67 research outputs found
The Groebke-Blackburn-Bienayme Reaction
Imidazo[1,2a]pyridine is a wellâknown scaffold in many marketed drugs, such as Zolpidem, Minodronic acid, Miroprofen and DSâ1 and it also serves as a broadly applied pharmacophore in drug discovery. The scaffold revoked a wave of interest when Groebke, Blackburn and BienaymĂ© reported independently a new three component reaction resulting in compounds with the imidazo[1,2âa]âheterocycles as a core structure. During the course of two decades the Groebke Blackburn BienaymĂ© (GBBâ3CR) reaction has emerged as a very important multicomponent reaction (MCR), resulting in over a hundred patents and a great number of publications in various fields of interest. Now two compounds derived from GBBâ3CR chemistry received FDA approval. To celebrate the first 20 years of GBBâchemistry , we present an overview of the chemistry of the GBBâ3CR, including an analysis of each of the three starting material classes, solvents and catalysts. Additionally, a list of patents and their applications and a more inâdepth summary of the biological targets that were addressed, including structural biology analysis, is given
ChemInform Abstract: Cytotoxic Activity Assessment, QSAR and Docking Study of Novel Bis-Carboxamide Derivatives of 4-Pyrones Synthesized by Ugi Four-Component Reaction.
ChemInform Abstract: Synthesis of Pyrone Carbaldehydes, Pyrone Sulfonium Ylides and Related Epoxides.
ChemInform Abstract: Synthesis of 2,6-Bis(1H-indole-6-yl)-4H-pyran-4-ones via Leimgruber-Batcho Indole Synthesis.
ChemInform Abstract: Stereoselective Synthesis of ÎČ-Amino Ketones Possessing ÎČ-[(2H-Pyran-2-one)-3-yl]-ÎČ-chlorovinyl Moiety via Three-Component Direct Mannich Reaction, Catalyzed with ZrOCl2·8H2O.
ChemInform Abstract: Boric Acid as a Mild and Efficient Catalyst for One-Pot Synthesis of 1-Amidoalkyl-2-naphthols under Solvent-Free Conditions.
ChemInform Abstract: Chemistry of Pyrones. Part 1. Synthesis of Triketones and Triketoesters and Related 4H-Pyran-4-ones.
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