POWDER SOLUTION TECHNOLOGY REVIEW

Bioavailability and Solubility are the challenges for the formulation of highly lipophilic drugs. Oral routes of administration is one of the acceptable route due to improved patient compliance and convenience. Regularly newly advanced drug candidates are lipophilic, BCS Class II and IV drugs. Among various methods to improve the solubility of these drugs, liquid-solid technology or Powdered solution technology change the liquid drug into non-sticky, dry free-flowing, rapid release powder. This technique involves mixing of insoluble drug with nonvolatile solvent, admixing of drug-loaded excipients change into loose powder. This technique enhances major challenges like bioavailability with low production cost and a simple manufacturing process

A review on recent advancement in liquisolid techology

Liquisolid technique is a novel process in which a liquid can be converted into a material that flows freely, is readily compressible. The carrier material in liquisolid compact comprises the liquid part, which is the liquid drug or a drug solution in liquid vehicles that are non-volatile. Solubility is the main parameter in the circulation of blood to achieve the whole concentration of the drug for pharmacological action. The rate of dissolution of drugs enhances in liquisolid technology. This in turn increases absorption and bioavailability subsequently. This review discusses the different advances and changes to improve liquisolid technology formulations and enhancement of dissolution rate of poorly soluble drugs. Most of the new chemical entities have high lipophilicity and poor water solubility, resulting in poor bioavailability. The release rate of these drugs should be increased in order to improve bioavailability. The technique is based on dissolving the insoluble drug in the solution loaded with non-volatile solvent. Then the dissolution rate of drug which is poorly soluble will rise. The enhanced bioavailability is due to the increased surface area of drug for release, increased drug aqueous solubility or improved wetting capacity

MICROFLUIDIC DEVICES AS A TOOL FOR DRUG DELIVERY AND DIAGNOSIS: A REVIEW

Microfluidic devices are a good example of the collaboration of chemical, biological, and engineering sciences. Microfluidic devices emerge as an in fluent technology which provides an alternative to conventional laboratory methods. These devices are employed for the precise handling and transport precise quantities of drugs without toxicity. This system is emerging as a promising platform for designing advanced drug delivery systems and analysis of biological phenomena on miniature devices for easy diagnosis. Microfluidics enables the fabrication of drug carriers with controlled geometry and specific target sites. Microfluidic devices are also used for the diagnosis of cancer circulating tumor cells. In the current review, different microfluidic drug delivery systems and diagnostic devices have described

Short review on domperidone tablet

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Pediatric and geriatric patients find it difficult to swallow solid dosage forms like tablets. Mouth dissolving tablet that dissolve or disintegrate rapidly in oral cavity result in solution, is an ultimate remedy for this problem in addition they give pleasing mouth feeling. ODT has advantages such as patient compliance, quick onset of action, improved bioavailability. Domperidone tablet (ODT) gives relief from nausea, vomiting. This review gives us all information about pharmacokinetic, pharmacodynamic, uses, precautions, side effects of domperidone tablet

An Automatic Segmentation & Detection of Blood Vessels and Optic Disc in Retinal Images

Conceptual Segmentation is a critical technique in medical imaging. The Processes of identification and division of optic circle and veins are the fundamental strides for the analysis of a few infections that causes visual deficiency like diabetic retinopathy, hypertension, glaucoma and different visual deficiency ailment

Comparative Study of Ni and Cu Doped Zno Nanoparticles: Structural and Optical Properties

Nanoparticles of undoped and doped (0.1 M Ni2+ and Cu2+) ZnO are synthesized using chemical precipitation method. The crystallite size, morphology, chemical bonding and optical properties of as prepared nanoparticles are determined by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and UV-visible spectra. XRD analysis shows that the prepared samples are single phase and have hexagonal wurtzite structure. The crystallite size of the doped and undoped nanoparticles is determined using Scherrer method. The crystallite size is found to be increased with concentration of nickel and copper. All stretching and vibrational bands are observed at their specific positions through FTIR. The increase in band gap can be attributed to the different chemical nature of dopant and host cation

Review of WiMax Services & Security Threats

Abstract-No

Determination of Multiple Spring Constants, Gaps and Pull Down Voltages in MEMS CRAB Type Microaccelerometer Using Near Pull Down Capacitance Voltage Measurements

A simple experimental method based on capacitance voltage (CV) measurements is presented to extract the spring constants (k) different actuation voltages and gaps, in crab type capacitive MEMS accelerometer sensors. It is shown that in addition to main spring action provided by the legs of the structure, the additional spring constants related to the interaction of main spring-proof mass joint and corner region of the proof mass also contribute to change in capacitance. The proposed approach is used in resolving and measuring these model parameters simultaneously because all of them can be extracted from the just one CV measurement. It is found that this additional k varies by more than a factor of 10 across the 6-inch wafer. Furthermore, zero bias capacitance C0, zero bias gap g0, main spring constant k and initial pull down voltage Vpd1 vary by factors of 2.4, 2.38, 30 and 3 respectively. The method also allows us to extract different values of pull down and spring constants associated with different regions of crab structure. The experimental results agree well with the theoretical predictions and reported trends in literatures. The method is routinely applied while fabricating the actual prototype sensors fabricated in our laboratory