Star-Forming Galaxies at z~2 and the Formation of the Metal-Rich Globular Cluster Population

We examine whether the super star-forming clumps (R~1-3 kpc; M~10^8-10^9.5 Msun) now known to be a key component of star-forming galaxies at z~2 could be the formation sites of the locally observed old globular cluster population. We find that the stellar populations of these super star-forming clumps are excellent matches to those of local metal-rich globular clusters. Moreover, this globular cluster population is known to be associated with the bulges / thick disks of galaxies, and we show that its spatial distribution and kinematics are consistent with the current understanding of the assembly of bulges and thick disks from super star-forming clumps at high redshift. Finally, with the assumption that star formation in these clumps proceeds as a scaled-up version of local star formation in molecular clouds, this formation scenario reproduces the observed numbers and mass spectra of metal-rich globular clusters. The resulting link between the turbulent and clumpy disks observed in high-redshift galaxies and a local globular cluster population provides a plausible co-evolutionary scenario for several of the major components of a galaxy: the bulge, the thick disk, and one of the globular cluster populations.Comment: Accepted for publication in MNRAS Letters. 5 pages, 2 figure

The first gigayear of bulge star formation in Virgo ellipticals: constraints from their globular cluster systems

Data products from the Advanced Camera for Surveys Virgo Cluster Survey are used to understand the bulge star formation history in early-type galaxies at redshifts z > 2. A new technique is developed whereby observed high-redshift age-metallicity relationships are utilized to constrain the typical formation epochs of metal-rich or "bulge" globular clusters. This analysis supports a model where massive Virgo galaxies underwent an extremely intense mode of bulge globular cluster formation at z ~ 3.5 that was followed by an era of significant bulge growth and little globular cluster production. Intermediate-mass galaxies showed a less-intense period of globular cluster formation at z ~ 2.5 that was synchronized with the bulk of bulge star growth. The transition between the massive and intermediate-mass galaxy star formation modes occurs at a galaxy stellar mass of M_stellar ~ 3 x 10^10 M_sun, the mass where many other galaxy properties are observed to change. Dwarf early-type galaxies in Virgo may have experienced no significant period of bulge globular cluster formation, thus the intense star bursts associated with globular cluster formation may be difficult to directly observe at redshifts z < 4. Though the above conclusions are preliminary because they are based upon uncertain relationships between age and metallicity, the technique employed will yield more stringent constraints as high-redshift galaxy observations and theoretical models improve.Comment: Accepted by MNRAS. 9 pages text. 6 figures

Gammaherpesvirus-Driven Plasma Cell Differentiation Regulates Virus Reactivation from Latently Infected B Lymphocytes

Gammaherpesviruses chronically infect their host and are tightly associated with the development of lymphoproliferative diseases and lymphomas, as well as several other types of cancer. Mechanisms involved in maintaining chronic gammaherpesvirus infections are poorly understood and, in particular, little is known about the mechanisms involved in controlling gammaherpesvirus reactivation from latently infected B cells in vivo. Recent evidence has linked plasma cell differentiation with reactivation of the human gammaherpesviruses EBV and KSHV through induction of the immediate-early viral transcriptional activators by the plasma cell-specific transcription factor XBP-1s. We now extend those findings to document a role for a gammaherpesvirus gene product in regulating plasma cell differentiation and thus virus reactivation. We have previously shown that the murine gammaherpesvirus 68 (MHV68) gene product M2 is dispensable for virus replication in permissive cells, but plays a critical role in virus reactivation from latently infected B cells. Here we show that in mice infected with wild type MHV68, virus infected plasma cells (ca. 8% of virus infected splenocytes at the peak of viral latency) account for the majority of reactivation observed upon explant of splenocytes. In contrast, there is an absence of virus infected plasma cells at the peak of latency in mice infected with a M2 null MHV68. Furthermore, we show that the M2 protein can drive plasma cell differentiation in a B lymphoma cell line in the absence of any other MHV68 gene products. Thus, the role of M2 in MHV68 reactivation can be attributed to its ability to manipulate plasma cell differentiation, providing a novel viral strategy to regulate gammaherpesvirus reactivation from latently infected B cells. We postulate that M2 represents a new class of herpesvirus gene products (reactivation conditioners) that do not directly participate in virus replication, but rather facilitate virus reactivation by manipulating the cellular milieu to provide a reactivation competent environment

Relativistic superfluid models for rotating neutron stars

This article starts by providing an introductory overview of the theoretical mechanics of rotating neutron stars as developped to account for the frequency variations, and particularly the discontinuous glitches, observed in pulsars. The theory suggests, and the observations seem to confirm, that an essential role is played by the interaction between the solid crust and inner layers whose superfluid nature allows them to rotate independently. However many significant details remain to be clarified, even in much studied cases such as the Crab and Vela. The second part of this article is more technical, concentrating on just one of the many physical aspects that needs further development, namely the provision of a satisfactorily relativistic (local but not microscopic) treatment of the effects of the neutron superfluidity that is involved.Comment: 42 pages LateX. Contribution to Physics of Neutron Star Interiors, ed. D. Blasche, N.K. Glendenning, A. Sedrakian (ECT workshop, Trento, June 2000