Association of postmenopausal bleeding with endometrial cancer

Background: Uterine cancer, also clinically referred to as endometrial cancer, stands out as the most prevalent cancer within the reproductive system of women. Notably, approximately 80% of women experiencing postmenopausal bleeding (PMB) with an endometrial thickness of ≥4 mm exhibit localized pathological lesions in the uterine cavity. This study aimed to assess the association of PMB with endometrial cancer. Methods: This prospective study was conducted at the department of obstetrics and gynecology, delta medical college and hospital, Dhaka, Bangladesh from July 2018 to June 2019. The study comprised 1000 patients selected through purposive sampling, adhering to specific inclusion and exclusion criteria. Microsoft office tools were employed for data processing and analysis. The analytical approach employed was descriptive in nature. Results: The study revealed that the highest percentage of patients (20.20%) exhibited abnormal endometrial hyperplasia, followed by carcinoma cervix (19.2%) and endometrial cancer (16.7%). Additionally, a significant portion of the participants, constituting 40.30%, had co-existing hypertension, while 38.1% had diabetes mellitus, and 34.0% had dyslipidemia. Notably, 65.9% of patients diagnosed with endometrial carcinoma displayed an endometrial thickness exceeding 4 mm. Conclusions: PMB is not statistically significant for endometrial cancer, but prompt evaluation is essential to exclude malignancy. Transvaginal ultrasonography (TVUS) is a reasonable first-line approach, and invasive sampling is recommended when the endometrial thickness exceeds 4 mm

Relationship Between Parental Rejection and Personality

Background: Parental rejection plays an important role in individual's life at different stages of their development. Some types of personality are the major predictors of mental illness and individuals' maladjustment. Objective: The purpose of the present study was to explore the possible relationship between parental rejection and personality of adults in the context of Bangladesh. Methods: A total 100 adults (39 male and 61 female) participated in this study. Their age range was 18 to 60 years. They were selected from Department of Psychiatry, Bangabandhu Sheikh Mujib Medical University, University of Dhaka and some residential areas of Dhaka city by purposive sampling. The instruments used in this study were a Demographic questionnaire, validated Bangla version of Eysenck Personality Questionnaire (EPQ), validated Bangla version of Adult version of Parental Acceptance-Rejection Questionnaire for Father (Adult PARQ: Father) and Adult version of Parental Acceptance-Rejection Questionnaire for Mother (Adult PARQ: Mother). Results: From this study, we found that paternal rejection is positively correlated with psychoticism but negatively correlated with extraversion at the 0.05 levels of significance. The result showed that there was no significant correlation between paternal rejection and neuroticism. Results also showed that maternal rejection is positively correlated with psychoticism and neuroticism at the 0.01 level of significance but negatively correlated with extraversion (at the 0.05 levels). Conclusion: These results suggest that there is an association between parental rejections and individual's personality. Key word: Parental rejection; Personality; Psychoticism; Neuroticism; Extraversion. DOI: 10.3329/bsmmuj.v2i2.4759 BSMMU J 2009; 2(2):61-6

Patients with Acute Limb Ischemia Might Benefit from Endovascular Therapy—A 17-Year Retrospective Single-Center Series of 985 Patients

Acute lower limb ischemia (ALI) is a common vascular emergency, requiring urgent revascularization by open or endovascular means. The aim of this retrospective study was to evaluate patient demographics, treatment and periprocedural variables affecting the outcome in ALI patients in a consecutive cohort in a tertiary referral center. Primary outcome events (POE) were 30-day (safety) and 180-day (efficacy) combined mortality and major amputation rates, respectively. Secondary outcomes were perioperative medical and surgical leg-related complications and the 5-year combined mortality and major amputation rate. Statistical analysis used descriptive and uni- and multivariable Cox regression analysis. In 985 patients (71 ± 9 years, 56% men) from 2004 to 2020, the 30-day and 180-day combined mortality and major amputation rates were 15% and 27%. Upon multivariable analysis, older age (30 d: aHR 1.17; 180 d: 1.27) and advanced Rutherford ischemia stage significantly worsened the safety and efficacy POE (30 d: TASC IIa aHR 3.29, TASC IIb aHR 3.93, TASC III aHR 7.79; 180 d: TASC IIa aHR 1.97, TASC IIb aHR 2.43, TASC III aHR 4.2), while endovascular treatment was associated with significant improved POE after 30 days (aHR 0.35) and 180 days (aHR 0.39), respectively. Looking at five consecutive patient quintiles, a significant increase in endovascular procedures especially in the last quintile could be observed (17.5% to 39.5%, p < 0.001). Simultaneously, the re-occlusion rate as well as the number of patients with any previous revascularization increased. In conclusion, despite a slightly increasing early re-occlusion rate, endovascular treatment might, if possible, be favorable in ALI treatment

Ongoing efforts to improve the management of patients with diabetes in Bangladesh and the implications

Background: Prevalence rates of patients with diabetes are growing across countries, and Bangladesh is no exception. Associated costs are also increasing, driven by costs associated with the complications of diabetes including hypoglycaemia. Long-acting insulin analogues were developed to reduce hypoglycaemia as well as improve patient comfort and adherence. However, they have been appreciably more expensive reducing their affordability and use. Biosimilars offer a way forward. Consequently, there is a need to document current prescribing and dispensing rates for long-acting insulin analogues across Bangladesh, including current prices and differences, as a result of affordability and other issues. Methods: Mixed method approach including surveying prescribing practices in hospitals coupled with dispensing practices and prices among community pharmacies and drug stores across Bangladesh. This method was adopted since public hospitals only dispense insulins such as soluble insulins free-of-charge until funds run out and all long-acting insulin analogues have to be purchased from community stores. Results: There has been growing prescribing and dispensing of long-acting insulins in Bangladesh in recent years, accounting for over 80% of all insulins dispensed in a minority of stores. This has been helped by growing prescribing and dispensing of biosimilar insulin glargine at lower costs that the originator, with this trend likely to continue with envisaged growth in the number of patients. Consequently, Bangladesh can serve as an exemplar to other low- and middle-income countries struggling to fund long-acting insulins for their patients. Conclusions: It was encouraging to see continued growth in the prescribing and dispensing of long-acting insulin analogues in Bangladesh via the increasing availability of biosimilars. This is likely to continue benefitting all key stakeholder groups

Chronotopic manifestations and narrative discourse : a comparative study of the works of Naguib Mahfouz and R. K. Narayan

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Symptom experience and quality of patients with breast cancer receiving chemotherapy in Bangladesh

Thesis (M.N.S., Nursing Science)--Prince of Songkla University, 201

Synthesis of some dihydropyrans by utilizing crotonoyl cyanides as heterodienes in a very mild condition

377-381The reaction of crotonoyl cyanide 1 and its bromo derivative 2 with trimethylene 3 affords the dihydropyrans 6 and 7, respectively. Similarly the compound 1 on reaction with acrolein dimethyl acetal 4 and acrolein diethyl acetal 5 gave the isomeric products 8a/8b and 9a/9b, respectively; the cis-isomer being the predominant one. On the other hand the bromo derivative 2 on treatment with the compound 5 yields only the cis-isomer 10. BF3.Et2O catalysed epimerisation of 11a gives the other epimer 11b in a mild condition with reasonable yield

A computational modeling on transient heat and fluid flow through a curved duct of large aspect ratio with centrifugal instability

AbstractDue to remarkable applications of the curved ducts in engineering fields, scientists have paid much attention to invent new characteristics of curved-duct flow in mechanical systems. In the ongoing study, a computational modeling of fluid flow and energy distribution through a curved rectangular duct of large aspect ratio is presented. Governing equations are enumerated by using a spectral-based numerical technique together with the function expansion and collocation method. The main purpose of the paper is to analyze the effect of centrifugal force in the flow transition as well as heat transfer in the fluid. The investigations are performed for the aspect ratio, Ar = 4; the curvature ratio, $$\delta = 0.5$$ δ = 0.5 ; the Grashof number, $${\text{Gr}} = 1000$$ Gr = 1000 ; and varying the Dean number, $$0 < {\text{Dn}} \le 1000.$$ 0 < Dn ≤ 1000 . It is found that various types of flow regimes including steady-state and irregular oscillations occur as Dn is increased. To well understand the characteristics of the flow phase spaces and power spectrum of the solutions are performed. Next, pattern variations of axial and secondary flow velocity with isotherms are illustrated for different Dn's. It is revealed that the flow velocity and the isotherms are significantly influenced by the duct curvature and the aspect ratio. Convective heat transfer and temperature gradients are calculated which explores that the fluids are diversified due to centrifugal instability, and as a consequence the overall heat transfer is enhanced significantly in the curved duct

THE EFFECT OF GARLIC ON CHOLESTEROL INDUCED HYPERLIPIDAEMIA IN RABBITS

An experimental biochemical study was made on rabbits to demonstrate the possible role of aqueous extract of garlic as an antilipidaemic agent in the prevention of hyperlipidaemia. Untreated rabbits on atherogenic diet showed worse lipidaemic status than the normal control ones, as evident in higher serum cholesterol, triglycerides (TG), low-density lipoprotein (LDL) and lower high-density lipoprotein (HDL) level. On the otherhand the rabbits on atherogenic diet treated with aqueous extract of garlic showed significantly better lipidaemic status. It is suggested that aqueous extract of garlic is an important determinant of serum lipid level, which is an antilipidaemic agent against the pathogenesis of atherosclerosis. Ibrahim Med. Coll. J. 2007; 1(1): 16-2