Electronic records management criteria and information Security

Records management practices are mandatory in many business and government operations. Records management is a mature discipline with extensive body of knowledge, professional associations and clearly defined Australian and international standards. Records systems encompass the hardware, software and people necessary for operation and include records generated by and for the system. The Australian legal system has clearly defined standards for admissible evidence in the Evidence Act. Relevant records may require substantial preparation for submission and yet be inadmissible in legal proceedings. The records and system may be challenged in both theoretical and practical senses and appropriate practices and associated records are needed. These records may be expensive to acquire, process and store in suitable format and retaining the original data may be necessary. Applying records from a system to problems outside of the initial system requirements and design may expose the system to attack by showing that it fails to meet good practice. Further, validation of the system may demand suitable records from every stage of the system lifecycle including theoretical and operational basis

Determining typical smartphone usage:What data do we need?

Problematic smartphone use is an emerging issue in behavioural addiction research. At the same time, measuring smartphone use with mobile apps has become increasingly common. However, understanding how much data is necessary requires careful consideration if the field is to move forward. Here, we examine how much time should be spent measuring mobile phone operation in order to reliably infer general patterns of usage and repetitive checking behaviours. In a second analysis, we consider whether a self-report measure of problematic smartphone use is associated with real-time patterns of use. Results suggest that smartphone usage collected for a minimum of five days will reflect typical weekly usage (in hours), but habitual checking behaviours (uses lasting less than 15 seconds) can be reliably inferred within two days. These measurements did not reliably correlate with a self-reported measure. We conclude that patterns of smartphone use are repetitive and our results suggest that checking behaviour is a particularly consistent and efficient measure when quantifying typical and problematic smartphone usage

Structural basis of mitochondrial receptor binding and constriction by DRP1.

Mitochondrial inheritance, genome maintenance and metabolic adaptation depend on organelle fission by dynamin-related protein 1 (DRP1) and its mitochondrial receptors. DRP1 receptors include the paralogues mitochondrial dynamics proteins of 49 and 51 kDa (MID49 and MID51) and mitochondrial fission factor (MFF); however, the mechanisms by which these proteins recruit and regulate DRP1 are unknown. Here we present a cryo-electron microscopy structure of full-length human DRP1 co-assembled with MID49 and an analysis of structure- and disease-based mutations. We report that GTP induces a marked elongation and rotation of the GTPase domain, bundle-signalling element and connecting hinge loops of DRP1. In this conformation, a network of multivalent interactions promotes the polymerization of a linear DRP1 filament with MID49 or MID51. After co-assembly, GTP hydrolysis and exchange lead to MID receptor dissociation, filament shortening and curling of DRP1 oligomers into constricted and closed rings. Together, these views of full-length, receptor- and nucleotide-bound conformations reveal how DRP1 performs mechanical work through nucleotide-driven allostery

Shaped nozzles for cryogenic buffer gas beam sources

Cryogenic buffer gas beams are important sources of cold molecules. In this work we explore the use of a converging-diverging nozzle with a buffer-gas beam. We find that, under appropriate circumstances, the use of a nozzle can produce a beam with improved collimation, lower transverse temperatures, and higher fluxes per solid angle

Evaluation of the dynamic construct competition miner for an eHealth system

Business processes of some domains are highly dynamic and increasingly complex due to their dependencies on a multitude of services provided by various providers. The quality of services directly impacts the business process’s efficiency. A first prerequisite for any optimization initiative requires a better understanding of the deployed business processes. However, the business processes are either not documented at all or are only poorly documented. Since the actual behaviour of the business processes and underlying services can change over time it is required to detect the dynamically changing behaviour in order to carry out correct analyses. This paper presents and evaluates the integration of the Dynamic Construct Competition Miner (DCCM) as process monitor in the TIMBUS architecture. The DCCM discovers business processes and recognizes changes directly from an event stream at run-time. The evaluation is carried out in the context of an industrial use-case from the eHealth domain. We will describe the key aspects of the use-case and the DCCM as well as present the relevant evaluation results

A novel role for BRCA1 in regulating breast cancer cell spreading and motility

BRCA1 interacts with ERM proteins at leading edges and focal adhesion sites and modulates motility via its ubiquitin ligase activity

Towards standard setting for patient-reported outcomes in the NHS homeopathic hospitals

We report findings from a pilot data collection study within a programme of quality assurance, improvement and development across all five homeopathic hospitals in the UK National Health Service (NHS).<p></p> <b>Aims</b> (1) To pilot the collection of clinical data in the homeopathic hospital outpatient setting, recording patient-reported outcome since first appointment; (2) to sample the range of medical complaints that secondary-care doctors treat using homeopathy, and thus identify the nature and complexity of complaints most frequently treated nationally; (3) to present a cross section of outcome scores by appointment number, including that for the most frequently treated medical complaints; (4) to explore approaches to standard setting for homeopathic practice outcome in patients treated at the homeopathic hospitals.<p></p> <b>Methods</b> A total of 51 medical practitioners took part in data collection over a 4-week period. Consecutive patient appointments were recorded under the headings: (1) date of first appointment in the current series; (2) appointment number; (3) age of patient; (4) sex of patient; (5) main medical complaint being treated; (6) whether other main medical complaint(s); (7) patient-reported change in health, using Outcome Related to Impact on Daily Living (ORIDL) and its derivative, the ORIDL Profile Score (ORIDL-PS; range, –4 to +4, where a score ≤−2 or ≥+2 indicates an effect on the quality of a patient's daily life); (8) receipt of other complementary medicine for their main medical complaint.<p></p> <b>Results</b> The distribution of patient age was bimodal: main peak, 49 years; secondary peak, 6 years. Male:female ratio was 1:3.5. Data were recorded on a total of 1797 individual patients: 195 first appointments, 1602 follow-ups (FUs). Size of clinical service and proportion of patients who attended more than six visits varied between hospitals. A total of 235 different medical complaints were reported. The 30 most commonly treated complaints were (in decreasing order of frequency): eczema; chronic fatigue syndrome (CFS); menopausal disorder; osteoarthritis; depression; breast cancer; rheumatoid arthritis; asthma; anxiety; irritable bowel syndrome; multiple sclerosis; psoriasis; allergy (unspecified); fibromyalgia; migraine; premenstrual syndrome; chronic rhinitis; headache; vitiligo; seasonal allergic rhinitis; chronic intractable pain; insomnia; ulcerative colitis; acne; psoriatic arthropathy; urticaria; ovarian cancer; attention-deficit hyperactivity disorder (ADHD); epilepsy; sinusitis. The proportion of patients with important co-morbidity was higher in those seen after visit 6 (56.9%) compared with those seen up to and including that point (40.7%; P < 0.001). The proportion of FU patients reporting ORIDL-PS ≥ +2 (improvement affecting daily living) increased overall with appointment number: 34.5% of patients at visit 2 and 59.3% of patients at visit 6, for example. Amongst the four most frequently treated complaints, the proportion of patients that reported ORIDL-PS ≥ +2 at visit numbers greater than 6 varied between 59.3% (CFS) and 73.3% (menopausal disorder).<p></p> <b>Conclusions</b> We have successfully piloted a process of national clinical data collection using patient-reported outcome in homeopathic hospital outpatients, identifying a wide range and complexity of medical complaints treated in that setting. After a series of homeopathy appointments, a high proportion of patients, often representing “effectiveness gaps” for conventional medical treatment, reported improvement in health affecting their daily living. These pilot findings are informing our developing programme of standard setting for homeopathic care in the hospital outpatient context

Interannual variability in glacier contribution to runoff from a high-elevation Andean catchment: understanding the role of debris cover in glacier hydrology

We present a field‐data rich modelling analysis to reconstruct the climatic forcing, glacier response, and runoff generation from a high‐elevation catchment in central Chile over the period 2000–2015 to provide insights into the differing contributions of debris‐covered and debris‐free glaciers under current and future changing climatic conditions. Model simulations with the physically based glacio‐hydrological model TOPKAPI‐ETH reveal a period of neutral or slightly positive mass balance between 2000 and 2010, followed by a transition to increasingly large annual mass losses, associated with a recent mega drought. Mass losses commence earlier, and are more severe, for a heavily debris‐covered glacier, most likely due to its strong dependence on snow avalanche accumulation, which has declined in recent years. Catchment runoff shows a marked decreasing trend over the study period, but with high interannual variability directly linked to winter snow accumulation, and high contribution from ice melt in dry periods and drought conditions. The study demonstrates the importance of incorporating local‐scale processes such as snow avalanche accumulation and spatially variable debris thickness, in understanding the responses of different glacier types to climate change. We highlight the increased dependency of runoff from high Andean catchments on the diminishing resource of glacier ice during dry years