194 research outputs found

    Optimum Power Output Control of a Wind Turbine Rotor

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    Š 2016 S. Wijewardana et al. An active and optimum controller is applied to regulate the power output from a wind turbine rotor. The controller is synthesized in two steps. The first step defines the equilibrium operation point and ensures that the desired equilibrium point is stable. The stability of the equilibrium point is guaranteed by a control law that is synthesized by applying the methodology of model predictive control (MPC). The method of controlling the turbine involves pitching the turbine blades. In the second step the blade pitch angle demand is defined. This involves minimizing the mean square error between the actual and desired power coefficient. The actual power coefficient of the wind turbine rotor is evaluated assuming that the blade is capable of stalling, using blade element momentum theory. This ensures that the power output of the rotor can be reduced to any desired value which is generally not possible unless a nonlinear stall model is introduced to evaluate the blade profile coefficients of lift and drag. The relatively simple and systematic nonlinear modelling and MPC controller synthesis approach adopted in this paper clearly highlights the main features on the controller that is capable of regulating the power output of the wind turbine rotor

    User-driven design of decision support systems for polycentric environmental resources management

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    Open and decentralized technologies such as the Internet provide increasing opportunities to create knowledge and deliver computer-based decision support for multiple types of users across scales. However, environmental decision support systems/tools (henceforth EDSS) are often strongly science-driven and assuming single types of decision makers, and hence poorly suited for more decentralized and polycentric decision making contexts. In such contexts, EDSS need to be tailored to meet diverse user requirements to ensure that it provides useful (relevant), usable (intuitive), and exchangeable (institutionally unobstructed) information for decision support for different types of actors. To address these issues, we present a participatory framework for designing EDSS that emphasizes a more complete understanding of the decision making structures and iterative design of the user interface. We illustrate the application of the framework through a case study within the context of water-stressed upstream/downstream communities in Lima, Peru

    Barriers to development and progression of women entrepreneurs in Pakistan

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    This article would help integration of women entrepreneurs into the mainstream economy in Pakistan.In Pakistan, women entrepreneurs do not enjoy the same opportunities as men due to a number of deep-rooted discriminatory socio-cultural values and traditions. Furthermore, these restrictions can be observed within the support mechanisms that exist to assist such fledgling businesswomen. The economic potential of female entrepreneurs is not being realised as they suffer from a lack of access to capital, land, business premises, information technology, training and agency assistance. Inherent attitudes of a patriarchal society, that men are superior to women and that women are best suited to be homemakers, create formidable challenges. Women also receive little encouragement from some male family members, resulting in limited spatial mobility and a dearth of social capital. The research suggests that in order to foster development, multi-agency cooperation is required. The media, educational policy makers and government agencies could combine to provide women with improved access to business development services and facilitate local, regional and national networks

    Impact of hydrodynamic conditions on optimum power generation in dual stage pressure retarded osmosis using spiral-wound membrane

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    The Dual Stage Pressure Retarded Osmosis technique is considered for power generation. The influence of feed flow rates, hydraulic pressure, and pressure drop on mass transfer and solute diffusion in a full-scale membrane model was investigated for the first time to maximize power generation. Dead Sea-seawater, Dead Sea-reverse osmosis brine, reverse osmosis brine-wastewater, and seawater-wastewater salinity gradient resources were investigated for power generation. Results revealed a 71.07% increase in the specific power generation due to the dual-stage pressure retarded osmosis process optimization using Dead Sea-seawater salinity gradient resources. The increase in the specific power generation due to the dual-stage pressure retarded osmosis optimization was 108.8%, 63.18%, and 133.54%, respectively, for Dead Sea-reverse osmosis brine, reverse osmosis brine-wastewater, and seawater-wastewater salinity gradient resources. At optimum operating conditions, using the dual-stage pressure retarded osmosis process as an alternative to the single pressure retarded osmosis process achieved up to a 22% increase in the energy output. Interestingly, the hydraulic pressure at optimum operating conditions was slightly higher than the average osmotic pressure gradients in the dual-stage pressure retarded osmosis process. The study also revealed that power generation in the dual-stage pressure retarded osmosis process operating at constant mass transfer and solute resistivity parameters was overestimated by 2.8%

    Predictors of in-hospital mortality and complications in very elderly patients undergoing emergency surgery

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    INTRODUCTION: With the increasing aging population demographics and life expectancies the number of very elderly patients (age ≥ 80) undergoing emergency surgery is expected to rise. This investigation examines the outcomes in very elderly patients undergoing emergency general surgery, including predictors of in-hospital mortality and morbidity. METHODS: A retrospective study of patients aged 80 and above undergoing emergency surgery between 2008 and 2010 at a tertiary care facility in Canada was conducted. Demographics, comorbidities, surgical indications, and perioperative risk assessment data were collected. Outcomes included length of hospitalization, discharge destination, and in-hospital mortality and morbidity. Multivariable logistic regression was used to identify predictors of in-hospital mortality and complications. RESULTS: Of the 170 patient admissions, the mean age was 84 years and the in-hospital mortality rate was 14.7%. Comorbidities were present in 91% of this older patient population. Over 60% of the patients required further services or alternate level of care on discharge. American Society of Anesthesiologist Physical Status (ASA) Classification (OR 5.30, 95% CI 1.774-15.817, p = 0.003) and the development of an in-hospital complications (OR 2.51, 95% CI 1.210-5.187, p = 0.013) were independent predictors of postoperative mortality. Chronological age or number of comorbidities was not predictive of surgical outcome. CONCLUSIONS: Mortality, complication rates and post-discharge care requirements were high in very elderly patients undergoing emergency general surgery. Advanced age and medical comorbidities alone should not be the limiting factors for surgical referral or treatment. This study illustrates the importance of preventing an in-hospital complication in this very vulnerable population. ASA class is a robust tool which is predictive of mortality in the very elderly population and can be used to guide patient and family counseling in the emergency setting

    Entrepreneurial capital, social values and Islamic traditions: exploring the growth of women-owned enterprises in Pakistan

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    Main ArticleThis study seeks to explore the variables contributing to the growth of women-owned enterprises in the Islamic Republic of Pakistan. Based on a previously established multivariate model, it uses two econometric approaches: first classifying variables into predetermined blocks; and second, using the general to specific approach. Statistical analyses and in-depth interviews confirm that women entrepreneurs’ personal resources and social capital have a significant role in their business growth. Further, it reveals that the moral support of immediate family, independent mobility and being allowed to meet with men play a decisive role in the sales and employment growth of women-owned enterprises in an Islamic country such as Pakistan

    Adherence to Point-of-Use Water Treatment over Short-Term Implementation: Parallel Crossover Trials of Flocculation-Disinfection Sachets in Pakistan and Zambia.

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    The health benefits of point-of-use (POU) water treatment can only be realized through high adherence: correct, consistent, and sustained use. We conducted parallel randomized, longitudinal crossover trials measuring short-term adherence to two single-use flocculant-disinfectant sachets in Pakistan and Zambia. In both trials, adherence declined sharply for both products over the eight week surveillance periods, with overall lower adherence to both products in Zambia. There was no significant difference in adherence between the two products. Estimated median daily production of treated water dropped over the crossover period from 2.5 to 1.4 L person-1 day-1 (46% decline) in Pakistan and from 1.4 to 1.1 L person-1 day-1 (21% decline) in Zambia. The percentage of surveillance points with detectable total chlorine in household drinking water declined from 70% to 49% in Pakistan and rose marginally from 28% to 30% in Zambia. The relatively low and decreasing adherence observed in this study suggests that these products would have provided little protection from waterborne disease risk in these settings. Our findings underscore the challenge of achieving high adherence to POU water treatment, even under conditions of short-term adoption with intensive follow-up

    The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation towards the kidney lineage

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    During embryonic development, the mesoderm undergoes patterning into diverse lineages including axial, paraxial, and lateral plate mesoderm (LPM). Within the LPM, the so-called intermediate mesoderm (IM) forms kidney and urogenital tract progenitor cells, while the remaining LPM forms cardiovascular, hematopoietic, mesothelial, and additional progenitor cells. The signals that regulate these early lineage decisions are incompletely understood. Here, we found that the centrosomal protein 83 (CEP83), a centriolar component necessary for primary cilia formation and mutated in pediatric kidney disease, influences the differentiation of human induced pluripotent stem cells (hiPSCs) towards intermediate mesoderm. We induced inactivating deletions of (CEP83) in hiPSCs and applied a 7 day in vitro protocol of intermediate mesoderm kidney progenitor differentiation, based on timed application of WNT and FGF agonists. We characterized induced mesodermal cell populations using single cell and bulk transcriptomics and tested their ability to form kidney structures in subsequent organoid culture. While hiPSCs with homozygous (CEP83) inactivation were normal regarding morphology and transcriptome, their induced differentiation into IM progenitor cells was perturbed. Mesodermal cells induced after 7 days of monolayer culture of (CEP83)-deficient hiPCS exhibited absent or elongated primary cilia, displayed decreased expression of critical IM genes ((PAX8), (EYA1), (HOXB7)), and an aberrant induction of LPM markers (e. g. (FOXF1), (FOXF2), (FENDRR), (HAND1) ,(HAND2)). Upon subsequent organoid culture, wildtype cells differentiated to form kidney tubules and glomerular-like structures, whereas (CEP83)-deficient cells failed to generate kidney cell types, instead upregulating cardiomyocyte, vascular, and more general LPM progenitor markers. Our data suggest that (CEP83) regulates the balance of intermediate mesoderm and lateral plate mesoderm formation from human pluripotent stem cells, identifying a potential link between centriolar or ciliary function and mesodermal lineage induction
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