БЕСКИСЛОТНЫЙ МЕТОД ПЕРЕРАБОТКИ ФОСФОРИТОВ (БАССЕЙН КАРАТАУ) В КОМПЛЕКСНЫЕ УДОБРЕНИЯ

The choice of the Karatau phosphorites (The Republic of Kazakhstan) as a perspective phosphorus-containing raw material for Belarusian producers is substantiated. The process of activation of phosphate of the Zhanatas deposit (Karatau basin (Kazakhstan)) in a drum ball mill, a dismembrator and a vibratory mill was researched. The influence of solid potassium- and nitrogen-containing components (potassium chloride, ammonium sulfate, urea) on the activability of the phosphorites has been studied. Under optimum conditions more than 60 % of P2 O5 of phosphorite can be transferred to the digestible form by the “dry” method, which is a prerequisite for the development of a non-waste and environmentally safe technology for the production of NPK fertilizers.Обоснован выбор фосфоритов бассейна Каратау Республики Казахстан в качестве перспективного фосфорсодержащего сырья для производителей Беларуси. Изучен процесс активации фосфоритов месторождения Жанатас бассейна Каратау (Казахстан) в барабанной шаровой мельнице, дисмембраторе и вибрационной мельнице. Исследовано влияние на активируемость фосфатного сырья твердых калий- и азотсодержащих компонентов (хлорид калия, сульфат аммония, карбамид). В оптимальных условиях в усвояемую форму «сухим» методом может быть переведено свыше 60 % Р2 О5 фосфорита, что является предпосылкой для разработки безотходной и экологически безопасной технологии производства NPK-удобрений

Additional Impact of Glucose Tolerance on Telomere Length in Persons With and Without Metabolic Syndrome in the Elderly Ukraine Population

Rationale: Association between different components of metabolic syndrome and the rate of age-related telomere shortening was reported repeatedly, although some findings are inconsistent across studies, suggesting the need for further research on the topic. In the present study, we examined relationships between different components of metabolic syndrome (MetS); glucose tolerance reflected in 2-h post-load plasma glucose (2hPG) levels and age on the leukocyte telomere length (LTL) in Ukraine population.Methods: The study was conducted on the 115 adult individuals residing in the Kyiv region (Ukraine). Among them, 79 were diagnosed with MetS according to the International Diabetes Federation definition. LTL were determined by a qPCR-based method. Multivariate logistic regression (MLR) and artificial neural networks (ANN) modeling were used for the analysis of the results. ROC-analysis was also performed to compare the predictively values of this models.Results: MetS was associated with a high (OR = 3.0 CI 1.3–6.7; p = 0.01) risk of having shorter telomeres that remained significant after adjusting for age, gender and 2hPG levels. Fasting plasma glucose (FPG) levels and other MetS components did not affect the magnitude of the relationship and did not reveal the independent influence of these factors. The level of 2hPG in turn, demonstrated a significant relationship (OR = 1.3 CI 1.0–1.6 per 1 mmol/l; p = 0.04) with LTL regardless of the presence of MetS. The non-linearity of the interactions between age, gender and 2hPG level was revealed by neural network modeling (AUC = 0.76 CI 0.68–0.84).Conclusion: Our study found that impaired glucose tolerance, but not FPG levels, affected the association between LTL and MetS, which may be also indicative for pathophysiological differences in these hyperglycemia categories. 2hPG levels can provide an opportunity for a more accurate diagnostics of MetS and for evaluating the rate of aging in patients with MetS. Further research, however, is needed to verify this assumption

Mechanical Activation of the Phosphorites (Karatau Pool) by using Organic-Mineral Co-Activators for Multicomponent Mineral Fertilizers

Deficiency of mineral fertilizers in the agricultural sector for last 15–20 years has decreased. Therefore with the purpose of partial reduction of this deficiency it was developed a new polycomponent NPK fertilizer, which contains humate and vermiculite. The given fertilizer has been produced from the natural South Kazakhstan raw materials in accordance with an acid-free way. The given article contains the data and physicochemical properties of initial materials prepared on the basis of phosphorite fines of Zhanatas and Chulaktau deposits and sinter return. Characteristics of vermiculite and the internal overburden rocks formed at the mining brown coal on the Lenger deposit are represented. During the experimental research except the above-stated natural raw materials the following substances were used at manufacture of the polycomponent fertilizer: ammonia saltpeter, ammonium sulphate produced by the OJSC “Grodno-Azot”, halurgical potassium chloride produced by “Belaruskaliy” and potassium hydroxide, a chemical reagent of a grade “pure”. The given article contains the data about the chemical composition of initial raw materials and conditions of mechanical-chemical activation of the initial materials at various values of components concentration, temperature and time at the polycomponent fertilizer manufacture. The plan and research results of phosphorite’s activation with the analysis of a disperse structure of nonactivated and activated Zhanatas phosphorite are represented. The determination of nonactivated and activated phosphorites specific surface was performed with use of a device PSH-8A according to the method based on the measurement of hydraulic resistance of a powder material’s layer at filtration of an air low-pressure stream

Mechanical Activation of the Phosphorites (Karatau Pool) by using Organic-Mineral Co-Activators for Multicomponent Mineral Fertilizers

Deficiency of mineral fertilizers in the agricultural sector for last 15–20 years has decreased. Therefore with the purpose of partial reduction of this deficiency it was developed a new polycomponent NPK fertilizer, which contains humate and vermiculite. The given fertilizer has been produced from the natural South Kazakhstan raw materials in accordance with an acid-free way. The given article contains the data and physicochemical properties of initial materials prepared on the basis of phosphorite fines of Zhanatas and Chulaktau deposits and sinter return. Characteristics of vermiculite and the internal overburden rocks formed at the mining brown coal on the Lenger deposit are represented. During the experimental research except the above-stated natural raw materials the following substances were used at manufacture of the  polycomponent fertilizer: ammonia saltpeter, ammonium sulphate produced by the OJSC “Grodno-Azot”, halurgical potassium chloride produced by “Belaruskaliy” and potassium hydroxide, a chemical reagent of a grade “pure”. The given article contains the data about the chemical composition of initial raw materials and conditions of mechanical-chemical activation of the initial materials at various values of components concentration, temperature and time at the polycomponent fertilizer manufacture. The plan and research results of phosphorite’s activation with the analysis of a disperse structure of nonactivated and activated Zhanatas phosphorite are represented. The determination of nonactivated and activated phosphorites specific surface was performed with use of a device PSH-8A according to the method based on the measurement of hydraulic resistance of a powder material’s layer at filtration of an air low-pressure stream

Edoxaban versus warfarin in patients with atrial fibrillation

Contains fulltext : 125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)

Cytoprotection by Melatonin: The Metabolic Syndrome as an Example

Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, in part because of its function as a metabolic regulator and mitochondrial protector. As a chronobiotic/cytoprotective agent, melatonin may occupy a special place in the prevention and treatment of metabolic syndrome.Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentin