Solar extreme ultraviolet variability of the quiet Sun

The last solar minimum has been unusually quiet compared to the previous minima (since space-based radiometric measurements are available). The Sun's magnetic flux was substantially lower during this minimum. Some studies also show that the total solar irradiance during the minimum after cycle 23 may have dropped below the values known from the two minima prior to that. For chromospheric and coronal radiation, the situation is less clear-cut. The Sun's 10.7\,cm flux shows a decrease of $\sim4\%$ during the solar minimum in 2008 compared to the previous minimum, but \ion{Ca}{II} K does not. Here we consider additional wavelengths in the extreme ultraviolet (EUV), specifically transitions of \ion{He}{I} at 584.3\,\AA\ and \ion{O}{V} at 629.7\,\AA , of which the CDS spectrometer aboard SOHO has been taking regular scans along the solar central meridian since 1996. We analysed this unique dataset to verify if and how the radiance distribution undergoes measurable variations between cycle minima. To achieve this aim we determined the radiance distribution of quiet areas around the Sun centre. Concentrating on the last two solar minima, we found out that there is very little variation in the radiance distribution of the chromospheric spectral line \ion{He}{I} between these minima. The same analysis shows a modest, although significant, 4\% variation in the radiance distribution of the transition region spectral line \ion{O}{V}. These results are comparable to those obtained by earlier studies employing other spectral features, and they confirm that chromospheric indices display a small variation, whereas in the TR a more significant reduction of the brighter features is visible

Effects of opium dependency on hypothalamic pituitary gonadal axis

The aim of this study was to determine the effect of opium on hypothalamic pituitary gonad function. Fifty-six opium dependent (28 men and 28 women; mean age, 25±5 year) were enrolled for hypothalamic pituitary gonadal axis. The control group considered of 56 non-opium dependent subject (28 men and 28 women; mean age 25±5 year). Decreased libido or impotency was present in 26 of 28 opium dependent men. The serum testosterone level was below 9 nmol L-1 in 24 of 28 men and was significantly lower than that in the control group (p<0.001). The free androgen index was below normal in 16 of 28 men and was significantly lower than that in the control group (p<0.001). The serum LH level was less than 2 U L-1 in 17 of 28 men significantly lower than that in the control group (p<0.001). Serum FSH was normal in both groups. Decreased libido was present in 16 of 28 women opium dependent. Serum LH, estradiol and progesterone levels were lower in opium group. In conclusion, of all opium addicts the large majority of men and all of women developed hypogonadotropic hypogonadism. The results reveal that opium can extract deleterious actions upon male and female hypothalamic pituitary gonadal axis and these findings suggested that further investigations are required to determine the need for endocrine work-up in opium dependent and the important substitutive therapy

Performance Portable Solid Mechanics via Matrix-Free pp-Multigrid

Finite element analysis of solid mechanics is a foundational tool of modern engineering, with low-order finite element methods and assembled sparse matrices representing the industry standard for implicit analysis. We use performance models and numerical experiments to demonstrate that high-order methods greatly reduce the costs to reach engineering tolerances while enabling effective use of GPUs. We demonstrate the reliability, efficiency, and scalability of matrix-free $p$-multigrid methods with algebraic multigrid coarse solvers through large deformation hyperelastic simulations of multiscale structures. We investigate accuracy, cost, and execution time on multi-node CPU and GPU systems for moderate to large models using AMD MI250X (OLCF Crusher), NVIDIA A100 (NERSC Perlmutter), and V100 (LLNL Lassen and OLCF Summit), resulting in order of magnitude efficiency improvements over a broad range of model properties and scales. We discuss efficient matrix-free representation of Jacobians and demonstrate how automatic differentiation enables rapid development of nonlinear material models without impacting debuggability and workflows targeting GPUs

Response to dietary supplementation of L-glutamine and L-glutamate in broiler chickens reared at different stocking densities under the hot, humid tropical conditions

A study was conducted to determine whether supplementing AminoGut (a commercial dietary supplement containing a mixture of l-glutamine and l-glutamic acid) to broiler chickens stocked at 2 different densities affected performance, physiological stress responses, foot pad dermatitis incidence, and intestinal morphology and microflora. A randomized design in a factorial arrangement with 4 diets [basal diet, basal diet + 0.5% AminoGut from d 1 to 21, basal diet + 0.5% AminoGut from d 1 to 42, and basal diet + virginiamycin (0.02%) for d 1 to 42] and 2 stocking densities [0.100 m2/bird (23 birds/pen; LD) or 0.067 m2/bird (35 birds/pen; HD)]. Results showed that villi length and crypt depth were not changed by different dietary treatments. However, birds in the HD group had smaller villi (P = 0.03) compared with those of the LD group. Regardless of diet, HD consistently increased the serum concentrations of ceruloplasmin, α-1 acid glycoprotein, ovotransferin, and corticosterone (P = 0.0007), and elevated heterophil to lymphocyte ratio (0.0005). Neither AminoGut supplementation nor stocking density affected cecal microflora counts. In conclusion, under the conditions of this study, dietary supplementation of AminoGut, irrespective of stocking density, had no beneficial effect on growth performance, intestinal morphology, and physiological adaptive responses of broiler chickens raised under hot and humid tropical conditions. However, AminoGut supplementation from d 1 to 42 was beneficial in reducing mortality rate. Also, the increased serum concentrations of a wide range of acute phase proteins together with elevated corticosterone and heterophil to lymphocyte ratio suggested that high stocking density induced an acute phase response either indirectly as a result of increased incidence of inflammatory diseases such as foot pad dermatitis or possibly as a direct physiological response to the stress of high stocking density

Serosurvey of human antibodies recognizing Aedes aegypti D7 salivary proteins in Colombia

Citation: Londono-Renteria, B. L., Shakeri, H., Rozo-Lopez, P., Conway, M. J., Duggan, N., Jaberi-Douraki, M., & Colpitts, T. M. (2018). Serosurvey of Human Antibodies Recognizing Aedes aegypti D7 Salivary Proteins in Colombia. Frontiers in Public Health, 6. https://doi.org/10.3389/fpubh.2018.00111Background: Dengue is one of the most geographically significant mosquito-borne viral diseases transmitted by Aedes mosquitoes. During blood feeding, the mosquito deposits salivary proteins that induce antibody responses. These can be related to the intensity of exposure to bites. Some mosquito salivary proteins, such as D7 proteins, are known as potent allergens. The antibody response to D7 proteins can be used as a marker to evaluate the risk of exposure and disease transmission, and provide critical information for understanding the dynamics of vector-host interactions. Methods: The study was conducted at the Los Patios Hospital, Cucuta, Norte de Santander, Colombia. A total of 63 participants were enrolled in the study. Participants were categorized into three disease status groups, age groups, and socioeconomic strata. The level of IgG antibodies against D7 Aedes proteins was determined by ELISA. We used a statistical approach to determine if there is an association between antibody levels and factors such as age, living conditions, and dengue virus infection. Results: We found that IgG antibodies against D7 proteins were higher in non-DENV infected individuals in comparison to DENV-infected participants. Also, age factor showed a significant positive correlation with IgG antibodies against D7 proteins, and the living conditions (socioeconomic stratification), in people ages 20 years or older, are a statistically significant factor in the variability of IgG antibodies against D7 proteins. Conclusions: This pilot study represents the first approximation to elucidate any correlation between the antibody response against mosquito D7 salivary proteins and its correlation with age, living conditions and dengue virus infection in a dengue endemic area