Phytopharmacological review of Bunium persicum (Boiss)B. fedtsch.

Bunium persicum(BOISS)B.Fedtsch belonging to family Apiaceae is native to the region of the limited zones of the West Asia, Kherman and grows to the areas of North Khorasan and Kheraman, East of the Zagros range to Bandar Abbaas and south area of the Albroz range in Iran. It is also found in North western parts of Himalayas. Bunium persicum is found growing naturally in sub-alpine and alpine habitats of North Western Himalayas. It is a perennial herb, dwarf 30cm to tall 80cm and its flowers are small, white in color. Keywords: Bunium persicum, Apiaceae, North-Western Himalayas, Perrenial Her

Phytomedicines as potent alternative Anti-microbial naturopathic treatment in Chronic Communicable diseases: A Review

Communicable Diseases are caused by various opportunistic pathogenic micro-organisms that pose a serious health threat to the health of human beings. The contagious diseases are spread by various pathogenic micro-organisms like bacteria, viruses, fungi, bacteria or Protozoa through various mediums like air, blood, feces or through other blood fluids etc. Malaria, Respiratory disorders, fever, Measles, athletes foot, rabies are some common examples of these diseases. Allopathic management of these diseases by synthetic drugs pose serious health threats like multi-drug resistance. Phytomedicines are considered the safest alternative sources of treatment to overcome the multi-drug resistance as the important phytoconstituents present in phytomedicines like alkaloids, flavonoids, phenols are known since time immemorial for their alleviation in chronic diseases like Cancer, Diabetes etc

Use of web resources by research scholars in select institutes of J&K and Delhi.

Web resources are fast becoming mainstay for sharing of intellectual output throughout the globe with little limitations and numerous benefits that surpasses all mediums of communication of scholarly content known to world so far. The study has made a strenuous effort to know the awareness, use and acceptability of web resources among research community of select institutes in Jammu & Kashmir and Delhi. The present study is spread over five chapters and three appendices discussing various facets of the theme.Digital copy of ThesisUniversity of Kashmi

Sublingual immunotherapy to house dust mite as an immunological intervention in refractory atopic dermatitis

Sublingual immunotherapy (SLIT) with house dust mite (HDM) preparation has been shown to reduce disease severity in patientswith atopic dermatitis (AD). A 5-year-old girl with severe Atopic Dermatitis refractive to all possible pharmacotherapy was put onSLIT for dust mite and followed up for a period of one year. SLIT to dust mite proved highly effective in reducing the disease severityscore as well as prevention of exacerbations in this patient

HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF POLYGONUM PERSICARIA LINN AND ITS ACTIVE PRINCIPLE ON CARBON TETRACHLORIDE INDUCED TOXICITY IN RATS

The present study was carried out to observe the hepatoprotective effect and antioxidant activity of the aqueous extract of the roots of Polygonum persicaria (PP) and its active principle i.e Tannic Acid (TA) in rats treated with carbon tetrachloride (1.5 ml/kg, i.p.). Twenty albino wistar rats were allotted to five groups (control, CCl4 induced hepatotoxicity and hepatotoxicity with Polygonum persicaria and Tannic acid and one group acts as a standard treated with silymarin 100 mg/kg. Rats were scarified after 14 days. Toxicity was performed using 12 rats. They were randomly divided into three groups (control and treated with 200 mg/kg (B.wt) of Polygonum persicaria & 200 mg/kg (B.wt) of Tannic acid. Extract of PP and TA at the tested doses restored the levels of liver homogenate enzymes (glutathione peroxidase, glutathione-S transferase, superoxide dismutase and catalase enzymes significantly and supported the biochemical observations. This study suggests that Tannic acid has a more liver protective effect in comparison of Polygonum persicaria against carbon tetrachloride- induced hepatotoxicity and possess antioxidant activities and exhibited moderate anticancer activity towards cell viability at higher concentration. Liver injury was confirmed by the histological changes

Molecular typing of HLA-class II alleles reveals an association with autoantibodies and disease subsets of systemic sclerosis in a North Indian (Kashmir) population

Aim of the work: To identify specific human leukocyte antigen (HLA)-Class II (DRB/DQB1/DPB1) alleles associated with systemic sclerosis (SSc) and to explore their relation with SSc autoantibodies, clinical manifestations, and disease subsets. Patients and methods: HLA-class II alleles (DRB1/DRB3/DRB4/DRB5/DQB1) were determined by DNA typing in 80 SSc cases and 60 matched controls and HLA-DPB1 in 40 SSc patients and 30 controls by allele-specific-polymerase chain reaction with sequence-specific primers (PCR-SSP). Results: The mean age of SSc patients was 36.9 ± 9.4 years; 76 females and 4 males (F:M 19:1) and a disease duration of 5.3 ± 3.3 years, they were 43(53.7%) limited and 37(46.2%) diffuse subtypes. SSc was significantly associated with DRB1*11, DRB1*01, DQB1*04, and DQB1*03*03 in a >4-fold manner, whereas DPB1*04 had a >7-fold increased risk compared to controls. There was a strong association between DRB1*11 (p = 0.04), DQB1*03*03 (p = 0.005), and DPB1*13 (p = 0.009) with anti-topoisomerase I (anti-topoI) whereas the frequency of DRB1*01 (p < 0.0001) was increased in patients with anti-centromere (ACA) positive SSc compared those negative (56% vs 25%; p < 0.0001). DRB1*03, DRB1*15, and DQB1*03*01 were SSc protective alleles in patients with positive ACA. Anti-topo I was associated with interstitial lung disease (ILD) (p < 0.01), whereas ACA with pulmonary arterial hypertension (PAH) (p = 0.01) and protection against ILD (p < 0.001). In addition, HLA-DRB1*03, DQB1*03*01and DPB1*03 were more frequent in patients with ILD than in patients without. Conclusion: Associations between specific HLA-class II alleles with certain SSc-specific autoantibodies (anti-topo I and ACA) were identified. Specific HLA associations with clinical and serological subtypes could serve as biomarkers of disease severity and progression in SSc

Biologically active hydroxymoyl chlorides as antifungal agents

740-747Several oximes and oxime ethers have been developed as antimicrobial agents. A series of chlorooximes (hydroximoyl chlorides) have been synthesized and tested for antifungal activity under in-vitro conditions against Candida albicans, Candida parapsilosis, Candida glabrata, Candida krusei, Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. The derived antifungal activity has been compared with the corresponding oximes. The results show that most of the chlorooximes exhibit potent antifungal activity with anti-isomers showing better activity. It is observed that most of the chlorooximes show interesting antifungal activity (MICs < 32 μg/mL) compared to oximes. Compound 3q (2,3-dimethoxy phenyl hydroxymoyl chloride) is the most active compound. This compound is active against all the Candida species (MIC 0.5 μg/mL) as well as filamentous fungi with MIC range of 2-4 μg/mL. This series of compounds are fungicidal in nature as evident from the MFC results