Sustainable Urban Regeneration of Blighted Neighborhoods: The Case of Al Ghanim Neighborhood, Doha, Qatar

At a time when urban expansion and regeneration are being prioritized, many cities are undergoing significant widespread urban decay. Planning issues, such as the regeneration of historical areas and the redevelopment of blighted neighborhoods, have prompted a complex agenda to be put in place for urban planning practice. The most significant district is the city's core. It is a crucial indicator of the city's success because it contains the Central Business District (CBD) and housing. However, due to poor governmental attention, many city cores are experiencing new development, subsequently overwhelming the old neighborhoods. Consequently, old areas are witnessing urban disfigurement and fast deterioration in their physical and visual characteristics. This research utilizes urban regeneration to address the city's core challenges to help achieve sustainable development. To test the sustainability framework, the researchers used Qatar's local case study of the Old Ghanim neighborhood, one of Doha's oldest districts. As a result of the original population's relocation to suburban developments, the district has deteriorated, lacking street activity and increasing indigent public space. The researchers examined the literature on urban regeneration, conducted site visits and observations, reviewed and described case study limitations, and identified factors that contribute to the creation of a sustainable neighborhood, based on urban qualities such as integrated networks and walkable streets, open and green public spaces, and the regeneration of the old urban fabric. As a result, they intended to address a theoretical and practical gap in current local knowledge, and they additionally intended to provide a helpful tool for urban regeneration specialists. The researchers proposed a conceptual framework for rejuvenating neglected neighborhoods and ideas for ensuring urban cohesion, which is critical for improving the lives of individuals in these areas.This publication was made possible by the NPRP grant (NPRP 12S-0304-190230) from the Qatar National Research Fund (a member of Qatar Foundation). The statements made herein are solely the responsibility of the authors.Scopu

Genome-Wide Detection of SNP Markers Associated with Four Physiological Traits in Groundnut (Arachis hypogaea L.) Mini Core Collection

In order to integrate genomics in breeding and development of drought-tolerant groundnut genotypes, identification of genomic regions/genetic markers for drought surrogate traits is essential. We used 3249 diversity array technology sequencing (DArTSeq) markers for a genetic analysis of 125 ICRISAT groundnut mini core collection evaluated in 2015 and 2017 for genome-wide marker-trait association for some physiological traits and to determine the magnitude of linkage disequilibrium (LD). Marker-trait association (MTA) analysis, probability values, and percent variation modelled by the markers were calculated using the GAPIT package via the KDCompute interface. The LD analysis showed that about 36% of loci pairs were in significant LD (p 0.2) and 3.14% of the pairs were in complete LD. The MTAs studies revealed 20 significant MTAs (p < 0.001) with 11 markers. Four MTAs were identified for leaf area index, 13 for canopy temperature, one for chlorophyll content and two for normalized difference vegetation index. The markers explained 20.8% to 6.6% of the phenotypic variation observed. Most of the MTAs identified on the A subgenome were also identified on the respective homeologous chromosome on the B subgenome. This could be due to a common ancestor of the A and B genome which explains the linkage detected between markers lying on different chromosomes. The markers identified in this study can serve as useful genomic resources to initiate marker-assisted selection and trait introgression of groundnut for drought tolerance after further validation

Drought tolerance mechanisms for responses to pre and post flowering drought stress of groundnut in a dryland ecology

Understanding the mechanisms of groundnut tolerance to pre and post flowering drought stress is important for improving its yield and phenological development in the drylands. The mechanisms of drought tolerance are known to be under variable genetic control. The aim of this study was to investigate the mechanism of drought tolerance of various groundnut genotypes to pre and post flowering drought stress. Screen house trials were undertaken between March and June 2014. Three moisture management treatments were imposed on 10 groundnut cultivars. Three cultivars (Ex-Oakar, Samnut 23 and Samnut 24) are known to have some drought tolerance characteristics; two cultivars (Samnut 21 and Samnut 22) do not tolerate drought, while the drought response ofthe remaining five cultivars (Samnut 25, Samnut 26, Sabiya, Kwankwaso and Yar Oigir) is not known. The water managements were: Field Capacity throughout the period of experimentation (FCT), Imposition of PreFlowering Moisture Stress (PrFS) and Imposition of Post Flowering Stress (PoFS). Stomatal conductance and relative water content (RWC) were recorded at 10, 15, 20, 25, 30, 35,40 and 45 days after emergence. Total dry matter samples (shoots and pods) were collected at 15 and 25 days after emergence, R5 and R7. From these samples, shoot and pod growth rates were calculated. Two ofthe drought tolerant cultivars were found to tolerate only pre-flowering drought and only Ex-Oakar tolerate both pre and post flowering drought stress. Among the two susceptible cultivars, Samnut 22 was found to tolerate post-flowering stress, but was susceptible to pre flowering stress. Samnut 26 and Kwankwaso tolerated both pre and post flowering stress, while Sabiya and Yar Oigir were susceptible to both stresses. Most of the cultivars adopted the mechanism of conserving water by reducing transpiration to maintain high RWC. Only Samnut 24 showed the mechanism of improving assimilate partitioning to the pods at grain filling phase. The knowledge gathered could be used for breeding groundnut that will be suited to the drylands in order to escape periods of intermittent drought

Standard set of health outcome measures for older persons

Background: The International Consortium for Health Outcomes Measurement (ICHOM) was founded in 2012 to propose consensus-based measurement tools and documentation for different conditions and populations.This article describes how the ICHOM Older Person Working Group followed a consensus-driven modified Delphi technique to develop multiple global outcome measures in older persons. The standard set of outcome measures developed by this group will support the ability of healthcare systems to improve their care pathways and quality of care. An additional benefit will be the opportunity to compare variations in outcomes which encourages and supports learning between different health care systems that drives quality improvement. These outcome measures were not developed for use in research. They are aimed at non researchers in healthcare provision and those who pay for these services. Methods: A modified Delphi technique utilising a value based healthcare framework was applied by an international panel to arrive at consensus decisions.To inform the panel meetings, information was sought from literature reviews, longitudinal ageing surveys and a focus group. Results: The outcome measures developed and recommended were participation in decision making, autonomy and control, mood and emotional health, loneliness and isolation, pain, activities of daily living, frailty, time spent in hospital, overall survival, carer burden, polypharmacy, falls and place of death mapped to a three tier value based healthcare framework. Conclusions: The first global health standard set of outcome measures in older persons has been developed to enable health care systems improve the quality of care provided to older persons

Perceptions of consent, permission structures and approaches to the community: a rapid ethical assessment performed in North West Cameroon

BACKGROUND Understanding local contextual factors is important when conducting international collaborative studies in low-income country settings. Rapid ethical assessment (a brief qualitative intervention designed to map the ethical terrain of a research setting prior to recruitment of participants), has been used in a range of research-naïve settings. We used rapid ethical assessment to explore ethical issues and challenges associated with approaching communities and gaining informed consent in North West Cameroon. METHODS This qualitative study was carried out in two health districts in the North West Region of Cameroon between February and April 2012. Eleven focus group discussions (with a total of 107 participants) were carried out among adult community members, while 72 in-depth interviews included health workers, non-government organisation staff and local community leaders. Data were collected in English and pidgin, translated where necessary into English, transcribed and coded following themes. RESULTS Many community members had some understanding of informed consent, probably through exposure to agricultural research in the past. Participants described a centralised permission-giving structure in their communities, though there was evidence of some subversion of these structures by the educated young and by women. Several acceptable routes for approaching the communities were outlined, all including the health centre and the Fon (traditional leader). The importance of time spent in sensitizing the community and explaining information was stressed. CONCLUSIONS Respondents held relatively sophisticated understanding of consent and were able to outline the structures of permission-giving in the community. Although the structures are unique to these communities, the role of certain trusted groups is common to several other communities in Kenya and Ethiopia explored using similar techniques. The information gained through Rapid Ethical Assessment will form an important guide for future studies in North West Cameroon

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria.

Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emergence and spread of the SARS-CoV-2 B.1.1.318 and B.1.525 (Eta) variants of interest in Nigeria and the wider Africa region. By integrating travel data and phylogeographic reconstructions, we find that these two variants that arose during the second wave in Nigeria emerged from within Africa, with the B.1.525 from Nigeria, and then spread to other parts of the world. Data from this study show how regional connectivity of Nigeria drove the spread of these variants of interest to surrounding countries and those connected by air-traffic. Our findings demonstrate the power of genomic analysis when combined with mobility and epidemiological data to identify the drivers of transmission, as bidirectional transmission within and between African nations are grossly underestimated as seen in our import risk index estimates