La fractura en la sociedad política catalana en vísperas del Compromiso de Caspe

The five years preceding the death of Martin I the privileged groups of Cataluña, confront at the Parliament gathered in Perpignan, Sant Cugat and Barcelona because of the Princedom Political conception, that avoids progress and shows a ruptury between the nobility and cavalry memberships, which explains the defeat of the Count of Urgel at the succession of the Crown of Aragon.[fr] Durant les cinq années qui précédèrent la mort du Martin I, aux Assemblées réunies de Perpignan, Sant Cugat et Barcelona, les groupes privilégiés de la Catalogne se virent confrontés quant à la conception politique de la Principauté. Ceci empêchait tout progrès et reflétait une rupture entre les membres de la noblesse et ceux de la cavalerie ce qui explique la défaite du Comte d'Urgel à la succession au trône de la Couronne d'Aragon

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Aragón, los aragoneses y el Fuero de Jaca : (siglos XI-XII)

Copia digital. Zaragoza, 200

La escuela de medievalismo de Zaragoza.

Este año se cumple el centenario del nacimiento de José María Lacarra (1907-1987), catedrático de Historia Medieval de la Universidad de Zaragoza durante treinta y seis años, uno de los medievalistas más relevantes de la historiografía española del pasado siglo y en gran medida responsable del impulso experimentado por los estudios de la Edad Media en nuestro país. (...