Chemical Equilibrium Abundances in Brown Dwarf and Extrasolar Giant Planet Atmospheres

We calculate detailed chemical abundance profiles for a variety of brown dwarf and extrasolar giant planet atmosphere models, focusing in particular on Gliese 229B, and derive the systematics of the changes in the dominant reservoirs of the major elements with altitude and temperature. We assume an Anders and Grevesse (1989) solar composition of 27 chemical elements and track 330 gas--phase species, including the monatomic forms of the elements, as well as about 120 condensates. We address the issue of the formation and composition of clouds in the cool atmospheres of substellar objects and explore the rain out and depletion of refractories. We conclude that the opacity of clouds of low--temperature ($\le$900 K), small--radius condensibles (specific chlorides and sulfides), may be responsible for the steep spectrum of Gliese 229B observed in the near infrared below 1 \mic. Furthermore, we assemble a temperature sequence of chemical transitions in substellar atmospheres that may be used to anchor and define a sequence of spectral types for substellar objects with T$_{eff}$s from $\sim$2200 K to $\sim$100 K.Comment: 57 pages total, LaTeX, 14 figures, 5 tables, also available in uuencoded, gzipped, and tarred form via anonymous ftp at www.astrophysics.arizona.edu (cd to pub/burrows/chem), submitted to Ap.

The Effect of Bundled Payment on Emergency Department Use: Alternative Quality Contract Effects After Year One

ObjectivesThe objective was to identify the effect of the Alternative Quality Contract (AQC), a global payment system implemented by Blue Cross Blue Shield (BCBS) of Massachusetts in 2009, on emergency department (ED) presentations.MethodsBlue Cross Blue Shield of Massachusetts claims from 2006 through 2009 for 332,624 enrollees whose primary care physicians (PCPs) enrolled in the AQC, and 1,296,399 whose PCPs were not enrolled in the AQC, were evaluated. A pre–post, intervention–control, propensity‐scored difference‐in‐difference approach was used to isolate the AQC effect on ED visits. The analysis adjusted for age, sex, health status, and secular trends to compare ED use between the treatment and control groups.ResultsOverall, secular trends showed that the number of ED visits decreased slightly for both treatment and control groups. The adjusted analysis of the AQC group showed decreases from 0.131 to 0.127 visits per member/quarter, and the control group decreased from 0.157 to 0.152 visits per member/quarter. The difference‐in‐difference analysis showed the AQC had no statistically significant effect on total ED use compared to the control group.ConclusionsIn the first year of this AQC, we did not find evidence of change in aggregate ED use. Similar global budget programs may not alter ED use in the initial implementation period.ResumenEfecto del Pago Combinado en el Uso del Servicio de Urgencias: Los Efectos del Alternative Quality Contract tras un AñoObjetivosIdentificar el efecto del Alternative Quality Contract (AQC), un sistema de pago global implementado por el Blue Cross Blue Shield de Massachusetts en 2009, en las visitas a los servicios de urgencias (SU).MetodologíaSe evaluaron los 332.624 miembros cuyo médico de atención primaria (MAP) estaba incluido en el AQC y los 1.296.399 cuyo MAP no estaba incluido en el AQC del Blue Cross Blue Shield de Massachusetts de 2006 hasta 2009. Para identificar el efecto del AQC en las visitas al SU, se utilizó un diseño pre‐post, intervención‐control, con una aproximación por puntuación de propensión diferencia en diferencia. El análisis se ajustó por edad, sexo, estado de salud y tendencias seculares para comparar el uso del SU entre los grupos tratamiento y control.ResultadosDel total, las tendencias seculares mostraron que el número de visitas al SU descendió discretamente tanto para el grupo tratamiento como control. El análisis ajustado del grupo AQC mostró un descenso de 0,131 a 0,127 visitas por miembro/cuartil, y el grupo control descendió de 0,157 a 0,152 visitas por miembro/cuartil. El análisis de diferencia en diferencia mostró que el AQC no tuvo efecto estadísticamente significativo en el uso total del SU en comparación con el grupo control.ConclusionesEn su primer año, el AQC no tuvo un efecto significativo en el uso del SU. PLos programas económicos globales similares pueden no alterar la utilización del SU en el periodo inicial de implementación.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/112205/1/acem12205-sup-0001-DataSupplementS1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/112205/2/acem12205.pd

Line Intensities and Molecular Opacities of the FeH F4Δi−X4ΔiF^4\Delta_i-X^4\Delta_i Transition

We calculate new line lists and opacities for the $F^4\Delta_i-X^4\Delta_i$ transition of FeH. The 0-0 band of this transition is responsible for the Wing-Ford band seen in M-type stars, sunspots and brown dwarfs. The new Einstein A values for each line are based on a high level ab initio calculation of the electronic transition dipole moment. The necessary rotational line strength factors (H\"onl-London factors) are derived for both the Hund's case (a) and (b) coupling limits. A new set of spectroscopic constants were derived from the existing FeH term values for v=0, 1 and 2 levels of the $X$ and $F$ states. Using these constants extrapolated term values were generated for v=3 and 4 and for $J$ values up to 50.5. The line lists (including Einstein A values) for the 25 vibrational bands with v$\leq$4 were generated using a merged list of experimental and extrapolated term values. The FeH line lists were use to compute the molecular opacities for a range of temperatures and pressures encountered in L and M dwarf atmospheres. Good agreement was found between the computed and observed spectral energy distribution of the L5 dwarf 2MASS-1507.Comment: 52 pages, 3 figures, many tables, accepted for publication in the Astrophysical Journal Supplement

One small step for man, one giant leap for men's health: A meta-analysis of behaviour change interventions to increase men's physical activity

Objective To determine the effects of behaviour change interventions on men’s physical activity (postintervention), sustained change in physical activity behaviour (≥12 months postintervention) and to identify variations in effects due to potential moderating variables (eg, theoretical underpinning, gender-tailored, contact frequency). Design Systematic review with meta-analysis. Pooled effect size (Cohen’s d) was calculated assuming a random-effects model. Homogeneity and subsequent exploratory moderator analyses were assessed using Q, T2 and I2. Data sources Medline, EMBASE, CINAHL, SportDiscus and Web of Science to April 2019. Eligibility criteria for selected studies Randomised control trials of behaviour change interventions in men (≥18 years) where physical activity was an outcome and data were from men-only studies or disaggregated by sex. Results Twenty-six articles described 24 eligible studies. The overall mean intervention effect on men’s physical activity was 0.35 (SE=0.05; 95% CI 0.26 to 0.45;

The Near-Infrared and Optical Spectra of Methane Dwarfs and Brown Dwarfs

We identify the pressure--broadened red wings of the saturated potassium resonance lines at 7700 \AA as the source of anomalous absorption seen in the near-infrared spectra of Gliese 229B and, by extension, of methane dwarfs in general. This conclusion is supported by the recent work of Tsuji {\it et al.} 1999, though unlike them we find that dust need not be invoked to explain the spectra of methane dwarfs shortward of 1 micron. We find that a combination of enhanced alkali abundances due to rainout and a more realistic non-Lorentzian theory of resonant line shapes may be all that is needed to properly account for these spectra from 0.5 to 1.0 microns. The WFPC2 $I$ measurement of Gliese 229B is also consistent with this theory. Furthermore, a combination of the blue wings of this K I resonance doublet, the red wings of the Na D lines at 5890 \AA, and, perhaps, the Li I line at 6708 \AA can explain in a natural way the observed WFPC2 $R$ band flux of Gliese 229B. Hence, we conclude that the neutral alkali metals play a central role in the near-infrared and optical spectra of methane dwarfs and that their lines have the potential to provide crucial diagnostics of brown dwarfs. We speculate on the systematics of the near-infrared and optical spectra of methane dwarfs, for a given mass and composition, that stems from the progressive burial with decreasing \teff of the alkali metal atoms to larger pressures and depths.Comment: Revised and accepted to Ap.J. volume 531, March 1, 2000, also available at http://jupiter.as.arizona.edu/~burrows/papers/BMS.p

Comparison of Machine Learning Algorithms for Predictive Modeling of Beef Attributes Using Rapid Evaporative Ionization Mass Spectrometry (REIMS) Data

Ambient mass spectrometry is an analytical approach that enables ionization of molecules under open-air conditions with no sample preparation and very fast sampling times. Rapid evaporative ionization mass spectrometry (REIMS) is a relatively new type of ambient mass spectrometry that has demonstrated applications in both human health and food science. Here, we present an evaluation of REIMS as a tool to generate molecular scale information as an objective measure for the assessment of beef quality attributes. Eight different machine learning algorithms were compared to generate predictive models using REIMS data to classify beef quality attributes based on the United States Department of Agriculture (USDA) quality grade, production background, breed type and muscle tenderness. The results revealed that the optimal machine learning algorithm, as assessed by predictive accuracy, was different depending on the classification problem, suggesting that a “one size fits all” approach to developing predictive models from REIMS data is not appropriate. The highest performing models for each classification achieved prediction accuracies between 81.5–99%, indicating the potential of the approach to complement current methods for classifying quality attributes in beef

Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107367/1/acel12194.pd

A classification model for distinguishing copy number variants from cancer-related alterations

<p>Abstract</p> <p>Background</p> <p>Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in comparative genomic hybridization (CGH) analyses of tumors. In order to identify important cancer genes CNAs and CNVs must be distinguished. Although the Database of Genomic Variants (DGV) contains a list of all known CNVs, there is no standard methodology to use the database effectively.</p> <p>Results</p> <p>We develop a prediction model that distinguishes CNVs from CNAs based on the information contained in the DGV and several other variables, including segment's length, height, closeness to a telomere or centromere and occurrence in other patients. The models are fitted on data from glioblastoma and their corresponding normal samples that were collected as part of The Cancer Genome Atlas project and hybridized to Agilent 244 K arrays.</p> <p>Conclusions</p> <p>Using the DGV alone CNVs in the test set can be correctly identified with about 85% accuracy if the outliers are removed before segmentation and with 72% accuracy if the outliers are included, and additional variables improve the prediction by about 2-3% and 12%, respectively. Final models applied to data from ovarian tumors have about 90% accuracy with all the variables and 86% accuracy with the DGV alone.</p

Rhodopsin F45L Allele Does Not Cause Autosomal Dominant Retinitis Pigmentosa in a Large Caucasian Family

Purpose: To ascertain the potential pathogenicity of a retinitis pigmentosa (RP)-causing RHO F45L allele in a family affected by congenital achromatopsia (ACHM). Methods: Case series/observational study that included two patients with ACHM and 24 extended family members. Molecular genetic analysis was performed to identify RHO F45L carrier status in the family and a control population. An adaptive optics scanning light ophthalmoscope (AOSLO) was used to image the photoreceptor mosaic and assess rod and cone structure. Spectral domain optical coherence tomography (SD-OCT) was used to examine retinal lamination. Comprehensive clinical testing included acuity, color vision, and dilated fundus examination. Electroretinography was used to assess rod and cone function. Results: Five carriers of the RHO F45L allele alone (24-80 years) and three carriers in combination with a heterozygous CNGA3 mutant allele (10-64 years) were all free of the classic symptoms and signs of RP. In heterozygous carriers of both mutations, SD-OCT showed normal retinal thickness and intact outer retinal layers; rod and cone densities were within normal limits on AOSLO. The phenotype in two individuals affected with ACHM and harboring the RHO F45L allele was indistinguishable from that previously reported for ACHM. Conclusions: The RHO F45L allele is not pathogenic in this large family; hence, the two ACHM patients would unlikely develop RP in the future. Translational Relevance: The combined approach of comprehensive molecular analysis of individual genomes and noninvasive cellular resolution retinal imaging enhances the current repertoire of clinical diagnostic tools, giving a substantial impetus to personalized medicine