Naphthidines as redox indicators in titrations with vanadate

Naphthidine, naphthidinedisulphonic acid, 3,3'-dimethylnaphthidine and 3,3'-di-methylnaphthidinedisulphonic acid have been studied as redox indicators in titrations with vanadate. Sharp colour changes are obtained at the equivalence points in titrations of 0.05-0.01 N solutions of iron(II), hydroquinone, molybdenum(V) and uranium(IV) under appropriate conditions of acidity with oxalic or phosphoric acid as indicator catalyst. The transition potentials are reported. © 1978

Prochlorperazine Maleate as a New Redox Indicator In Vanadametry

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EVALUATION OF GENOTOXICITY PROFILE OF JASADA BHASMA (A ZINC-BASED MINERAL FORMULATION) IN SWISS ALBINO MICE

  Objective: Genotoxicity is regarded as one of the potential risk factors for causing pathological diseases. It was confirmed that many chemicals have the mutagenic activity which leads to cancer. A compound which interacts with genetic material DNA and shows adverse effects by altering its structure or function is referred to as genotoxic.Methods: The present study involved 40 Swiss albino mice weighing between 25 and 30 g body weights categorized into four different groups. Group-I (normal control) received 0.5% carboxymethyl cellulose as vehicle. Group-II (toxicant control) received 40 mg/kg/body weight cyclophosphamide on the 28th day. Group-III and IV received test drug JB 15.6 mg/kg and 78 mg/kg, respectively, for 28 consecutive days. Blood samples were collected and processed for evaluating by comet assay. The animals were sacrificed and collected the bone marrow from both the femur for chromosomal aberration and micronuclei assay.Results: JB administered at two different dose levels did not show any significant changes in the comet assay parameters, no micronucleus was found and did not produce any chromosomal aberrations both numerically and structurally when compared to positive test control group.Conclusion: The genotoxicity evaluation of JB did not show any chromosomal aberrations and presence of micronucleus. Thus, the safety data will refine therapeutic utility of JB encouraging their rationale use and translate into greater and broader utilization of JB

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans

Aims: To investigate the effect of kisspeptin on glucose-stimulated insulin secretion and appetite in humans. Materials and methods: In 15 healthy men (age: 25.2 ± 1.1 years; BMI: 22.3 ± 0.5 kg m−2), we compared the effects of 1 nmol kg−1 h−1 kisspeptin versus vehicle administration on glucose-stimulated insulin secretion, metabolites, gut hormones, appetite and food intake. In addition, we assessed the effect of kisspeptin on glucose-stimulated insulin secretion in vitro in human pancreatic islets and a human β-cell line (EndoC-βH1 cells). Results: Kisspeptin administration to healthy men enhanced insulin secretion following an intravenous glucose load, and modulated serum metabolites. In keeping with this, kisspeptin increased glucose-stimulated insulin secretion from human islets and a human pancreatic cell line in vitro. In addition, kisspeptin administration did not alter gut hormones, appetite or food intake in healthy men. Conclusions: Collectively, these data demonstrate for the first time a beneficial role for kisspeptin in insulin secretion in humans in vivo. This has important implications for our understanding of the links between reproduction and metabolism in humans, as well as for the ongoing translational development of kisspeptin-based therapies for reproductive and potentially metabolic conditions

BIRD FORAGING AND ITS ECONOMIC EFFECT IN THE PADDY FIELDS OF BANGALORE (INDIA)

Birds are often serious pests of rice. The small size of this cereal at all stages of its ripening makes it attractive for the small, seed-eating birds. Considerable damage also is inflicted during early stages of growth when germinating seedlings are depredated by grainivores, and several species of aquatic birds trample the fields in search of food. The migratory blackbirds (Agelaius species and others) eat various grains across the U.S.A. and Mexico, while huge numbers of red-billed weaver bird (Quelea quelea) account for grain losses up to 20% in several rice-growing African countries (Efferson, 1952). Although rice is the staple food for the majority of India, information available on bird damage to paddy is inadequate. Spotted munia (Hamid Ali et aI., 1976; Saha and Mukherjee, 1978; Verghese and Chakravarthy, 1981) and baya (Mathew, 1976; Hamid Ali et aI., 1976) are the recognized pests of rice. A host of insectivorous birds prey upon the abundant insect pests of rice. Studies on ecology of rice field birds and their foraging patterns will aid in formulating the best possible measures to prevent damage. Hence, in this preliminary study, data on the density and diversity of birds visiting a paddy field, their spatial and temporal distribution, feeding behavior, and foraging strategy were collected

Not Available

Technical Bulletin on "Distribution of Rodents in Indian Agriculture"Technical Bulletin on "Distribution of Rodents in Indian Agriculture"Not Availabl

Potentiation of anticoagulant toxicity to Rattus rattus by two non-steriod anti-inflammatory drugs

In view of resistance reported to have developed towards second generation anticoagulants and the problem of bait shyness and neophobia when acute rodenticides are used, it becomes imperative that methods be evolved to overcome these problems. Attempts to potentiate anticoagulants for effective rodent control is a new concept with very few studies. Experiments using two non-steroid ant-inflammatory drugs, namely ibuprofen and phenylbutazone at 80 mg/kg and 50 mg/kg body weight respectively to potentiate the action of two second generation anticoagulants, brodifacoum and bromadiolone, yielded positive results for Rattus rattus. The drugs reduced the lethal dose required for 100% mortality as well as days to death. Field trials confirmed laboratory findings

3,3′-Dimethylnaphthidinedisulphonic acid as a selective and sensitive reagent for the spectrophotometric determination of vanadium(V) and its application to vanadium-bearing minerals and alloys

3,3′-Dimethylnaphthidinedisulphonic acid is proposed as a selective and sensitive reagent for the spectrophotometric determination of vanadium(V). It forms a violet coloured species with vanadium(V) in 8–13 M orthophosphoric acid medium. A 2-fold molar excess of reagent is necessary for the full development of the colour. The violet species exhibits an absorption maximum at 555 nm with a molar absorptivity of 1.94 × 104 l mol–1 cm–1. Sandell's sensitivity is 2.6 ng cm–2. Beer's law is obeyed for the range 0.08–3.5 p.p.m. of vanadium(V) with an optimum concentration range of 0.1–3.1 p.p.m. The proposed method offers the advantages of simplicity, high sensitivity, good selectivity and the opportunity to carry out the determination at room temperature without the need for an extraction step. The method has been used successfully for the determination of vanadium in ilmenite and vanadium steels

Naphthidines & o-Dianisidine as Redox Indicators in Titrations with Cerium(IV) Sulphate

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