2,907 research outputs found
Reservoir of plasmid-encoded beta-lactamases in commensal aerobic faecal bacteria in Britain and South Africa
Z-Vortex Percolation in the Electroweak Crossover Region
We study the statistical properties of Z-vortices and Nambu monopoles in the
3D SU(2) Higgs model for a Higgs mass M_H \approx 100 GeV near and above the
crossover temperature, where these defects are thermally excited. Although
there is no phase transition at that strong selfcoupling, we observe that the
Z-vortices exhibit the percolation transition that has been found recently to
accompany the first order thermal transition that exists at smaller Higgs mass.
Above the crossover temperature percolating networks of Z-vortex lines are
ubiquitous, whereas vortices form a dilute gas of closed vortex loops and
(Nambu) monopolium states on the low-temperature side of the crossover. The
percolation temperature turns out to be roughly independent of the lattice
spacing. We find that the Higgs modulus is smaller (the gauge action is larger)
inside the vortices, compared to the bulk average. This correlation becomes
very strong on the low-temperature side. The percolation transition is a
prerequisite of some string mediated baryon number generation scenarios.Comment: 16 pages, LaTeX, 12 figures, epsf.sty needed; final version to appear
in Phys. Lett.
Heavy-light decay constants from clover heavy quark action in QCD with two flavors of dynamical quarks
We present results on an analysis of the decay constants f_B and f_Bs with
two flavours of sea quark. The calculation has been carried out on 3 different
bare gauge couplings and 4 sea quark masses at each gauge coupling, with
m_pi/m_rho ranging from 0.8 to 0.6. We employ the Fermilab formalism to perform
calculations with heavy quarks whose mass is in the range of the b-quark. A
detailed comparison with a quenched calculation using the same action is made
to elucidate the effects due to the sea quarks.Comment: Contribution to Lattice 99 (Heavy Quarks). Latex file, uses
espcrc2.sty and epsf.sty. 3 pages, 3 encapsulated postscript figure
The Deformation of an Elastic Substrate by a Three-Phase Contact Line
Young's classic analysis of the equilibrium of a three-phase contact line
ignores the out-of-plane component of the liquid-vapor surface tension. While
it has long been appreciated that this unresolved force must be balanced by
elastic deformation of the solid substrate, a definitive analysis has remained
elusive because conventional idealizations of the substrate imply a divergence
of stress at the contact line. While a number of theories of have been
presented to cut off the divergence, none of them have provided reasonable
agreement with experimental data. We measure surface and bulk deformation of a
thin elastic film near a three-phase contact line using fluorescence confocal
microscopy. The out-of-plane deformation is well fit by a linear elastic theory
incorporating an out-of-plane restoring force due to the surface tension of the
gel. This theory predicts that the deformation profile near the contact line is
scale-free and independent of the substrate elastic modulus.Comment: 4 pages, 3 figure
SU(3) breaking in hyperon transition vector form factors
We present a calculation of the SU(3)-breaking corrections to the hyperon
transition vector form factors to in heavy baryon chiral
perturbation theory with finite-range regularisation. Both octet and decuplet
degrees of freedom are included. We formulate a chiral expansion at the
kinematic point , which can be conveniently accessed
in lattice QCD. The two unknown low-energy constants at this point are
constrained by lattice QCD simulation results for the
and transition form factors. Hence we determine
lattice-informed values of at the physical point. This work constitutes
progress towards the precise determination of from hyperon
semileptonic decays
A systematic review of modelling approaches in economic evaluations of health interventions for drug and alcohol problems
© 2016 Hoang et al. Background: The overarching goal of health policies is to maximize health and societal benefits. Economic evaluations can play a vital role in assessing whether or not such benefits occur. This paper reviews the application of modelling techniques in economic evaluations of drug and alcohol interventions with regard to (i) modelling paradigms themselves; (ii) perspectives of costs and benefits and (iii) time frame. Methods: Papers that use modelling approaches for economic evaluations of drug and alcohol interventions were identified by carrying out searches of major databases. Results: Thirty eight papers met the inclusion criteria. Overall, the cohort Markov models remain the most popular approach, followed by decision trees, Individual based model and System dynamics model (SD). Most of the papers adopted a long term time frame to reflect the long term costs and benefits of health interventions. However, it was fairly common among the reviewed papers to adopt a narrow perspective that only takes into account costs and benefits borne by the health care sector. Conclusions: This review paper informs policy makers about the availability of modelling techniques that can be used to enhance the quality of economic evaluations for drug and alcohol treatment interventions
Chemo-Sensitive Running Droplet
Chemical control of the spontaneous motion of a reactive oil droplet moving
on a glass substrate under an aqueous phase is reported. Experimental results
show that the self-motion of an oil droplet is confined on an acid-treated
glass surface. The transient behavior of oil-droplet motion is also observed
with a high-speed video camera. A mathematical model that incorporates the
effect of the glass surface charge is built based on the experimental
observation of oil-droplet motion. A numerical simulation of this mathematical
model reproduced the essential features concerning confinement within a certain
chemical territory of oil-droplet motion, and also its transient behavior. Our
results may shed light on physical aspects of reactive spreading and a
chemotaxis in living things.Comment: 17 pages, 10 figure
The political and scientific challenges in evaluating compulsory drug treatment centers in Southeast Asia
BACKGROUND: In Vietnam, like many countries in Southeast Asia, the commonly used approach of center-based compulsory drug treatment (CCT) has been criticized on human rights ground. Meanwhile, community-based voluntary methadone maintenance treatment (MMT) has been implemented for nearly a decade with promising results. Reform-minded leaders have been seeking empirical evidence of the costs and effectiveness associated with these two main treatment modalities. Conducting evaluations of these treatments, especially where randomization is not ethical, presents challenges. The aim of this paper is to discuss political challenges and methodological issues when conducting cost-effectiveness studies within the context of a non-democratic Southeast Asian country. METHODS: A retrospective analysis of the political and scientific challenges that were experienced in the study design, sample size determination, government approval and ethics approvals, participant recruitment, data collection, and determination of sources, and quantification of cost and effectiveness data was undertaken. As a consequence of the non-randomized design, analysis of patient characteristics for both treatment types was undertaken to identify the magnitude of baseline group differences. Concordance between self-reported heroin use and urine drug testing was undertaken to determine the reliability of self-report data in a politically challenging environment. RESULTS: We demonstrate that conducting research around compulsory treatment in a non-democratic society is feasible, yet it is politically challenging and requires navigation between science and politics. We also demonstrate that engagement with the government decision makers in the research conception, implementation, and dissemination of the results increases the likelihood of research evidence being considered for change in a contentious drug policy area. CONCLUSIONS: Local empirical evidence on the comparative cost-effectiveness of CCT and MMT in a Southeast Asian setting is critical to consideration of more holistic, humane, and effective drug-dependence treatment approaches, but the garnering of such evidence is very challenging.Thu Vuong, Nhu Nguyen , Giang Le, Marian Shanahan, Robert Ali and Alison Ritte
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