340 research outputs found

    Making choices real: Increasing electoral participation by voting for none

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    While Nevada legislators have consistently changed Nevada\u27s election laws in order to keep up with the advance of modern society, there are several problems with Nevada\u27s election rules. I intend to discuss reforms that could increase the effectiveness of the none of these candidates law in Nevada. First, I will assess the need for a binding none of these candidates law since the 1970\u27s. I will track patterns of electoral participation so that I can assess the impact of Nevada\u27s electoral laws on the voters of our state. Next, I will define the problems with Nevada\u27s electoral structure and address the theoretical reasons that make a binding version of none of these candidates necessary. I will conclude by addressing different ways to get a binding version of the none of these candidates law adopted in Nevada and throughout the United States

    A Study on NGO Services for Children in Mumbai, India

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    The present research was conducted to study NGOs services for children in Mumbai through a child rights perspective. The study was exploratory in nature and aimed to assess the implementation of child rights by the NGOs. 35 NGOs working for children in the city of Mumbai comprised the sample and were studied using a questionnaire and rating scale as tools. Findings revealed that education (74 percent) and health (54 percent) were the most common concerns of the organizations. Only 17 percent of the NGOs considered child rights to be a concern. The NGOs implemented the right to participation better than any other right. The right to survival was, however, grossly neglected. It was concluded that there are several gaps and areas of lack in the services offered to children. There is also an urgent need to spread awareness amongst the NGO workers themselves to make child rights a part of organizational mandates

    Characterization of Orc6 function following pre-replicative complex assembly in Saccharomyces cerevisiae

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    Pre-replicative complex (pre-RC) components the origin recognition complex (ORC), Cdc6, and Cdt1, play key roles in the recruitment, and loading of the replicative helicase, the minichromosome maintenance complex (Mcm2-7), onto DNA to license origins for replication. Until recently, the prevailing model for pre-RC assembly predicted that once MCMs are loaded at origins, ORC, Cdc6, and Cdt1 are dispensible for replication. Contrary to this model, previous work has shown that Orc6 is required following origin licensing, for the continued association of the MCM complex in late G1 phase. In this study, a similar role in pre-RC maintenance has been demonstrated for Cdc6, and Cdt1. Chromatin immunoprecipitation (ChIP) analysis has shown that late G1 phase depletion of either Cdc6, or Cdt1 leads to the destabilization of MCMs from origins, although this destabilization is more pronounced for Cdc6 depletion than for Cdt1. Furthermore, the resynthesis of Cdc6 following its depletion, allows for the reassembly of pre-RCs in late G1 phase, and restores competence for DNA replication. In this study, a potential role for Orc6 in mitosis/cytokinesis in budding yeast has also been characterized, as research with both Drosophila and human cell lines has pointed to a role for Orc6 in these processes. Deleting HOF1 and CYK3 (two proteins involved in cytokinesis in budding yeast) leads to a synthetic lethal phenotype, suggesting that the resulting gene products function in redundant cytokinetic pathways. Indeed, Hof1 has been shown to be primarily involved in actin ring contraction, while Cyk3 functions in septum formation, both pathways of which are important for budding yeast cytokinesis. Interestingly, previous work has identified an Orc6-Hof1 interaction in budding yeast. In this study, it has been demonstrated that following Orc6 depletion in a GAL1-ORC6/Δcyk3 strain, fluorescence activated cell sorting (FACS) analysis is consistent with a stronger cytokinetic defect phenotype than observed for Δcyk3 cells. Preliminary cell counts indicate that following Orc6 depletion, a higher percentage of GAL1-ORC6/Δcyk3 cells display misshapen mother bud necks than in an isogenic Δcyk3 strain. Cell synchronization experiments have demonstrated that Orc6 depletion during a G2/M phase arrest, leads to a block in cell cycle progression following release

    Primary Care Heart Failure Education Program to Improve Quality of Life

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    Approved May 2018 by the faculty of UMKC in partial fulfillment of the requirements for the degree of Doctor of Nursing PracticeHeart failure is a public health concern within today’s healthcare system at both the national and local level. As the prevalence of heart failure continues to rise, interventions on improving patient outcomes, reducing mortality, and decreasing the frequent inpatient visits associated with the condition is a necessity. To improve patient outcomes for the heart failure population, a heart failure education program with three participants was conducted on adult heart failure patients at a primary care clinic. The purpose of this evidence-based quality improvement project was to determine if evidence-based education, motivational interviewing, and telephone follow-up interventions improve symptoms, quality of life, and decrease 30-day hospital readmission rates in adult heart failure patients within a primary care setting. Patient symptoms and quality of life were measured with the Kansas City Cardiomyopathy Questionnaire. The results of the heart failure education program concluded that patient symptoms improved by 1.21% and quality of life improved by 19.31%. Heart failure is a major public health concern that is both burdensome to patients and costly to the healthcare system. The evidence indicates that educational interventions are warranted to help improve outcomes and the quality of life for those suffering from heart failure

    What Does it Mean to Design? A Qualitative Investigation of Design Professionals' Experiences

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95041/1/j.2168-9830.2012.tb00048.x.pd

    Navigating Competitive Transfer Pathways: Transfer Student Experiences in Health and IT Majors

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    The health care and information technology (IT) fields demand a more diverse set of qualified graduates who can appropriately fulfill the needs of the varied communities they serve. Currently, community colleges serve as stepping stones for diverse student populations and groups. When it comes to pursuing Health- or IT-related fields, community college students are often drawn to those majors with positive career placements and outcomes. Such majors include nursing, business, engineering, and education. However, at many colleges and universities, these majors are considered limited access, meaning that they have strict academic admissions criteria and accept only a limited number of students each year. This study seeks to understand community college student experiences and perceptions related to health or IT transfer pathway careers and success. We specifically examine Health and IT transfer pathways for students studying at a public community college in the Midwest (MidCC) to a large public research institution in the Midwest (MidU) and the faculty and staff working with these populations of students
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