Dynamical Computation on Coefficients of Electroweak Chiral Lagrangian from One-doublet and Topcolor-assisted Technicolor Models

Based on previous studies deriving the chiral Lagrangian for pseudo scalar mesons from the first principle of QCD, we derive the electroweak chiral Lagrangian and build up a formulation for computing its coefficients from one-doublet technicolor model and a schematic topcolor-assisted technicolor model. We find that the coefficients of the electroweak chiral Lagrangian for the topcolor-assisted technicolor model are divided into three parts: direct TC2 interaction part, TC1 and TC2 induced effective Z' particle contribution part, and ordinary quarks contribution part. The first two parts are computed in this paper and we show that the direct TC2 interaction part is the same as that in the one-doublet technicolor model, while effective Z' contributions are at least proportional to the p^2 order parameter \beta_1 in the electroweak chiral Lagrangian and typical features of topcolor-assisted technicolor model are that it only allows positive T and U parameters and the T parameter varies in the range 0\sim 1/(25\alpha), the upper bound of T parameter will decrease as long as Z' mass become large. The S parameter can be either positive or negative depending on whether the Z' mass is large or small. The Z' mass is also bounded above and the upper bound depend on value of T parameter. We obtain the values for all the coefficients of the electroweak chiral Lagrangian up to order of p^4.Comment: 52 pages, 15 figure

Electroweak Chiral Lagrangian for a Hypercharge-universal Topcolor Model

Electroweak chiral Lagrangian for a hypercharge-universal topcolor model is investigated. We find that the assignments of universal hypercharge improve the results obtained previously from K.Lane's prototype natural TC2 model by allowing a larger Z' mass resulting in a very small T parameter and the S parameter is still around the order of +1Comment: 12 pages, 7 figure

Identification of neprilysin as a potential target of arteannuin using computational drug repositioning

The discovery of arteannuin (qinghaosu) in the 20th Century was a major advance for medicine. Besides functioning as a malaria therapy, arteannuin is a pharmacological agent in a range of other diseases, but its mechanism of action remains obscure. In this study, the reverse docking server PharmMapper was used to identify potential targets of arteannuin. The results were checked using the chemical-protein interactome servers DRAR-CPI and DDI-CPI, and verified by AutoDock Vina. The results showed that neprilysin (also known as CD10), a common acute lymphoblastic leukaemia antigen, was the top disease-related target of arteannuin. The chemical-protein interactome and docking results agreed with those of PharmMapper, further implicating neprilysin as a potential target. Although experimental verification is required, this study provides guidance for future pharmacological investigations into novel clinical applications for arteannuin

Electroweak Chiral Lagrangian for W′W' Boson

The complete list of electroweak chiral Lagrangian for W', Z' and a neutral light higgs with symmetry $SU(2)_1\otimes SU(2)_2\otimes U(1)$ is provided. The bosonic part is accurate up to order of $p^4$, the matter part involving various fermions representation arrangements includes dimension three Yukawa type and dimension four gauge type operators. The universal mixings and masses of gauge boson and fermion are given. Constraints from mass differences for $K^0-\bar{K}^0$, $B_d^0-\bar{B}_{d}^0$, $B_s^0-\bar{B}_{s}^0$ systems and indirect CP violation parameter $|\epsilon_K|$ for $K$ mesons are evaluated.Comment: 40 pages, 8figure

CCL2: An important cytokine in normal and pathological pregnancies: A review

C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an integral chemotactic factor which recruits macrophages for the immune response. Together with its receptors (e.g., CCR2, ACKR1, and ACKR2), they exert noticeable influences on various diseases of different systems. At the maternal-fetal interface, CCL2 is detected to be expressed in trophoblasts, decidual tissue, the myometrium, and others. Meanwhile, existing reports have determined a series of physiological regulators of CCL2, which functions in maintaining normal recruitment of immunocytes, tissue remodeling, and angiogenesis. However, abnormal levels of CCL2 have also been reported to be associated with adverse pregnancy outcomes such as spontaneous abortion, preeclampsia and preterm labor. In this review, we concentrate on CCL2 expression at the maternal-fetal interface, as well as its precise regulatory mechanisms and classic signaling pathways, to reveal the multidimensional aspects of CCL2 in pregnancy