A conceptual model for assessing managerial implications of changes in information technologies (Bilişim teknolojilerindeki değişimlerin yönetsel sonuçlarının değerlendirmesi için kavramsal bir model)

Information Technologies and business should be considered together to get the best results in business life. Therefore their integration and reflections on each other are very important in managing institutional change due to changes in the IT world. Change is a very sensitive concept that must be managed very carefully. In this article, a framework for managing IT based changes by protecting the business leverage and through all levels of hierarchy in the company is proposed

The Mediating Role of Interpersonal Relationships and Self-Differentiation in The Relationship Between Attachment Styles and Social Phobia

The aim of this study was to examine the relationships between social phobia, attachment styles, interpersonal relationships, and self-differentiation and to determine the mediating role of interpersonal relationships and self-differentiation in the relationship between attachment styles and social phobia. A total of 314 people, 197 (62.7%) women, and 117 (37.3%) men, aged between 18 and 70 years (30.60±11.66), were included in the study conducted in Istanbul. They were used as data collection tools Liebowitz Social Phobia Scale, Scale of Dimensions Interpersonal Relationship, Relationship Scales Questionnaire, and Self-Differentiation Scale. Parallel mediation analyzes were performed using Hayes's PROCESS macro plug-in based on the Bootstrap method. According to the results of the correlation analysis, weak and moderately significant relationships were found between the variables. The mediation analysis findings revealed, that approval dependence, trusting others, and emotional reactivity have parallel mediation effects in the relationship between secure attachment and social phobia-anxiety; that approval dependence and trusting others have parallel mediation effects in the relationship between secure attachment and social phobia-avoidance; that trusting others and emotional reactivity have parallel mediation effects in the relationship between dismissing attachment and social phobia-anxiety and avoidance; that approval dependence and trusting others had parallel mediation effect in the relationship between fearful attachment and social phobia-anxiety and avoidance; that approval dependence, trusting others and emotional reactivity had parallel mediation effect in the relationship between obsessive attachment and social phobia-anxiety; and that approval dependence and trusting others had parallel mediation effect in the relationship between preoccupied attachment and social phobia-avoidance. A total of 8 significant models explained between 4% and 19% of the variance. It can be said that the findings of the study can contribute to the determination of the variables mediating the relationship between attachment and social phobia and the development of clinical interventions for these variables

Recipient Site Necrosis After Tumescent Infiltration with Adrenaline in Hair Transplantation

Letter to the editor No abstract available</p

ETAP: Energy-Aware Timing Analysis of Intermittent Programs

Energy harvesting battery-free embedded devices rely only on ambient energy harvesting that enables stand-alone and sustainable IoT applications. These devices execute programs when the harvested ambient energy in their energy reservoir is sufficient to operate and stop execution abruptly (and start charging) otherwise. These intermittent programs have varying timing behavior under different energy conditions, hardware configurations, and program structures. This article presents Energy-aware Timing Analysis of intermittent Programs (ETAP), a probabilistic symbolic execution approach that analyzes the timing and energy behavior of intermittent programs at compile time. ETAP symbolically executes the given program while taking time and energy cost models for ambient energy and dynamic energy consumption into account. We evaluate ETAP by comparing the compile-time analysis results of our benchmark codes and real-world application with the results of their executions on real hardware. Our evaluation shows that ETAP’s prediction error rate is between 0.0076% and 10.8%, and it speeds up the timing analysis by at least two orders of magnitude compared to manual testing.acceptedVersio

The Mediating Role of Emotion Lability and Emotion Regulation in The Relationship Between Social-Emotional Adaptation with Behavior Regulation and Social Skills Among Preschool Children

Self-regulation is defined as an individual's ability to control and regulate their own behavior; this skill, forming the foundation of social adjustment, influences one's ability to interact with their environment and manage relationships. Emotion regulation, on the other hand, involves the ability to manage emotional responses and is believed to establish a critical connection between social adjustment and self-regulation. In this study, the aim is to determine the mediating role of emotion regulation in the relationship between behavioral regulation, social skills, and social-emotional adjustment skills using two different models.The study included a total of 216 children aged 5 and 6. Data were collected using the Socio-Demographic Information Form, Emotion Regulation Scale (ERS), Child Behavior Rating Scale (CBRS), and Marmara Social-Emotional Adaptation Scale (MSEAS). When socio-demographic variables were evaluated in terms of social competence and social-emotional adjustment scores according to gender, significant differences were found in favor of girls. Significant differences were also found in favor of children with working mothers when evaluated based on the mother's employment status. There were moderate significant correlations found between emotion regulation, child behavior assessment, and social-emotional adjustment. According to the mediation analyses, there was a partial mediating effect of emotion variability/negativity and emotion regulation in the relationship between behavior regulation and social-emotional adjustment. Similarly, there was a partial mediating effect of emotion variability/negativity and emotion regulation in the relationship between social competence and social-emotional adjustment. It is thought that the finding that children's emotion regulation and emotion variability/negativity mediate the relationship between social-emotional adjustment, social competence, and behavior regulation will contribute to the literature

A monogenic autoinflammatory disease with fatal vasculitis: deficiency of adenosine deaminase 2

Purpose of review To recap the expanding clinical spectrum, genotype-phenotype associations and treatment options in the light of recently published articles regarding the deficiency of adenosine deaminase 2 (DADA2). Recent findings Whole-exome sequencing enabled novel clinical phenotypes associated withADA2mutations. Since its discovery, the phenotypic spectrum of DADA2 has substantially expanded to cover Diamond-Blackfan anaemia, cytopenia and immunodeficiency syndromes. In addition to elevated TNF alpha levels, increased levels of interferon-stimulated genes were also detected in patients with DADA2. Given the absence of clinical trials until now, no standard treatment strategy exists for DADA2. Currently, anti-TNF alpha agents are the mainstay of treatment, based on the data both from the initial two reports and from subsequent studies. However, it is still unclear how to manage asymptomatic patients withADA2mutation and/or with absent ADA2 activity and what is the optimal duration of anti-TNF therapy. Among a total of 206 DADA2 patients described so far, the overall mortality was found as 8.3%. Biallelic homozygous G47R mutations were mostly associated with a vascular phenotype, whereas patients with homozygous R169Q mutations seem to display a mixed clinical phenotype including vascular, haematological and immunological manifestations. HSCT should be reserved as a curative treatment option for DADA2 patients unresponsive to the anti-TNF therapy, as it carries a significant morbidity

Biologics in juvenile idiopathic arthritis-main advantages and major challenges: A narrative review

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. The disease is divided in different subtypes based on main clinical features and disease course. Emergence of biological agents targeting specific pro-inflammatory cytokines responsible for the disease pathogenesis represents the revolution in the JIA treatment. Discovery and widespread usage of biological agents have led to significant improvement in JIA patients' treatment, with evidently increased functionality and decreased disease sequel. Increased risk of infections remains the main discussion topic for years. Despite the slightly increased frequency of upper respiratory tract infections reported in some studies, the general safety of drugs is acceptable with rare reports of severe adverse effects (SAEs). Tuberculosis (TBC) represents the important threat in regions with increased TBC prevalence. Therefore, routine screening for TBC should not be neglected when prescribing and during the follow-up of biological treatment. Malignancy represents a hypothetical complication that sometimes causes hesitations for physicians and patients in its prescription and usage. On the other hand, current reports from the literature do not support the increased risk for malignancy among JIA patients treated with biological agents. A multidisciplinary approach including a pediatric rheumatologist and an infectious disease specialist is mandatory in the follow-up of JIA patients. Although the efficacy and safety of biological agents have been proven in different studies, there is still a need for long-term, multicentric evaluation providing relevant data

A recently explored aspect of the iceberg named COVID-19: multisystem inflammatory syndrome in children (MIS-C)

Humanity has recently gained a novel foe named coronavirus disease 2019. Although data so far mostly suggest that children are more likely to have a favorable disease course, new concerns have been raised because of recently reported pediatric cases with hyperinflammatory conditions resembling Kawasaki disease, toxic shock syndrome, and macrophage activation syndrome/hemophagocytic lymphohistiocytosis. Because the increasing evidence suggests that this recent hyperinflammatory condition emerged in the coronavirus disease 2019 era is a distinct clinical picture, the Centers for Disease Control and Prevention named this novel disease multisystem inflammatory syndrome in children. Even if this novel disease is rare, it seems to be highly fatal. Therefore, it is urgent to understand the pathogenesis of the disease to be able to establish the appropriate treatment regimes. Concerns regarding the diagnostic process and the management of the disease have been raised even among pediatricians. Therefore, we aimed to clarify this newly occurring enigma based on the current literature and our clinical insights

Pediatric Behcet's Disease

Behcet's Disease (BD) is a systemic vasculitis firstly described as a disorder causing aphthous lesion in oral and genital mucosae and uveitis. The disease has an extremely unique distribution characterized by the highest incidence in communities living along the historical Silk road. Although our understanding of the etiopathogenesis of BD has expanded over time, there are still lots of unidentified points in the underlying mechanisms of the disease. The accepted opinion in the light of the current knowledge is that various identified and/or unidentified infectious and/or environmental triggers can take a role as a trigger in individuals with genetic susceptibility. Although the disease usually develops in young adulthood, it is reported that about 15-20% of all Behcet's patients develop in childhood. Pediatric BD differs from adult BD not only with the age of onset but also in the frequency and distribution of clinical findings, disease severity and outcome. While gastrointestinal system involvement, neurological findings, arthralgia and positive family history are more common in children, genital lesions and vascular lesions are more common in adult patients. In addition, a better disease outcome with lower severity score and activity index has been reported in children. The diagnosis of the disease is made according to clinical findings. It can be challenging to diagnose the disease due to the absence of a specific diagnostic test, and the long time interval from the first finding of the disease to the full-blown disease phenotype in pediatric cases. Therefore, many classification criteria have been proposed so far. The widely accepted ones are proposed by the International Study Group. The new sets of classification criteria which is the only one for pediatric BD were also developed for pediatric cases by the PEDBD group. The primary goal for the treatment is preventing the organ damages by suppressing the ongoing inflammation and forestalling the disease flares. The treatment of the BD can be onerous due to its multisystemic nature and a multidisciplinary approach is essential for the management of the patients. In this review article, the definition, clinical findings, epidemiology, etiopathogenesis, and treatment will be discussed