384 research outputs found
Arago (1810): the first experimental result against the ether
95 years before Special Relativity was born, Arago attempted to detect the
absolute motion of the Earth by measuring the deflection of starlight passing
through a prism fixed to the Earth. The null result of this experiment gave
rise to the Fresnel's hypothesis of an ether partly dragged by a moving
substance. In the context of Einstein's Relativity, the sole frame which is
privileged in Arago's experiment is the proper frame of the prism, and the null
result only says that Snell's law is valid in that frame. We revisit the
history of this premature first evidence against the ether theory and calculate
the Fresnel's dragging coefficient by applying the Huygens' construction in the
frame of the prism. We expose the dissimilar treatment received by the ray and
the wave front as an unavoidable consequence of the classical notions of space
and time.Comment: 16 pages. To appear in European Journal of Physic
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Salt and ionic cocrystalline forms of amides: protonation of carbamazepine in aqueous media
The products of reactions of the pharmaceutical amide carbamazepine (CBZ) with strong acids under aqueous conditions were investigated by both powder and single crystal X-ray diffraction. Despite previous claims to the contrary, it was found that salt forms with CBZ protonated at the amide O atom could be isolated from reactions with both HCl and HBr. These forms include the newly identified hydrate phase [CBZ(H)][Cl]·H O. Reactions with other mineral acids (HI and HBF ) gave ionic cocrystalline (ICC) forms (CBZ· [acridinium][I ]·2.5I and CBZ·[H O ] [BF ] ·H O) as well as the salt form CBZ·[CBZ(H)][BF ]·0.5H O. Reaction 2 4 3 2 5 2 0.25 4 0.25 2 4 2 of CBZ with a series of sulfonic acids also gave salt forms, namely, [CBZ(H)][O SC H ], [CBZ(H)][O SC H (OH)]· 3 6 5 3 6 4 0.5H O, [CBZ(H)] [O SCH CH SO ], and [CBZ(H)][O SC H (OH) (COOH)]·H O. CBZ and protonated CBZ(H) 2 2 3 2 2 3 3 6 3 2 moieties can be differentiated in the solid state both by changes to molecular geometry and by differing packing preference
On the Search For Transits of the Planets Orbiting Gl 876
We report the results of a globally coordinated photometric campaign to
search for transits by the P ~ 30 d and P ~ 60 d outer planets of the 3-planet
system orbiting the nearby M-dwarf Gl 876. These two planets experience strong
mutual perturbations, which necessitate use of a dynamical (four-body) model to
compute transit ephemerides for the system. Our photometric data have been
collected from published archival sources, as well as from our photometric
campaigns that were targeted to specific transit predictions. Our analysis
indicates that transits by planet "c" (P ~ 30 d) do not currently occur, in
concordance with the best-fit i = 50 degree co-planar configuration obtained by
dynamical fits to the most recent radial velocity data for the system. Transits
by planet "b" (P ~ 60 d) are not entirely ruled out by our observations, but
our data indicate that it is very unlikely that they occur. Our experience with
the Gl 876 system suggests that a distributed ground-based network of small
telescopes can be used to search for transits of very low mass M-stars by
terrestrial-sized planets.Comment: currently 17pp w/Figs, 10 figures; to appear in Astrophysical Journal
article December 2006 v653n
The NTI-tss device for the therapy of bruxism, temporomandibular disorders, and headache – Where do we stand? A qualitative systematic review of the literature
<p>Abstract</p> <p>Background</p> <p>The NTI-tss device is an anterior bite stop, which, according to the manufacturer, is indicated for the prevention and treatment of bruxism, temporomandibular disorders (TMDs), tension-type headaches, and migraine. The aim of this systematic review was to appraise the currently available evidence regarding the efficacy and safety of the NTI-tss splint.</p> <p>Methods</p> <p>We performed a systematic search in nine electronic databases and in NTI-tss-associated websites (last update: December 31, 2007). The reference lists of all relevant articles were perused. Five levels of scientific quality were distinguished. Reporting quality of articles about randomized controlled trials (RCTs) was evaluated using the Jadad score. To identify adverse events, we searched in the identified publications and in the MAUDE database.</p> <p>Results</p> <p>Nine of 68 relevant publications reported about the results of five different RCTs. Two RCTs concentrated on electromyographic (EMG) investigations in patients with TMDs and concomitant bruxism (Baad-Hansen et al 2007, Jadad score: 4) or with bruxism alone (Kavaklı 2006, Jadad score: 2); in both studies, compared to an occlusal stabilization splint the NTI-tss device showed significant reduction of EMG activity. Two RCTs focused exclusively on TMD patients; in one trial (Magnusson et al 2004, Jadad score: 3), a stabilization appliance led to greater improvement than an NTI-tss device, while in the other study (Jokstad et al 2005, Jadad score: 5) no difference was found. In one RCT (Shankland 2002, Jadad score: 1), patients with tension-type headache or migraine responded more favorably to the NTI-tss splint than to a bleaching tray. NTI-tss-induced complications related predominantly to single teeth or to the occlusion.</p> <p>Conclusion</p> <p>Evidence from RCTs suggests that the NTI-tss device may be successfully used for the management of bruxism and TMDs. However, to avoid potential unwanted effects, it should be chosen only if certain a patient will be compliant with follow-up appointments. The NTI-tss bite splint may be justified when a reduction of jaw closer muscle activity (e.g., jaw clenching or tooth grinding) is desired, or as an emergency device in patients with acute temporomandibular pain and, possibly, restricted jaw opening.</p
Numerical analysis of a mechanism of electrical conductivity of substance in the middle and lower mantle
Signals for Lorentz Violation in Electrodynamics
An investigation is performed of the Lorentz-violating electrodynamics
extracted from the renormalizable sector of the general Lorentz- and
CPT-violating standard-model extension. Among the unconventional properties of
radiation arising from Lorentz violation is birefringence of the vacuum. Limits
on the dispersion of light produced by galactic and extragalactic objects
provide bounds of 3 x 10^{-16} on certain coefficients for Lorentz violation in
the photon sector. The comparative spectral polarimetry of light from
cosmologically distant sources yields stringent constraints of 2 x 10^{-32}.
All remaining coefficients in the photon sector are measurable in
high-sensitivity tests involving cavity-stabilized oscillators. Experimental
configurations in Earth- and space-based laboratories are considered that
involve optical or microwave cavities and that could be implemented using
existing technology.Comment: 23 pages REVTe
Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation
The Wilms’ tumour suppressor protein WT1 plays a central role in the development of the kidney and also other organs. WT1 can act as a transcription factor with highly context-specific activator and repressor functions. We previously identified Brain Acid Soluble Protein 1 (BASP1) as a transcriptional cosuppressor that can block the transcriptional activation function of WT1. WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restricted to the podocyte cells of the adult kidney. Here, we have analysed the WT1/BASP1 complex in a podocyte precursor cell line that can be induced to differentiate. Chromatin immunoprecipitation revealed that WT1 and BASP1 occupy the promoters of the Bak, c-myc and podocalyxin genes in podocyte precursor cells. During differentiation-dependent upregulation of podocalyxin expression BASP1 occupancy of the podocalyxin promoter is reduced compared to that of WT1. In contrast, the repressive WT1/BASP1 occupancy of the c-myc and Bak promoters is maintained and these genes are downregulated during the differentiation process. We provide evidence that the regulation of BASP1 promoter occupancy involves the sumoylation of BASP1. Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation
Autoregressive modeling of transfer functions in frequency domain to determine complex travel times
The glomerular parietal epithelial cell’s responses are influenced by SM22 alpha levels
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