Mononuclear clusterfullerene single‐molecule magnet containing strained fused‐pentagons stabilized by a nearly linear metal cyanide cluster

Fused‐pentagons results in an increase of local steric strain according to the isolated pentagon rule (IPR), and for all reported non‐IPR clusterfullerenes multiple (two or three) metals are required to stabilize the strained fused‐pentagons, making it difficult to access the single‐atom properties. Herein, we report the syntheses and isolations of novel non‐IPR mononuclear clusterfullerenes MNC@C76 (M=Tb, Y), in which one pair of strained fused‐pentagon is stabilized by a mononuclear cluster. The molecular structures of MNC@C76 (M=Tb, Y) were determined unambiguously by single‐crystal X‐ray diffraction, featuring a non‐IPR C2v(19138)‐C76 cage entrapping a nearly linear MNC cluster, which is remarkably different from the triangular MNC cluster within the reported analogous clusterfullerenes based on IPR‐obeying C82 cages. The TbNC@C76 molecule is found to be a field‐induced single‐molecule magnet (SMM)

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the molecular mechanism that negatively regulates this critical step is poorly understood. Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and deubiquitinate RIG-I. Overexpression of USP21 inhibited RNA virus–induced RIG-I polyubiquitination and RIG-I–mediated interferon (IFN) signaling, whereas deletion of USP21 resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN-α/β production, and antiviral responses in MEFs in response to RNA virus infection. USP21 also restricted antiviral responses in peritoneal macrophages (PMs) and bone marrow–derived dendritic cells (BMDCs). USP21-deficient mice spontaneously developed splenomegaly and were more resistant to VSV infection with elevated production of IFNs. Chimeric mice with USP21-deficient hematopoietic cells developed virus-induced splenomegaly and were more resistant to VSV infection. Functional comparison of three deubiquitinases (USP21, A20, and CYLD) demonstrated that USP21 acts as a bona fide RIG-I deubiquitinase to down-regulate antiviral response independent of the A20 ubiquitin-editing complex. Our studies identify a previously unrecognized role for USP21 in the negative regulation of antiviral response through deubiquitinating RIG-I

Rare Metal Mat. Eng.

Highly electro-conductive nano-sized zinc oxide powders were prepared by calcining the precursor synthesized from ZnSO4 center dot 7H(2)O, GaCl3 and NH4HCO3 by the co-precipitation method. The obtained zinc oxide powders were characterized by SEM, TEM, XRD, XPS and BET techniques, and the influence of Ga3+ doping on the electrical conductivity of zinc oxide was investigated. It was found that the volume resistivity of the zinc oxide decreases to 2.0 Omega(.)cm when the Ga3+ doping content is 2.2 mol%, much lower than the conventional zinc oxide powders. This material can be effectively used as electro-conductive fillers in ceramics, fibers, dopes, rubbers and other fields.Highly electro-conductive nano-sized zinc oxide powders were prepared by calcining the precursor synthesized from ZnSO4 center dot 7H(2)O, GaCl3 and NH4HCO3 by the co-precipitation method. The obtained zinc oxide powders were characterized by SEM, TEM, XRD, XPS and BET techniques, and the influence of Ga3+ doping on the electrical conductivity of zinc oxide was investigated. It was found that the volume resistivity of the zinc oxide decreases to 2.0 Omega(.)cm when the Ga3+ doping content is 2.2 mol%, much lower than the conventional zinc oxide powders. This material can be effectively used as electro-conductive fillers in ceramics, fibers, dopes, rubbers and other fields

Comparisons make faces more attractive: An ERP study

Abstract Facial attractiveness judgment largely depends on the characteristics of the facial structure and the personality of the observer. However, little is known about the influence of contextual variations on facial attractiveness. In this electroencephalogram study, participants judged the attractiveness of faces presented individually or in pairs with either a higher‐attractive face (HAF) or lower‐attractive face (LAF). The attractiveness judgment rating of the target face was significantly higher when presented in pairs with HAFs or LAFs than when presented individually and was accompanied by a larger late positive complex. These results suggest that contextual faces enhance the attractiveness judgment of target faces. Microstate analyses revealed that the global field power (GFP) of state 3 was significantly correlated with the attractiveness judgment in the HAF condition whereas the GFP of state 2 was significantly correlated with the attractiveness judgment in the LAF condition. Interestingly, the GFP of state 2 mediated the relationship between narcissism and facial attractiveness judgment in the context of LAFs. Source location analyses showed that states 3 and 2 activated the superior and middle frontal gyrus, which are involved in emotion processing. Our findings suggest that facial attractiveness can be enhanced by contextual comparison with other faces, subject to personality of the observer

Low Expression of CAPON in Glioma Contributes to Cell Proliferation via the Akt Signaling Pathway

CAPON is an adapter protein for nitric oxide synthase 1 (NOS1). CAPON has two isoforms in the human brain: CAPON-L (long form of CAPON) and CAPON-S (short form of CAPON). Recent studies have indicated the involvement of CAPON in tumorigenesis beyond its classical role in NOS1 activity regulation. In this study, we found that the protein levels of CAPON-S, but not than CAPON-L, were significantly decreased in glioma tissues. Therefore, we established lentivirus-mediated stable cell lines with CAPON-S overexpression or down-regulation, and investigated the role of CAPON-S in the proliferation of glioma cells by using CCK8, EdU, and flow cytometry assays. Overexpression of CAPON-S reduced the cell variability and the percentage of EdU-positive cells, and arrested the cells in the G1 phase in glioma cells. Silencing of CAPON by short-hairpin RNA showed the opposite effects. Furthermore, an intracellular signaling array revealed that overexpression of CAPON-S resulted in a remarkable reduction in the phosphorylation of Akt and S6 ribosomal protein in glioma cells, which was further confirmed by Western blot. These findings suggest that CAPON may function as a tumor suppressor in human brain glioma and that the inactivation of the Akt signaling pathway caused by CAPON-S overexpression may provide insight into the underlying mechanism of CAPON in glioma cell proliferation

The main characteristics of different cluster groups of Wangmo <i>C</i>. <i>mollissima</i>.

The main characteristics of different cluster groups of Wangmo C. mollissima.</p

Statistical results of fruit quality traits for each superior Wangmo <i>C</i>. <i>mollissima</i> plant.

Statistical results of fruit quality traits for each superior Wangmo C. mollissima plant.</p

Cluster analysis of 32 superior Wangmo <i>C</i>. <i>mollissima</i> plants.

Cluster analysis of 32 superior Wangmo C. mollissima plants.</p

Thirty-two principal component scores and comprehensive scores of superior plants.

Thirty-two principal component scores and comprehensive scores of superior plants.</p

Component loading matrix of the traits.

In this study, the fruit phenotype and quality of 32 superior Wangmo Castanea mollissima plants (designated GM1 to GM32) were examined to identify the trait characteristics of different cluster groups and germplasms with excellent comprehensive performance. The goal was to provide a theoretical basis and research foundation for collecting high-quality germplasm resources and breeding superior cultivars of Wangmo C. mollissima. Ten fruit phenotypic traits and 13 quality traits were measured and analyzed in these 32 superior Wangmo C. mollissima plants. Cluster analysis and principal component analysis (PCA) were used to perform a comprehensive evaluation. Extremely significant positive correlations (PPPPC. mollissima germplasm resources.</div