THE EFFECT OF FRESH GARLIC ON THE LIPID PROFILE AND ATHEROSCLEROSIS DEVELOPMENT IN MALE RATS FED WITH A HIGH GHEE DIET

Objective: Garlic has a protective effect against hyperlipidemia and ghee in diet is considered as a risk factor for hyperlipidemia. We examined the effects of fresh garlic administration on body weight, lipid profiles and plaque formation in the male rats fed with a high ghee diet.Methods: Twenty-four male Wistar rats were randomly divided into 3 groups of 8. The control group consumed an ordinary diet, Group 2 received the 31% ghee pellets (high ghee diet) and group 3 received the 8% garlic+31% ghee pellets. After 9 mo, serum levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and atherosclerotic index (AI) were examined. Changes in body weight, daily food intake and plaque formation also were assayed in this survey.Results: The high ghee diet induced the significant increase (P<0.05) in serum concentrations of TC, TG and HDL-C, and a decrease in LDL-C concentration (group 2). While fresh garlic increased TG (P<0.05) and HDL-C levels and declined TC and LDL-C in treated rats (group 3). Meanwhile, ghee and garlic showed a favorable effect in reducing AI (P<0.05). No histopathological changes were observed in the Aorta of the rats.Conclusion: Evidence obtained from this study indicates that ghee and fresh garlic has potential effects in the prevention and control of hyperlipidemia complications and are beneficial when taken as a dietary supplement.  Â

The Role of Antiepileptic Treatment in the Recurrence Rate of Seizures After First Attack: A Randomized Clinical Trial

How to Cite This Article: Assarzadegan F, Tabesh H, Hesami O, Derakhshanfar H, Beladi Moghadam N, Shoghli A, Beale A.D, Hosseini-Zijoud S.M. The Role of Antiepileptic Treatment in the Recurrence Rate of Seizures After First Attack: A Randomized Clinical Trial. Iran JChild Neurol. Spring 2015; 9(2):46-52.AbstractObjectiveEpilepsy is a serious, potentially life-shortening brain disorder that occurs in patients of all ages and races. A total of 2–4% of people have experienced seizures at least once in their lifetime. Although treatment usually begins after a seizure, it is an important question whether the first cases of seizure do need to be treated by antiepileptic drugs. In this manner, we compare the recurrence rates of epilepsy in first seizure patients treated with sodium valproic acid as an antiepileptic drug versus a placebo.Material & MethodsIn a randomized clinical trial study, 101 first seizure patients were randomly divided into two groups: one group was treated with antiepileptic drugs (sodium valproate 200mg, three times a day) and the other group was given a placebo.The recurrence rate of seizures was evaluated and compared between the groups after 6 months of follow up.ResultsEight recurrence cases were detected. All recurrence cases came from the placebo group, with four patients suffering an additional seizure after four months and between 4-6 month follow up. A comparison of recurrence rate detected a statistically significant difference between the drug group and placebo group.ConclusionOur data shows that the recurrences occurred only in the placebo group with the difference between the recurrence rates in the placebo versus drug-treated was significant. Our results suggest that drug therapy for people after their first seizure attack might reduce the probability of seizure recurrence

Comparison of oral dydrogesterone with vaginal progesteronefor luteal support in IUI cycles: a randomized clinical trial

Background: The aim of this study, we have compared the advantages of oral dydrogestrone with vaginal progesterone (cyclogest) for luteal support in intrauterine insemination (IUI) cycles. Progesterone supplementation is the first line treatment when luteal phase deficiency (LPD) can reasonably be assumed. Objective: This study was conduct to compare the effect of oral dydrogestrone with vaginal Cyclogest on luteal phase support in the IUI cycles. Materials and Methods: This prospective, randomized, double blind study was performed in a local infertility center from May 2013 to May 2014. It consisted of 150 infertile women younger than35years old undergoing ovarian stimulation for IUI cycles. They underwent ovarian stimulation with oral dydrogesterone (20 mg) as group A and vaginal cyclogest (400 mg) as group B in preparation for the IUI cycles. Clinical pregnancy and abortion rates, mid luteal progesterone (7daysafter IUI) and patient satisfaction were compared between two groups. Results: The mean serum progesterone levels was significantly higher in group A in comparison with group B (p=0.001). Pregnancy rates in group A was not statistically different in comparison with group B (p =0.58). Abortion rate in two groups was not statistically different (p =0.056) although rate of abortion was higher in group B in comparison with A group. Satisfaction rates were significantly higher in group A compared to group B (p<0.001). Conclusion: We concluded that oral dydrogestrone is effective as vaginal progesterone for luteal-phase support in woman undergoing IUI cycles. Moreover, the mean serum progesterone levels and satisfaction rates in dydrogestrone group were higher than cyclogest group

Seroepidemiology of toxoplasmosis in pregnant women referring to health centers in the city of Hamadan in 1391

Introduction: Toxoplasmosis is a most common parasitic infection in humans and animals, it has two acute and chronic phases that related to IgM and IgG, respectively. This prevalence is affected by different variables, so determination of the prevalence of serum IgG and IgM antibodies against Toxoplasma in terms of these variables like age, occupation and education level is so important.Material and Methods: This descriptive-analytic cross sectional study was done on 350 pregnant women referred to health - Therapeutic centers of Hamadan city. After obtaining informed consent from volunteers, their serum samples were tested by IgG ELISA and IgM ELISA methods and their associations with age, occupation and education level variables were measured.Results: From total of 350 pregnant women, 105 cases (30%) had anti-Toxoplasma IgG, and 3 cases (2.9%) had anti-Toxoplasma IgM. Antibody titer of IgM with variable age, occupation and education level was not significant, but antibody titer of IgG with these variables was significant.Conclusion: Given the significant association between the disease and age, occupation and education level in pregnant women, it should be provide the necessary training and knowledge about preventiion and avoid of being infected with toxoplasmosis infection

Lipid Peroxidation and Antioxidant Status in Patients with Medullary Thyroid Carcinoma: A Case-Control Study

Submitted by Fabricia Pimenta ([email protected]) on 2017-06-27T20:44:26Z No. of bitstreams: 1 Zicker_etal_2016.pdf: 193598 bytes, checksum: 4469fc2696bc60d0f6e10e1cc34c4c71 (MD5)Approved for entry into archive by Fabricia Pimenta ([email protected]) on 2017-12-22T15:21:42Z (GMT) No. of bitstreams: 1 Zicker_etal_2016.pdf: 193598 bytes, checksum: 4469fc2696bc60d0f6e10e1cc34c4c71 (MD5)Made available in DSpace on 2017-12-22T15:21:42Z (GMT). No. of bitstreams: 1 Zicker_etal_2016.pdf: 193598 bytes, checksum: 4469fc2696bc60d0f6e10e1cc34c4c71 (MD5) Previous issue date: 2016-02Hamadan, Iran.Shahid Beheshti University of Medical Sciences. Faculty of Medicine. Department of Internal Medicine. Tehran, Iran.Hamadan University of Medical Sciences. School of Medicine. Department of Biochemistry. Hamadan, Iran.Shahid Beheshti University of Medical Sciences. Research Institute for Endocrine Sciences. Cellular and Molecular Endocrine Research Center. Tehran, Iran.Hamadan University of Medical Sciences. School of Medicine. Department of Clinical Biochemistry. Department of Biochemistry. Hamadan, Iran.Shahid Beheshti University of Medical Sciences. Faculty of Medicine. Department of Cardiology. Tehran, Iran.Hamadan University of Medical Sciences. School of Public Heath. Research Center for Health Sciences and Department of Epidemiology. Hamadan, Iran.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Hamadan University of Medical Sciences. School of Medicine. Department of Biochemistry. Hamadan, Iran.Oxidative stress or oxidant/antioxidant imbalance has a crucial role in the pathogenesis of some diseases like cancer. Medullary thyroid carcinoma (MTC) originates in the thyroid parafollicular cells and includes 3-4% of the malignant neoplasms that have an effect on this gland. The aetiology of MTC has not been clarified. However, oxidative stress may be one of the factors involved