Magnetic resonance spectroscopy in ring enhancing lesions

We report a 4 year old girl with ring enhancing lesions in brain CT, initially diagnosed as neurocysticercosis but did not respond to cysticidal therapy. A Magnetic resonance spectropscopy (MRS) revealed lipid peaks suggestive of tuberculoma which was successfully treated with antituberculosis therapy. This report highlights the role of MRS in the diagnosis of ring enhancing lesios

Complexes of Lewis Bases with Zn (II), Cd (II), Hg (II), Fe (II), Pd(II), Co(II), Ni(II) & Cu(II) Thiocyanates & Cyanates

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Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus

Abstract Introduction There is a growing body of evidence implicating aberrant dendritic cell function as a crucial component in the immunopathogenesis of systemic lupus erythematosus. The purpose of the present study was to characterize the phagocytic capacity and expression of receptors involved in pathogen recognition and self-nonself discrimination on myeloid dendritic cells from patients with lupus. Methods Unstimulated or stimulated monocyte-derived dendritic cells were obtained from lupus patients and healthy control individuals, and expression of C-type lectin receptors (mannose receptor and dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin), complement-receptor 3 and Fcγ receptors was determined by flow cytometry. Dextran uptake by lupus and control dendritic cells was also assessed by flow cytometry. Serum IFNγ was quantified by ELISA, and uptake of microbial products was measured using fluorescently labeled zymosan. Results When compared with dendritic cells from healthy control individuals, unstimulated and stimulated lupus dendritic cells displayed significantly decreased dextran uptake and mannose receptor and dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin expression. Decreased expression of the mannose receptor was associated with high serum IFNγ levels, but not with maturation status or medications. Diminished dextran uptake and mannose receptor expression correlated with lupus disease activity. There were no differences between control and lupus dendritic cells in the expression of other pattern recognition receptors or in the capacity to uptake zymosan particles Conclusions Lupus dendritic cells have diminished endocytic capacity, which correlates with decreased mannose receptor expression. While this phenomenon appears primarily intrinsic to dendritic cells, modulation by serum factors such as IFNγ could play a role. These abnormalities may be relevant to the aberrant immune homeostasis and the increased susceptibility to infections described in lupus.http://deepblue.lib.umich.edu/bitstream/2027.42/112498/1/13075_2008_Article_2366.pd

Tons of excreta and ways to treat them

In most cities in developing or newly industrialised countries, collection, haulage and treatment of faecal sludges (FS) from latrines, aqua privies and septic tanks pose a multitude of problems. Due to excessive haulage distances and to a lack of suitable treatment options, the sludges are normally dumped untreated within the shortest possible distance. To illustrate the quantitative aspect of the problem, e.g. Manila and Bangkok, where 65 per cent of the population are served by septic tanks, will have to deal daily with the haulage and treatment of 300 and 500 tanker loads, respectively, in the near future; i.e., when emptying services will have been improved (Veroy, Arellano and Sahagun 1994; Stoll 1995). Only in a few countries (e.g. Ghana, Thailand, Indonesia, and Argentina), purposely designed treatment plants exist to treat septage and nightsoil. In some countries (e.g. Botswana, Tanzania, South Africa), FS are added to the urban wastewater stream for cotreatment in wastewater treatment plants; generally waste stabilisation ponds (WSP). These are frequently overloaded and malfunctioning as they are not originally designed to receive the additional load

Effects of chromium on the immune system

Chromium is a naturally occurring heavy metal found commonly in the environment in trivalent, Cr(III), and hexavalent, Cr(VI), forms. Cr(VI) compounds have been declared as a potent occupational carcinogen among workers in chrome plating, stainless steel, and pigment industries. The reduction of Cr(VI) to Cr(III) results in the formation of reactive intermediates that together with oxidative stress oxidative tissue damage and a cascade of cellular events including modulation of apoptosis regulatory gene p53, contribute to the cytotoxicity, genotoxicity and carcinogenicity of Cr(VI)-containing compounds. On the other hand, chromium is an essential nutrient required to promote the action of insulin in body tissues so that the body can use sugars, proteins and fats. Chromium is of significant importance in altering the immune response by immunostimulatory or immunosuppressive processes as shown by its effects on T and B lymphocytes, macrophages, cytokine production and the immune response that may induce hypersensitivity reactions. This review gives an overview of the effects of chromium on the immune system of the body

Additivity properties of a Gaussian Channel

The Amosov-Holevo-Werner conjecture implies the additivity of the minimum Re'nyi entropies at the output of a channel. The conjecture is proven true for all Re'nyi entropies of integer order greater than two in a class of Gaussian bosonic channel where the input signal is randomly displaced or where it is coupled linearly to an external environment.Comment: 9 pages, 1 figure (minor error present in the published version corrected

Minimum Renyi and Wehrl entropies at the output of bosonic channels

The minimum Renyi and Wehrl output entropies are found for bosonic channels in which the signal photons are either randomly displaced by a Gaussian distribution (classical-noise channel), or in which they are coupled to a thermal environment through lossy propagation (thermal-noise channel). It is shown that the Renyi output entropies of integer orders z>1 and the output Wehrl entropy are minimized when the channel input is a coherent state.Comment: Minimal revision. Accepted for publication on Phys. Rev.

Positioning and clock synchronization through entanglement

A method is proposed to employ entangled and squeezed light for determining the position of a party and for synchronizing distant clocks. An accuracy gain over analogous protocols that employ classical resources is demonstrated and a quantum-cryptographic positioning application is given, which allows only trusted parties to learn the position of whatever must be localized. The presence of a lossy channel and imperfect photodetection is considered. The advantages in using partially entangled states is discussed.Comment: Revised version. 9 pages, 6 figure

Suboptimal chlorine treatment of drinking water leads to selection of multidrug-resistant Pseudomonas aeruginosa

The present study was undertaken to investigate the spectrum of bacteria present in the River Gomti water before and after chlorination for drinking purposes. We observed that the strains of Pseudomonas aeruginosa that survived chlorination on three out of seven occasions were resistant to almost all the antibiotics tested. The chlorine-resistant bacteria had mucoid colonies and grew better at 24° C. All attempts to isolate the plasmid responsible for chlorine resistance were unsuccessful. Laboratory experiments using different strains of the P. aeruginosa in distilled water showed that only the resistant strain survived chlorine treatment at a dose of ≤500 μ g/L. Similar results were obtained when water collected from seven different sites on the River Gomti was treated with graded doses of chlorine. At the higher dose of chlorine, all the bacteria died in 30 min, whereas with lower doses all the bacteria survived. The present study underscores the importance of measuring water chlorine concentrations to assure they are sufficiently high to remove pathogenic bacteria from drinking water. To our knowledge, this is the first report in the literature of the selection of multidrug-resistant bacteria by suboptimal chlorine treatment of water