Genome-wide association study of pancreatic fat: The multiethnic cohort adiposity phenotype study

Several studies have found associations between higher pancreatic fat content and adverse health outcomes, such as diabetes and the metabolic syndrome, but investigations into the genetic contributions to pancreatic fat are limited. This genome-wide association study, comprised of 804 participants with MRI-assessed pancreatic fat measurements, was conducted in the ethnically diverse Multiethnic Cohort-Adiposity Phenotype Study (MEC-APS). Two genetic variants reaching genome-wide significance, rs73449607 on chromosome 13q21.2 (Beta = -0.67, P = 4.50x10-8) and rs7996760 on chromosome 6q14 (Beta = -0.90, P = 4.91x10-8) were associated with percent pancreatic fat on the log scale. Rs73449607 was most common in the African American population (13%) and rs79967607 was most common in the European American population (6%). Rs73449607 was also associated with lower risk of type 2 diabetes (OR = 0.95, 95% CI = 0.89-1.00, P = 0.047) in the Population Architecture Genomics and Epidemiology (PAGE) Study and the DIAbetes Genetics Replication and Meta-analysis (DIAGRAM), which included substantial numbers of non-European ancestry participants (53,102 cases and 193,679 controls). Rs73449607 is located in an intergenic region between GSX1 and PLUTO, and rs79967607 is in intron 1 of EPM2A. PLUTO, a lncRNA, regulates transcription of an adjacent gene, PDX1, that controls beta-cell function in the mature pancreas, and EPM2A encodes the protein laforin, which plays a critical role in regulating glycogen production. If validated, these variants may suggest a genetic component for pancreatic fat and a common etiologic link between pancreatic fat and type 2 diabetes

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events42Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases

ANALISIS KESEJAHTERAAN PEMILIK USAHA TRAVEL JASA ANGKUTAN ANTAR KOTA DALAM PROVINSI PADA MASA PANDEMI COVID-19 DI KOTA JAMBI

Skripsi ini bertujuan untuk mengetahui kesejahteraan pemilik usaha travel jasa angkutan antar kota dalam provinsi di kota Jambi, sebagaimana tujuan diantaranya adalah bagaimana dampak dari menurunnya pendapatan terhadap kesejahteraan pemilik usaha travel di kota Jambi. Pada pelitian ini menggunakan pendekatan kualitatif dengan metode pengumpulan data dengan melakukan observasi, wawancara, dokumentasi dan penarikan kesimpulan. Hasil kesimpulan sebagai berikut : (1) Pendapatan pemilik usaha travel jasa angkutan antar kota dalam provinsi di kota jambi sebelum pandemi Covid-19 sangat stabil bahkan meningkat, tetapi sejak pandemi Covid-19 pendapatan usaha travel jasa angkutan antar kota dalam provinsi di kota jambi menurun drastis hingga mencapai 95%. (2) Faktor penyebab penurunan pendapatan pemilik usaha travel jasa angkutan antar kota dalam provinsi pada masa pandemi Covid-19 di kota Jambi yaitu, kebijakan pemerintah pembatasan sosial berskala besar (PSBB), masyarakat takut untuk melakukan perjalanan, penutupan sementara loket travel, kebijakan pemerintah kepada mahasiswa dan pelajar yaitu belajar dari rumah atau daring, pemutusan kerjasama dengan sopir dari penyebab inilah terjadi pengurangan jumlah penumpang. (3) Penurunan pendapatan pemilik usaha travel jasa angkutan antar kota dalam provinsi pada masa pandemi Covid-19 di kota Jambi berdampak pada kesejahteraan pemilik usaha travel yang menyebabkan usaha travel menjual sebagian mobilnya, sopir banyak yang berhenti karena pendapatan tidak cukup untuk memenuhi kebutuhan, usaha travel pindah ke ruko yang lebih kecil yang sewanya lebih murah, usaha travel tutup sementara pada masa Covid-19 karena pendapatan usaha travel mengalami penurunan. Selain dampak negatif yang telah dikemukakan tadi, ada pula dampak positif yaitu sejak adanya pandemi Covid-19 pemilik usaha travel lebih mendekatkan diri kepada Allah SWT. (4) Upaya-upaya yang dilakukan pemilik usaha travel jasa angkutan antar kota dalam provinsi pada masa pandemi Covid-19 di kota Jambi untuk tetap bertahan yaitu menggunakan media sosial buat promosi untuk menarik pelanggan

Kondisi Fertilitas Mencit Jantan yang Diberi Ekstrak Etanol Akar Alang-alang (Imperata cylindrica)

Pengendalian populasi hewan umumnya dilakukan dengan sterilisasi. Namun biaya yang diperlukan cenderung mahal sehingga diperlukan tindakan lain untuk mengendalikan populasi hewan. Pemanfaatan tumbuhan sebagai herbal yang digunakan untuk kontrasepsi alami hewan sedang dikembangkan. Pada penelitian sebelumnya diketahui bahwa pemberian ekstrak etanol akar alang-alang menyebabkan penurunan bobot kelenjar testis, vesical seminalis dan epididimis sehingga menyebabkan penurunan produksi spermatozoa dan perubahan profil metabolit pada mencit jantan. Namun, pengaruh ekstrak etanol akar alang-alang terhadap morfometri fetus dari mencit betina dikawinkan dengan mencit jantan perlakuanbelum diketahui. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol akar alang-alang hasil konsepsi mencit jantan pada mencit betina yang tidak diberi perlakuan. Mencit jantan diberi ekstrak etanol akar alang-alang selama 180 hari (Imperata cylindrica) 90 dan 115 mg/kg BB per oral kemudian dikawinkan dengan mencit betina yang tidak diberi perlakuan. Hasil penelitian menunjukkan bahwa terjadi penurunan jumlah fetus, berat badan dan panjang fetus pada kelompok perlakuan 90 dan 115 mg/kgBB. Pemberian ekstrak etanol akar alang-alang pada mencit jantan berpengaruh secara signifikan terhadap jumlah mencit betina yang bunting dan morfometri fetus yang dikandung mencit betina

An update of cost-effectiveness of rotavirus vaccination in indonesia: Takinga birth-dose vaccination strategy into account

Objectives: Rotavirus infection was reported as the major cause of severe diarrhea in children under 5-years-old in Indonesia. A low cost rotavirus vaccine to protect infants from birth has been developed for developing countries, such as Indonesia. This study aims to update our initial analysis on the cost-effectiveness of rotavirus vaccination in Indonesia, taking a birth-dose vaccination strategy explicitly into account. Methods: An age-structured cohort model was developed for the 2013 Indonesia birth cohort. Applying different rotavirus vaccine efficacies for formula-fed and breastfed infants, we compared two vaccination strategies: (i) three-dose schedule at 2, 3 and 4 months of age, and (ii) three-dose schedule at 0, 1, and 2 months of age. We applied a 5-year-time-horizon with 1 monthly analytical cycles for children less than 1 year of age and annually thereafter. Also, we used Monte Carlo simulations to examine the economic acceptability and affordability of the rotavirus vaccination. Results: Rotavirus vaccination would reduce rotavirus-diarrhea cases in children under 5-years-old by 475,806 and 489,259 cases for the first and second strategies, respectively. Considering amarket price of US$5 per dose, the Indonesian government would require budgets of US$ 65.0 million and US$65.3 million for the first and second strategies, respectively.The incremental cost-effectiveness ratios wereUS$ 150 and US$146for the first and second strategies, respectively, which were much lower than the 2013 Indonesian Gross Domestic Product (GDP) per capita of US$ 4,790. Conclusions: The implementation of a birth-dose rotavirusvaccination strategy in Indonesia would be more cost-effective than a later vaccination schedule. The mortality rate and vaccine price were the most influential parameters impacting the costeffectiveness results

The stability of Co3O4, Fe2O3, Au/Co3O4 and Au/Fe2O3 catalysts in the catalytic combustion of lean methane mixtures in the presence of water

Nano-sized Co3O4, Fe2O3, Au/Co3O4 and Au/Fe2O3 catalysts were prepared and evaluated for catalytic combustion of lean methane-air mixtures. Characteristics and catalytic activities under dry and wet feed conditions were investigated at gas hourly space velocities up to 100000h-1 mimicking the typical flow and conversion requirements of a catalytic system designed to treat a ventilation air methane stream. In order to gain a better understanding of the interaction between H2O and the catalyst surface, temperature-programmed desorption of water over fresh and used samples were studied, and supported by other catalyst characterization techniques such as N2-adsorption desorption, XRD, TEM, SEM and XPS analyses. The activity measurements of the catalysts studied identify Co3O4 as the most active material. Co-precipitating gold particles with cobalt oxide or iron oxide do not enhance the activity of the catalyst, which is most likely due to blocking the active site of support by the gold particle. The presence of strong hydroxyl bonds on the catalyst surface is substantiated by TPD and XPS analyses, and is suggested to be responsible for the rapid deactivation of Fe2O3 and Au/Fe2O3 catalysts

Sanksi Pidana terhadap Pelaku Tindak Pidana Penggelapan dalam Situs Jual Beli Online

Nowadays in the world of electronic transactions many deviant acts are found, and are not based on existing legal norms, which mostly occur in the online trading system. Online sales and purchases are sometimes only based on trust, which means that the perpetrators of trade are sometimes unclear. Thus, this study was conducted to determine the legal arrangements regarding the actions that have been carried out by business actors to consumers and criminal sanctions imposed on perpetrators of embezzlement in online trading sites. This study uses a normative method because there are still vague norms, based on the opinions of legal scholars and the Law. Prohibition of business actors in marketing activities is regulated in Article 9 paragraph 1 of the Consumer Protection Act prohibiting business actors from offering, promoting, advertising goods and / or services incorrectly or as if the goods have fulfilled and have discounted prices, special prices , certain quality standards, certain styles or modes, certain characteristics, certain history or uses, the goods are in good or new condition, the goods and services have been obtained or have a sponsor, approval, certain equipment, certain benefits. Crimes of embezzlement are based on the provisions of article 372 KUHP, which means that someone who has someone's belongings with the intention of violating the law is an embezzlement