contingent on biochemically proven smoking cessation in pregnancy were effective, with a relative risk of 2.58 (95% confidence interval 1.63 to 4.07) compared with non-contingent incentives for participation (four studies, 344 participants). Effects continued until 3 months post partum. Inconclusive effects were found for breastfeeding incentives compared with no/smaller incentives (13 studies) but provider commitment contracts for breastfeeding show promise. Intervention intensity is a possible confounder. The acceptability of seven promising incentives was mixed. Women (for vouchers) and those with a lower level of education (except for breastfeeding incentives) were more likely to disagree. Those aged ≤ 44 years and ethnic minority groups were more likely to agree. Agreement was greatest for a free breast pump and least for vouchers for breastfeeding. Universal incentives were preferred to those targeting low-income women. Initial daily text/telephone support, a quitting pal, vouchers for > £20.00 per month and values up to £80.00 increase the likelihood of smoking cessation. Doctors disagreed with provider incentives. A ‘ladder’ logic model emerged through data synthesis and had face validity with service users. It combined an incentive typology and behaviour change taxonomy. Autonomy and well-being matter. Personal difficulties, emotions, socialising and attitudes of others are challenges to climbing a metaphorical ‘ladder’ towards smoking cessation and breastfeeding. Incentive interventions provide opportunity ‘rungs’ to help, including regular skilled flexible support, a pal, setting goals, monitoring and outcome verification. Individually tailored and non-judgemental continuity of care can bolster women’s capabilities to succeed. Rigid, prescriptive interventions placing the onus on women to behave ‘healthily’ risk them feeling pressurised and failing. To avoid ‘losing face’, women may disengage. Limitations: Included studies were heterogeneous and of variable quality, limiting the assessment of incentive effectiveness. No cost-effectiveness data were reported. In surveys, selection bias and confounding are possible. The validity and utility of the ladder logic model requires evaluation with more diverse samples of the target population. Conclusions: Incentives provided with other tailored components show promise but reach is a concern. Formal evaluation is recommended. Collaborative service-user involvement is importan
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