13 research outputs found
Multi-perspective evaluation of integrated active cooling systems using fuzzy decision making model
As global median temperatures continue to rise, the demand for active cooling systems (ACs) is increasing. These systems are particularly prevalent in developed countries for maintaining comfort during hot weather. Various ACs technologies are available, and assessing their performance in multi-perspective settings is necessary to determine the best option for intended usage. This requires an evaluation platform for assessment. This paper presents a novel multi-criteria decision-making (MCDM) model based on a new integrated 2-tuple linguistic Pythagorean fuzzy-weighted zero-inconsistency (2 TLP-FWZIC) and modified 2-tuple linguistic Pythagorean fuzzy multi-attributive border approximation area comparison (2TLPF-MABAC). The former is used to determine the importance of assessment criteria, while the latter is employed for selecting the optimal ACs using the obtained weights. The first-level weighting results reveal that performance criteria were predominantly favored for assessment, with âenergy performanceâ acquiring the most significant weight (0.2487) among all performance criteria. In terms of ACs selection results, among the 20 tested and assessed systems, the âgeothermal borehole electricity-based ACsâ obtained the highest score value (0.1296), while the âwindow packaged electricity-based ACsâ had the lowest score (-0.0515). The robustness of the results was confirmed through sensitivity analysis
Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats
The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of immuno-inflammatory mediators and heat shock protein expressions in sodium nitrite induced hypoxia in rat lungs. The results revealed that NaNO2 injection caused a significant decrease in Hb in rats, while serum levels of TNF-α, IL-6 and CRP, VEGF and HSP70 were elevated compared to the control group. Administration of melatonin, quercetin or their combination before NaNO2 injection markedly reduced these parameters. Histopathological examination of the lung tissue supported these biochemical findings. The study suggests that melatonin and/or quercetin are responsible for lung tissue protection in hypoxia by downregulation of immuno-inflammatory mediators and heat shock protein expressions. Pre-treatment of hypoxic animals with a combination of melatonin and quercetin was effective in modulating most of the studied parameters to near-normal levels
Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat
ABSTRACT The aim of this study was to investigate the effective role of silymarin either alone or in a combination with vitamin E and/or curcumin against the toxic impact of carbon tetrachloride (CCl4) induced liver injury The results revealed that administration of silymarin alone or in a combination with vitamin E and/or curcumin for 21 consecutive days, 24 h after CCl4 injection to rats, markedly ameliorated DNA damaged and apoptosis markers in rat livers, proinflammatory markers including tumor necrosis factor- α (TNF- α) and C-reactive protein (CRP ) in rat livers as well as interleukin 6 (IL-6), interferon gamma (IFN-γ) and vascular endothelial growth factor (VEGF) in rat sera. These treatments also could ameliorated the alteration in cytochrome P450 2E1 (CYP2E1) activity in livers of CCl4 intoxicated rats as well as the increase in the serum alanine aminotransferase (ALT) compared with CCl4 intoxicated untreated rats. The present biochemical results are supported by histo-pathological examination. In conclusion, silymarin in a combination with vitamin E and curcumin was the most effective treatment in alleviating CCl4 induced liver damage and this may support the use of this combination as an effective treatment against liver damage induced by toxic agents
Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats
The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of immuno-inflammatory mediators and heat shock protein expressions in sodium nitrite induced hypoxia in rat lungs. The results revealed that NaNO2 injection caused a significant decrease in Hb in rats, while serum levels of TNF-α, IL-6 and CRP, VEGF and HSP70 were elevated compared to the control group. Administration of melatonin, quercetin or their combination before NaNO2 injection markedly reduced these parameters. Histopathological examination of the lung tissue supported these biochemical findings. The study suggests that melatonin and/or quercetin are responsible for lung tissue protection in hypoxia by downregulation of immuno-inflammatory mediators and heat shock protein expressions. Pre-treatment of hypoxic animals with a combination of melatonin and quercetin was effective in modulating most of the studied parameters to near-normal levels
Inborn errors of metabolism detectable by tandem mass spectrometry in Egypt: The first newborn screening pilot study
To estimate the burden of metabolic disorders detectable by tandem mass spectrometry in Egypt, through a pilot expanded newborn screening programme at Cairo University Children's Hospital in 2008, and examining the results of 3,900 clinically at-risk children, investigated at Cairo University Children's Hospital for the same disorders over the past 7 years using the same technology.status: publishe
Lysosomal Storage Disorders in Egyptian Children
To describe the spectrum, relative prevalence and molecular background of lysosomal storage disorders in Egypt.status: publishe