Üniversiteler süper ligindeki kadın basketbolcuların fiziksel uygunluk profillerinin belirlenerek vücut kompozisyonuyla ilişkilendirilmesi

The object of the present study is to determine physical fitness profiles of female basketball players playing in the universities’ super league and to associate them with the body compositions. 38 volunteer sportswomen 38 (age: 21.06±1.46 years) dealing with basketball were included in the study. Body mass index (BMI) of each subject was calculated by dividing her body weight in kilogram by square of her height in meter. In determination of physical fitness, their body compositions, reaction times and anaerobic performances were assessed. Body fat percentage was calculated by Zorba formula and somatotype features were estimated by using Heath-Carter method. Vertical jumping test was used in anaerobic performance while La Fayette multi-option reaction time scale was employed to determine reaction. It was found that the subjects had endomorphic- ectomorphy (4.2-1.6-3.2) somatotype feature, normal body mass index (BMI) (21.43±1.81), normal body fat percentage (FP) (15.01±2.32), average anaerobic power (AP) (88.30±13.06kgm.s-1;883.04±130.06N.ms-1=watt), relative anaerobic power (RAP) (1.34±.96; 13.46±.9606N.ms-1=watt), average left visual reaction (205.68±31.53), right visual reaction (193.02±24.15), left audio reaction (180.73±24.11), right audio reaction (174.78±21.93). A significant correlation was found between the obtained FP and left visual reaction (r=.464; p<0.01) as well as left visual reaction and endomorph (r=.434; p<0.01) according to the conducted Pearson Multiplications’ Moment while any significant correlation was not seen between BMI and AP (r=.593; p<0.01). A significant correlation between fat-free body mass and AP (r=.895; p<0.01) was found while any significant correlation between mesomorph and AP (r=-.330; p<0.05) was not found. A similar correlation was found between ectomorph and AP (r=-.332; p<0.05).As a result, the findings of the study have indicated that female basketball players’ body mass indexes, fat-free body masses and mesomorphic and ectomorphic features have a determinative role in their anaerobic performances and also, that an association exists between their physical fitness profiles and body compositions.Bu çalışmanın amacı, üniversite süper liginde oynayan kadın basketbolcuların fiziksel uygunluk profillerinin belirlenerek vücut kompozisyonuyla ilişkilendirilmesidir.Çalışmaya basketbol branşıyla uğraşan 38 ( yaş: 21.06±1.46 yıl) gönüllü kadın sporcu katılmıştır. Katılımcıların Vücut kitle indeksi (VKİ) kilogram cinsinden vücut ağırlığının, metre cinsinden boyun karesine bölünmesiyle belirlenirken, Fiziksel uygunluklarının belirlenmesi ise vücut kompozisyonu, reaksiyon zamanı ve anaerobik performansları değerlendirilmiştir. Vücut yağ yüzdesi Zorba formülü ile hesaplanırken, somatotip özellikler Heath-Carter yöntemi kullanılarak hesaplanmıştır. Anaerobik performansta dikey sıçrama testi, reaksiyonu belirlemek içinse La Fayette çok seçenekli reaksiyon zaman ölçeği kullanılmıştır. Bulgularda çalışmaya katılan kadın basketbolcuların, endomorfik - ektomorfi (4.2-1.6-3.2) somatotip özelliğe, normal vücut kitle indeksine(VKİ) (21.43±1.81), normal vücut yağ yüzdesine(YY) (15.01±2.32), ortalama anaerobik güce (AG) (88.30±13.06kgm.s-1;883.04±130.06N.ms-1=watt), relatif anaerobik güce (RAG) (1.34±.96; 13.46±.9606N.ms-1=watt), ortalama sol görsel reaksiyona (205.68±31.53), sağ görsel reaksiyona (193.02±24.15), sol işitsel reaksiyona (180.73±24.11), sağ işitsel reaksiyona (174.78±21.93) sahip oldukları görülmüştür. Yapılan Pearson Çarpımlar Moment Korelâsyonu sonucunda elde edilen YY ile sol görsel reaksiyon (r=.464; p<0.01) ve sol görsel reaksiyon ile endomorfi (r=.434; p<0.01) arasında anlamlı bir ilişki bulunurken, VKİ ile AG (r=.593; p<0.01) arasında da anlamlı bir ilişki bulunmuştur. Yağsız beden kitlesi ile AG (r=.895; p<0.01) arasında anlamlı bir ilişki belirlenirken, mezomorf ile AG (r=-.330; p<0.05) arasında da anlamlı bir ilişki belirlenmiştir. Benzer bir ilişkide ektomorf ile AG (r=-.332; p<0.05) arasında bulunmuştur.Sonuç olarak, çalışmadaki bulgular, kadın basketbolculardaki vücut kitle indeksinin, yağsız beden kitlesinin, mezomorfik ve ektomorfik özelliklerin anaerobik performanslarında belirleyici rol aldığı görülürken, kadın basketbolcuların fiziksel uygunluk profilleriyle vücut kompozisyonları arasında ilişki olduğu belirlenmiştir.&nbsp

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

An Analysis and Evaluation of Game Philosophy and Demographic Characteristics of Women’s Basketball Team Coaches and Players in Turkey and in the US

Bu araştırmada, basketbolun daha iyi seviyeye gelmesi ve çağdaş anlayışlarla sürdürülebilmesi için, Türkiye ve Amerika’daki Elit Bayan Basketbol Tak›mlar›n›n oyuncu ve antrenörlerinin, alt yap›lar› ve tak›m sistemleri incelenmiş ve aradaki ilişkiler tespit edilmeye çalışılmıştır. Çalışmanın sporcu grubunu; Amerika Bayanlar Basketbol Kolej Ligi (NCAA) Divison I`de yer alan 240, Türkiye Deplasmanl› Bayanlar Basketbol 1. Liginde yer alan 128 elit bayan basketbolcu; antrenör grubunu ise yine bu seviyede antrenörlük yapan Amerika’dan 24, Türkiye’den 17, toplam 41 antrenör oluşturmaktadır. Araştırma literatür taraması ve araştırmacı tarafından geliştirilmiş anket yoluyla gerçekleşmiştir. Uygulanan anketler, sporcularda toplam 28, antrenörlerde toplam 36 sorudan oluşmaktadır. Demografik bilgileri, basketbol sporuyla ilgili tutum ve düşünceleri ve basketbol oyun anlayışlarını ölçmeye yönelik olarak uygulanan anketlerin sonucunda, elde edilen verilerle bilgisayarda SPSS program› kullan›larak istatistik çözümleme yapılmıştır. Bu çalışmanın sonuçlarında, her iki ülke arasında ortak yönler bulunurken oldukça farklı yaklaşımlar da göze çarpmıştır. Bu da göstermektedir ki, artık ülkeler arası bilgi alışverişinin artmas›, taktik ve teknik çalışmaların, antrenman uygulamalarının paylaşılması, basketbolda ortak bir anlayış geliştirildiğini göstermektedir. Bununla birlikte ülkelerin ekonomik şartları, spora bakış açıları, altyapı organizasyonları ve antrenör eğitimlerindeki farklılıklar ise ülkelerin basketbol anlayışlarında değişkenlikleri ortaya çıkarmaktadır.The purpose of this study is to contribute to the continuous development and modernization of basketball philosophy in Turkey. An analysis and evaluation of American and Turkish team philosophy and demographic backgrounds of coaches and athletes in elite women’s teams was conducted. The US was chosen because of its success in basketball. A questionnare, developed by the researcher, was administered to both American and Turkish players and coaches. The American sample contains 240 women basketball players and 24 women basketball team coaches from the National Collegiate Athletic Association, while the Turkish sample contains 128 women basketball players and 17 women basketball team coaches from the Turkish Women’s Basketball First League. Demographic information, attitudes towards basketball, and basketball philosophy were extracted from the questionnares employed and were statistically analysed using SPSS. Although information networks have greatly improved among countries in recent years, there is little comparative sports research conducted between countries and specifically none exist in the realm of basketball between the US and Turkey. The results of this study showed that while some similarities exist between both countries, significant differences shed light on success factors. In terms of similarities, the results show that both countries use technique and tactic to achieve practice and game success similiarly. Results also showed that the two countries have a common point of view on the mentality approach to basketball. This study found that the differences between the US and Turkey lay in economic, social and educational factors. This research is relevant to players interested in developing basketball techniques and for coaches interested in improving their basketball philosophy

Familial Sarcoidosis: An Analysis of Twenty-Eight Cases

Objective: Sarcoidosis is a multisystemic disease, exact cause of disease is unknown but it is assumed that genetic predisposition and ethnic factors play a role in etiology. Studies related with familial sarcoidosis is limited and only case reports about familial sarcoidosis is available from our country. We aimed to evaluate the prevelance of familial sarcoidosis and clinical findings of cases with familial sarcoidosis. Methods: We retrospectively documented file records of 678 patients diagnosed with sarcoidosis and followed up in outpatient clinic of sarcoidosis from January 1996 to February 2016. 28 familial sarcoidosis cases in 14 families were enrolled into the study. Their demographic findings, family relationship, symptoms, laboratory and pulmonary function test results, radiological apperances, diagnostic methods, treatments were recorded. Results: Twenty-eight sarcoidosis patients out of 678 reported as familial cases, giving a prevelance of familial sarcoidosis as 4%. There were 8 sarcoidosis sib, 4 sarcoidosis mother-child, 1 sarcoidosis father-child and 1 sarcoidosis cousin relationship. Female/male ratio was 1.8, mean age of the study population was 43, most freguent symptoms were cough and dyspnea, stage 2 was mostly seen according to chest X-ray, most common CT appearance was mediastinal lymphadenopathy and mediastinoscopy was the most freguent diagnostic method. Conclusion: This study is important to lead interrogation of family in patients with suspected sarcoidosis and future studies investigating familial aggregation in sarcoidosis

Nanomechanics on FGF-2 and heparin reveal slip bond characteristics with pH dependency

Fibroblast growth factor 2 (FGF-2), an important paracrine growth factor, binds electrostatically with low micromolar affinity to heparan sulfates present on extracellular matrix proteins. A single molecular analysis served as a basis to decipher the nanomechanical mechanism of the interaction between FGF-2 and the heparan sulfate surrogate, heparin, with a modular atomic force microscope (AFM) design combining magnetic actuators with force measurements at the low force regime (1 × 10¹ to 1 × 10⁴ pN/s). Unbinding events between FGF-2-heparin complexes were specific and short-lived. Binding between FGF-2 and heparin had strong slip bond characteristics as demonstrated by a decrease of lifetime with tensile force on the complex. Unbinding forces between FGF-2 and heparin were further detailed at different pH as relevant for (patho-) physiological conditions. An acidic pH environment (5.5) modulated FGF-2-heparin binding as demonstrated by enhanced rupture forces needed to release FGF-2 from the heparin-FGF-2 complex as compared to physiological conditions. This study provides a mechanistic and hypothesis driven model on how molecular forces may impact FGF-2 release and storage during tissue remodeling and repair

Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (‘Registry’)

Objectives To describe the outcomes of pregnancies in antiphospholipid antibody (aPL)-positive patients since the inception of the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking Registry.Methods We identified persistently aPL-positive patients recorded as ‘pregnant’ during prospective follow-up, and defined ‘aPL-related outcome’ as a composite of: (1) Preterm live delivery (PTLD) at or before 37th week due to pre-eclampsia (PEC), eclampsia, small-for-gestational age (SGA) and/or placental insufficiency (PI); or (2) Otherwise unexplained fetal death after the 10th week of gestation. The primary objective was to describe the characteristics of patients with and without aPL-related composite outcomes based on their first observed pregnancies following registry recruitment.Results Of the 55 first pregnancies observed after registry recruitment among nulliparous and multiparous participants, 15 (27%) resulted in early pregnancy loss <10 weeks gestation. Of the remaining 40 pregnancies: (1) 26 (65%) resulted in term live delivery (TLD), 4 (10%) in PTLD between 34.0 weeks and 36.6 weeks, 5 (12.5%) in PTLD before 34th week, and 5 (12.5%) in fetal death (two associated with genetic anomalies); and (2) The aPL-related composite outcome occurred in 9 (23%). One of 26 (4%) pregnancies with TLD, 3/4 (75%) with PTLD between 34.0 weeks and 36.6 weeks, and 3/5 (60%) with PTLD before 34th week were complicated with PEC, SGA and/or PI. Fifty of 55 (91%) pregnancies were in lupus anticoagulant positive subjects, as well as all pregnancies with aPL-related composite outcome.Conclusion In our multicentre, international, aPL-positive cohort, of 55 first pregnancies observed prospectively, 15 (27%) were complicated by early pregnancy loss. Of the remaining 40 pregnancies, composite pregnancy morbidity was observed in 9 (23%) pregnancies

The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: Results from the APS ACTION cohort

Objectives: To assess whether patients with antiphospholipid syndrome (APS) and history of recurrent thrombosis have higher levels of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) when compared to patients without recurrent thrombosis