Systemizing Virtual Learning and Technologies by Managing Organizational Competency and Talents

The article presents promising components and practices of virtual learning and technologies and discusses how systemization can be made through managing organizational competency and talents. The main goal is to suggest how technologies should be incorporated within an organization to improve the effectiveness of employees’ learning, performance, and development. For technology implementation and adoption, we also introduce models for examining organizational maturity levels and integrating technologies.We argue that virtual learning and technologies are fundamentally pressing HRD roles to change from experts of learning and development to work solution partners leading and supporting the creation of a smart organization.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we sought to describe these mutations and their impact in a subgroup-specific manner. We analyzed the TERT promoter by direct sequencing and genotyping in 466 medulloblastomas. The mutational distributions were determined according to subgroup affiliation, demographics, and clinical, prognostic, and molecular features. Integrated genomics approaches were used to identify specific somatic copy number alterations in TERT promoter-mutated and wild-type tumors. Overall, TERT promoter mutations were identified in 21 % of medulloblastomas. Strikingly, the highest frequencies of TERT mutations were observed in SHH (83 %; 55/66) and WNT (31 %; 4/13) medulloblastomas derived from adult patients. Group 3 and Group 4 harbored this alteration in <5 % of cases and showed no association wit

C-reactive protein goal attainment and multivariate predictors in patients receiving lipid-lowering therapy: analysis of the lipid treatment assessment project 2

Atherosclerosi

C-reactive protein goal attainment and multivariate predictors in patients receiving lipid-lowering therapy: analysis of the lipid treatment assessment project 2

Atherosclerosi