Physical Results from Unphysical Simulations

We calculate various properties of pseudoscalar mesons in partially quenched QCD using chiral perturbation theory through next-to-leading order. Our results can be used to extrapolate to QCD from partially quenched simulations, as long as the latter use three light dynamical quarks. In other words, one can use unphysical simulations to extract physical quantities - in this case the quark masses, meson decay constants, and the Gasser-Leutwyler parameters L_4-L_8. Our proposal for determining L_7 makes explicit use of an unphysical (yet measurable) effect of partially quenched theories, namely the double-pole that appears in certain two-point correlation functions. Most of our calculations are done for sea quarks having up to three different masses, except for our result for L_7, which is derived for degenerate sea quarks.Comment: 26 pages, 12 figures (discussion on discretization errors at end of sec. IV clarified; minor improvements in presentation; results unchanged

Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production

EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright. Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or figures copyrighted by other commercial organizations and individuals that may not be used without obtaining prior approval from both the EHP editors and the holder of the copyright. Use of any materials published in EHP should be acknowledged (for example, "Reproduced with permission from Environmental Health Perspectives") and a reference provided for the article from which the material was reproduced.This study assessed whether exposure of male rats to two estrogenic, environmental chemicals, 4-octylphenol (OP) and butyl benzyl phthalate (BBP) during gestation or during the first 21 days of postnatal life, affected testicular size or spermatogenesis in adulthood (90-95 days of age). Chemicals were administered via the drinking water or concentrations of 10-1000 micrograms/l (OP) or 1000 micrograms/l (BBP), diethylstilbestrol (DES; 100 micrograms/l) and an octylphenol polyethoxylate (OPP; 1000 micrograms/l), which is a weak estrogen or nonestrogenic in vitro, were administered as presumptive positive and negative controls, respectively. Controls received the vehicle (ethanol) in tap water. In study 1, rats were treated from days 1-22 after births in studies 2 and 3, the mothers were treated for approximately 8-9 weeks, spanning a 2-week period before mating throughout gestation and 22 days after giving birth. With the exception of DES, treatment generally had no major adverse effect or body weight: in most instances, treated animals were heavier than controls at day 22 and at days 90-95. Exposure to OP, OPP, or BBP at a concentration of 1000 micrograms/1 resulted in a small (5-13%) but significant (p < 0.01 or p < 0.0001) reduction in mean testicular size in studies 2 and 3, an effect that was still evident when testicular weight was expressed relative to body, weight or kidney weight. The effect of OPP is attributed to its metabolism in vivo to OP. DES exposure caused similar reductions in testicular size but also caused reductions in body weight, kidney weight, and litter size. Ventral prostate weight was reduced significantly in DES-treated rats and to minor extent in OP-treated rats. Comparable but more minor effects of treatment with DES or OP on testicular size were observed in study 1. None of the treatments had any adverse effect on testicular morphology or on the cross-sectional area of the lumen or seminiferous epithelium at stages VII-VIII of the spermatogenic cycle, but DES, OP, and BBP caused reductions of 10-21% (p < 0.05 to p < 0.001) in daily sperm production. Humans are exposed to phthalates, such as BBP, and to alkylphenol polyethoxylates, such as OP, but to what extent is unknown. More detailed studies are warranted to assess the possible risk to the development of the human testis from exposure to these and other environmental estrogens

Partially quenched chiral perturbation theory without Φ0\Phi_0

This paper completes the argument that lattice simulations of partially quenched QCD can provide quantitative information about QCD itself, with the aid of partially quenched chiral perturbation theory. A barrier to doing this has been the inclusion of $\Phi_0$, the partially quenched generalization of the $\eta'$, in previous calculations in the partially quenched effective theory. This invalidates the low energy perturbative expansion, gives rise to many new unknown parameters, and makes it impossible to reliably calculate the relation between the partially quenched theory and low energy QCD. We show that it is straightforward and natural to formulate partially quenched chiral perturbation theory without $\Phi_0$, and that the resulting theory contains the effective theory for QCD without the $\eta'$. We also show that previous results, obtained including $\Phi_0$, can be reinterpreted as applying to the theory without $\Phi_0$. We contrast the situation with that in the quenched effective theory, where we explain why it is necessary to include $\Phi_0$. We also compare the derivation of chiral perturbation theory in partially quenched QCD with the standard derivation in unquenched QCD. We find that the former cannot be justified as rigorously as the latter, because of the absence of a physical Hilbert space. Finally, we present an encouraging result: unphysical double poles in certain correlation functions in partially quenched chiral perturbation theory can be shown to be a property of the underlying theory, given only the symmetries and some plausible assumptions.Comment: 45 pages, no figure

A unified design space of synthetic stripe-forming networks

Synthetic biology is a promising tool to study the function and properties of gene regulatory networks. Gene circuits with predefined behaviours have been successfully built and modelled, but largely on a case-by-case basis. Here we go beyond individual networks and explore both computationally and synthetically the design space of possible dynamical mechanisms for 3-node stripe-forming networks. First, we computationally test every possible 3-node network for stripe formation in a morphogen gradient. We discover four different dynamical mechanisms to form a stripe and identify the minimal network of each group. Next, with the help of newly established engineering criteria we build these four networks synthetically and show that they indeed operate with four fundamentally distinct mechanisms. Finally, this close match between theory and experiment allows us to infer and subsequently build a 2-node network that represents the archetype of the explored design space

Steady non-ideal detonations in cylindrical sticks of expolsives

Numerical simulations of detonations in cylindrical rate-sticks of highly non-ideal explosives are performed, using a simple model with a weakly pressure dependent rate law and a pseudo-polytropic equation of state. Some numerical issues with such simulations are investigated, and it is shown that very high resolution (hundreds of points in the reaction zone) are required for highly accurate (converged) solutions. High resolution simulations are then used to investigate the qualitative dependences of the detonation driving zone structure on the diameter and degree of confinement of the explosive charge. The simulation results are used to show that, given the radius of curvature of the shock at the charge axis, the steady detonation speed and the axial solution are accurately predicted by a quasi-one-dimensional theory, even for cases where the detonation propagates at speeds significantly below the Chapman-Jouguet speed. Given reaction rate and equation of state models, this quasi-one-dimensional theory offers a significant improvement to Wood-Kirkwood theories currently used in industry

Design of Autonomous Medical Response Agent (AMRA) Aggregate Information Dashboard (AID)

Future astronauts in deep space missions will rely on tools and technologies empowering them to self-diagnose and self-treat medical conditions. Given communications delays and limited bandwidth in future long-duration exploration missions (LDEMs), medical decision support technologies must empower the crew to manage routine medical activities, acute medical incidents, as well as emergency medical scenarios independently from ground support.The Autonomous Medical Response Agent (AMRA) is envisioned as a digital tool enabling crew to issue medical complaints and interact with a medical decision support algorithm which develops a differential diagnosis and recommends a treatment protocol for the condition. AMRA will draw from individual crew medical history in addition to crew symptoms to more efficiently identify high-risk medical conditions. A new symptom could be indicative of a chronic condition or a normal adaptation to long-duration spaceflight, but could just as easily be indicative of an adverse vehicle condition affecting the entire crew.While real-time communication with a flight surgeon may not possible, the crew will nonetheless require a means to communicate and document both routine and emergency medical incidents to ground support. Conversely, flight surgeons and medical specialists on the ground will need to understand information such as crew vitals or responses to medical check-ups and examinations within the larger context of crew schedule, mission activities, and vehicle performance. A user interface which establishes communication protocols between an individual crew member and AMRA, as well as ground support to the crew is a significant area of research demanding input and consideration.The design of AMRA AID is intended to: a) represent routine medical activities as well as new (unplanned) medical incidents within the larger context of crew schedule and mission activities, and b) increase confidence between ground support and crew members over the course of LDEMs. Maintaining situation awareness of unplanned medical incidents between ground and crew will be a critical element within LDEMs. Two medical incidents headache and difficulty breathing are being explored within a user interface prototype which captures communications protocols between crew members and mission control, human health monitoring, vehicle or environmental monitoring, as well as crew schedule and mission activities holistically

Heavy-Meson Observables at One-Loop in Partially Quenched Chiral Perturbation Theory

I present one-loop level calculations of the Isgur-Wise functions for B -> D^{(*)} + e + nu, of the matrix elements of isovector twist-2 operators in B and D mesons, and the matrix elements for the radiative decays D^* -> D + gamma in partially quenched heavy quark chiral perturbation theory. Such expressions are required in order to extrapolate from the light quark masses used in lattice simulations of the foreseeable future to those of nature.Comment: 13 pages, 3 fig

Unphysical Operators in Partially Quenched QCD

We point out that the chiral Lagrangian describing pseudo-Goldstone bosons in partially quenched QCD has one more four-derivative operator than that for unquenched QCD with three flavors. The new operator can be chosen to vanish in the unquenched sector of the partially quenched theory. Its contributions begin at next-to-leading order in the chiral expansion. At this order it contributes only to unphysical scattering processes, and we work out some examples. Its contributions to pseudo-Goldstone properties begin at next-to-next-to-leading order, and we determine their form. We also determine all the zero and two derivative operators in the $O(p^6)$ partially quenched chiral Lagrangian, finding three more than in unquenched QCD, and use these to give the general form of the analytic next-to-next-to-leading order contributions to the pseudo-Goldstone mass and decay constant. We discuss the general implications of such additional operators for the utility of partially quenched simulationsComment: 13 pages, 11 figures Version 2: Additional footnote and parenthesis in section

Impact of the finite volume effects on the chiral behavior of fK and BK

We discuss the finite volume corrections to fK and BK by using the one-loop chiral perturbation theory in full, quenched, and partially quenched QCD. We show that the finite volume corrections to these quantities dominate the physical (infinite volume) chiral logarithms.Comment: 16 pages, 3 figures [published version