Preventing Suicide in Colorado: Progress Achieved & Goals for the Future

This 2009 report, issued jointly by Mental Health America of Colorado and The Colorado Trust, updates both the state's 1998 Suicide Prevention and Intervention Plan to address Colorado's historically high suicide rate, as well as The Trust's 2002 report Suicide in Colorado, which documented the problem of suicide across the state and identified suicide-prevention resources. This report details key facts and figures about the suicide rate in Colorado, many of the prevention achievements in the past 10 years, and recommendations to strengthen suicide prevention and awareness efforts into the future

The Clinical Effectiveness of Using Kinesio Tape Following Wisdom Teeth Extraction

Surgical removal of third molars (3M) is a routine, low risk procedure. Common post-surgical symptoms are typically swelling, pain and trismus. Kinesiology Taping (KT) is a relatively new treatment option in musculoskeletal pathologies and some of the hypotheses of KT is that it reduces pain, oedema and increases blood flow; however current evidence does not support its use. Patient A underwent a routine removal of 3 third molars via general anaesthetic. A post-surgical lymphatic drainage KT application was applied to the patient’s lower mandible and masseter region. Results showed a significant reduction in pain, swelling and trismus was also reduced. The post op recovery time was decreased from the post op material of 10 days to 5 days; therefore suggesting that KT is potentially an effective treatment following surgical removal of wisdom teeth

Student resilience : exploring the positive case for resilience

Resilience is a word that is increasingly being used alongside student welfare, but what is meant by resilience? This paper takes a closer look at the subject of student resilience and I hope will encourage greater debate, exploration and fresh perspectives. As the paper outlines, while the study of student resilience is still very much in its infancy in the UK, there is recognition that student mental wellbeing is a growing challenge, and one which needs greater consideration. While overall student satisfaction at UK universities is rightly high, it has become clear that not all students find the transition to university life a straightforward one. Unite Students provides a home to around 50,000 students across the UK and our own research findings from the past few years demonstrate that some students can and do face difficulties. This is what prompted us to dedicate a significant portion of our annual Unite Students Insight Report in 2016 to finding out more about students’ own views on resilience by trying to identify some of the challenges surrounding student mental health, isolation and stress. These research insights support the detailed operational data from which we and our partner universities have seen an increase in welfare-related incidents over the last two years, and which encourage us to continually review and improve our operational processes and support services

Beyond the Checklist Approach: A Librarian-Faculty Collaboration to Teach the BEAM Method of Source Evaluation

Evaluating information is an essential skill, valued across disciplines. While librarians and instructors share the responsibility to teach this skill, they need a common framework in order to collaborate to design assignments that give students multiple opportunities to learn. Librarians and First Year Seminar faculty at Belmont University collaborated to design a unit of instruction on source evaluation using the BEAM method. BEAM requires students to apply a use-based approach to evaluation, to read and engage with sources more closely, and to think about how they might use a source for a specific purpose. Structured annotated bibliographies that included BEAM were assessed, along with student, instructor, and librarian feedback. The BEAM method may be an effective method for teaching information evaluation when paired with other sequenced assignments that guide students through the research and writing process

Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2

Although the insulin receptor substrate (IRS) proteins IRS1 and IRS2 share considerable homology and activate common signaling pathways, their contributions to breast cancer are distinct. IRS1 has been implicated in the proliferation and survival of breast tumor cells. In contrast, IRS2 facilitates glycolysis, invasion, and metastasis. To determine the mechanistic basis for IRS2-dependent functions, we investigated unique structural features of IRS2 that are required for invasion. Our studies revealed that the ability of IRS2 to promote invasion is dependent upon upstream insulin-like growth factor 1 receptor (IGF-1R)/insulin receptor (IR) activation and the recruitment and activation of phosphatidylinositol 3-kinase (PI3K), functions shared with IRS1. In addition, a 174-amino-acid region in the IRS2 C-terminal tail, which is not conserved in IRS1, is also required for IRS2-mediated invasion. Importantly, this invasion (INV) region is sufficient to confer invasion-promoting ability when swapped into IRS1. However, the INV region is not required for the IRS2-dependent regulation of glucose uptake. Bone morphogenetic protein 2-inducible kinase (BMP2K) binds to the INV region and contributes to IRS2-dependent invasion. Taken together, our data advance the mechanistic understanding of how IRS2 regulates invasion and reveal that IRS2 functions important for cancer can be independently targeted without interfering with the metabolic activities of this adaptor protein

The prevalence of severe personality disorder in perpetrators of homicide

Background: Current UK evidence on the prevalence of personality disorder in homicide is lacking. The aims were to estimate the prevalence of personality disorder in homicide perpetrators from court reports and carry out a dimensional assessment in keeping with the new ICD-11 classification of the prevalence of severe personality disorder. Associations between severe personality disorder and sociodemographic, historical and offence-related characteristics were then explored. Methods: Six hundred court reports from a national case series of homicide perpetrators in England and Wales were analysed using a document-derived version of the Personality Assessment Schedule (PAS-DOC), providing categorical and dimensional personality assessments. The prevalence of personality disorder and severe personality disorder was estimated. Factors associated with the diagnosis of severe personality disorder were examined. Results: The prevalence of personality disorder using the PAS-DOC was 56.3% (95% confidence interval 52.3%, 60.3%), compared with 16% as diagnosed in reports. Severe personality disorder was present in 62% (n = 338) of all those with a personality disorder and was significantly associated with homicides of strangers and previous violence. Conclusions: Severe personality disorder is highly prevalent among perpetrators of homicide, and the finding that it is more prevalent when strangers are the victims stresses both the need for early identification of those at risk of developing severe personality disorder and the development of appropriate early preventive interventions. There is also a need for the development of effective treatment and interventions for those with established severe personality disorder and better identification of this level of disorder by psychiatrists. The forthcoming ICD-11 classification should help in this endeavour

Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells

The insulin receptor substrate (IRS) proteins serve as essential signaling intermediates for the activation of PI3K by both the insulin-like growth factor 1 receptor (IGF-1R) and its close family member, the insulin receptor (IR). Although IRS-1 and IRS-2 share significant homology, they regulate distinct cellular responses downstream of these receptors and play divergent roles in breast cancer. To investigate the mechanism by which signaling through IRS-1 and IRS-2 results in differential outcomes, we assessed the involvement of the microtubule cytoskeleton in IRS-dependent signaling. Treatment with drugs that either stabilize or disrupt microtubules reveal that an intact microtubule cytoskeleton contributes to IRS-2- but not IRS-1-mediated activation of AKT by IGF-1. Proximal IGF-1R signaling events, including IRS tyrosine phosphorylation and recruitment of PI3K, are not inhibited by microtubule disruption, indicating that IRS-2 requires the microtubule cytoskeleton at the level of downstream effector activation. IRS-2 colocalization with tubulin is enhanced upon Taxol-mediated microtubule stabilization, which, together with the signaling data, suggests that the microtubule cytoskeleton may facilitate access of IRS-2 to downstream effectors such as AKT. Of clinical relevance is that our data reveal that expression of IRS-2 sensitizes breast carcinoma cells to apoptosis in response to treatment with microtubule-disrupting drugs, identifying IRS-2 as a potential biomarker for the response of breast cancer patients to Vinca alkaloid drug treatment

Kidney trajectory charts to assist general practitioners in the assessment of patients with reduced kidney function: a randomised vignette study

OBJECTIVE: To investigate the decisional impact of an age-based chart of kidney function decline to support general practitioners (GPs) to appropriately interpret estimated glomerular filtration rate (eGFR) and identify patients with a clinically relevant kidney problem. DESIGN AND SETTING: Randomised vignette study PARTICIPANTS: 372 Australian GPs from August 2018 to November 2018. INTERVENTION: GPs were given two patient case scenarios: (1) an older woman with reduced but stable renal function and (2) a younger Aboriginal man with declining kidney function still in the normal range. One group was given an age-based chart of kidney function to assist their assessment of the patient (initial chart group); the second group was asked to assess the patients without the chart, and then again using the chart (delayed chart group). MAIN OUTCOME MEASURES: GPs’ assessment of the likelihood—on a Likert scale—that the patients had chronic kidney disease (CKD) according to the usual definition or a clinical problem with their kidneys. RESULTS: Prior to viewing the age-based chart GPs were evenly distributed as to whether they thought case 1—the older woman—had CKD or a clinically relevant kidney problem. GPs who had initial access to the chart were less likely to think that the older woman had CKD, and less likely to think she had a clinically relevant problem with her kidneys than GPs who had not viewed the chart. After subsequently viewing the chart, 14% of GPs in the delayed chart group changed their opinion, to indicate she was unlikely to have a clinically relevant problem with her kidneys. Prior to viewing the chart, the majority of GPs (66%) thought case 2—the younger man—did not have CKD, and were evenly distributed as to whether they thought he had a clinically relevant kidney problem. In contrast, GPs who had initial access to the chart were more likely to think he had CKD and the majority (72%) thought he had a clinically relevant kidney problem. After subsequently viewing the chart, 37% of GPs in the delayed chart group changed their opinion to indicate he likely had a clinically relevant problem with his kidneys. CONCLUSIONS: Use of the chart changed GPs interpretation of eGFR, with increased recognition of the younger male patient’s clinically relevant kidney problem, and increased numbers classifying the older female patient’s kidney function as normal for her age. This study has shown the potential of an age-based kidney function chart to reduce both overdiagnosis and underdiagnosis