Efectividad del tratamiento del miembro superior en parálisis cerebral mediante la terapia de movimiento inducido por restricción en comparación con terapia bimanual: una revisión bibliográfica

La parálisis cerebral (PC) es la causa más común de discapacidad física en la infancia. Su prevalencia es alrededor de 2 por 1000 nacidos vivos.La forma de afectación es heterogénea, siendo la anamnesis, el estudio de los hitos del desarrollo psicomotor y el examen clínico lo fundamental para su diagnóstico.Una de las afectaciones, es la hemiplegia, en la que un lado del cuerpo se ve más afectado que el otro. Existen diversos tratamientos, entre ellos la terapia de movimiento inducido por restricción (CMIT) y la terapia bimanual (HABIT). <br /

El Concejo de Huesca en la Edad Media: Estructura, funcionamiento y financiación de la organización municipal en la Baja Edad Media

El tema de la tesis es el surgimiento, evolución y consolidación del gobierno urbano de la ciudad de Huesca en el periodo que se extiende desde finales del siglo XI hasta los inicios del estado moderno, un estudio planteado desde la perspectiva de historia social de las instituciones. El trabajo aborda el análisis de la organización pública que constituyó el concejo medieval oscense en relación con la composición social y los intereses políticos y económicos de los grupos dirigentes de la ciudad. Una de las aportaciones más interesantes es la aplicación del método pospográfico al estudio de la composición de las élites dirigentes locales, integradas en Huesca por ciudadanos e infanzones, nobles de segundo rango que pactaron el derecho de participación en el gobierno municipal a cambio de contribuir en los gastos vecinales. Las finanzas locales en la segunda mitad del siglo XV ocupan una parte sustancial del trabajo. Los modelos fiscales y el análisis del mercado de deuda pública sientan las bases de una nueva forma de comportamiento en la gestión financiera, que explica la estrecha relación entre finanzas locales y oligarquía. Acompaña al texto un volumen con los apéndices: una selección de documentos inéditos relevantes para el tema de estudio, las bases de datos sobre la composición de los gobiernos de los ciudadanos e infanzones, así como cuadros explicativos sobre la hacienda municipal y algunos planos de la evolución urbana de la ciudad medieval y su territorio

Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson's disease

The neurotransmitter serotonin (5-HT) has a multifaceted function in the modulation of information processing through the activation of multiple receptor families, including G-protein-coupled receptor subtypes (5-HT1, 5-HT2, 5-HT4-7) and ligand-gated ion channels (5-HT3). The largest population of serotonergic neurons is located in the midbrain, specifically in the raphe nuclei. Although the medial and dorsal raphe nucleus (DRN) share common projecting areas, in the basal ganglia (BG) nuclei serotonergic innervations come mainly from the DRN. The BG are a highly organized network of subcortical nuclei composed of the striatum (caudate and putamen), subthalamic nucleus (STN), internal and external globus pallidus (or entopeduncular nucleus in rodents, GPi/EP and GPe) and substantia nigra (pars compacta, SNc, and pars reticulata, SNr). The BG are part of the cortico-BG-thalamic circuits, which play a role in many functions like motor control, emotion, and cognition and are critically involved in diseases such as Parkinson's disease (PD). This review provides an overview of serotonergic modulation of the BG at the functional level and a discussion of how this interaction may be relevant to treating PD and the motor complications induced by chronic treatment with L-DOPA.This study was supported by the grants IT747-13, PI12/00613, UPV/EHU UFI11/32

Parlamentos del Interregno (1410-1412)

En la port.: Grupo C.E.M.A., Universidad de Zaragoza; Cortes de Aragón.Vol. 1 : Actas del Parlamento de Alcañiz-Zaragoza (1411-1412) .-- Vol. 2: Actas del Parlamento de Alcañiz-Zaragoza (1411-1412) (continuación); Actas del Compromiso de Caspe (1412); Sentencia del Compromiso de Caspe (25 junio 1412

Characterization of multiple SPS knockout mutants reveals redundant functions of the four Arabidopsis sucrose phosphate synthase isoforms in plant viability, and strongly indicates that enhanced respiration and accelerated starch turnover can alleviate the blockage of sucrose biosynthesis

We characterized multiple knock-out mutants of the four Arabidopsis sucrose phosphate synthase (SPSA1, SPSA2, SPSB and SPSC) isoforms. Despite their reduced SPS activity, spsa1/spsa2, spsa1/spsb, spsa2/spsb, spsa2/spsc, spsb/spsc, spsa1/spsa2/spsb and spsa2/spsb/spsc mutants displayed wild type (WT) vegetative and reproductive morphology, and showed WT photosynthetic capacity and respiration. In contrast, growth of rosettes, flowers and siliques of the spsa1/spsc and spsa1/spsa2/spsc mutants was reduced compared with WT plants. Furthermore, these plants displayed a high dark respiration phenotype. spsa1/spsb/spsc and spsa1/spsa2/spsb/spsc seeds poorly germinated and produced aberrant and sterile plants. Leaves of all viable sps mutants, except spsa1/spsc and spsa1/spsa2/spsc, accumulated WT levels of nonstructural carbohydrates. spsa1/spsc leaves possessed high levels of metabolic intermediates and activities of enzymes of the glycolytic and tricarboxylic acid cycle pathways, and accumulated high levels of metabolic intermediates of the nocturnal starch-to-sucrose conversion process, even under continuous light conditions. Results presented in this work show that SPS is essential for plant viability, reveal redundant functions of the four SPS isoforms in processes that are important for plant growth and nonstructural carbohydrate metabolism, and strongly indicate that accelerated starch turnover and enhanced respiration can alleviate the blockage of sucrose biosynthesis in spsa1/spsc leaves.This work was partially supported by the Comisión Interministerial de Ciencia y Tecnología and Fondo Europeo de Desarrollo Regional (Spain) [grant numbers BIO2010-18239, BIO2013-49125-C2-1-P, BIO2008-02292 and BIO2011-28847-C02-02]. A.M.S-L. acknowledges a predoctoral fellowship from the Spanish Ministry of Science and Innovation. M.B. acknowledges a post-doctoral fellowship from the Public University of Navarra.Peer Reviewe

Correlation between serum advanced glycation end products and dietary intake of advanced glycation end products estimated from home cooking and food frequency questionnaires

Abstract Background & aims: To our knowledge the association between dietary advanced glycation end-products (dAGEs) and cardiometabolic disease is limited. Our aim was to examine the association between dAGEs and serum concentration of carboxymethyl-lysine (CML) or soluble receptor advanced glycation end-products (sRAGEs), and to assess the difference on dAGEs and circulating AGEs according to lifestyle and biochemical measures. Methods and results: 52 overweight or obese adults diagnosed with type 2 diabetes were included in this cross-sectional analysis. dAGEs were estimated from a Food Frequency Questionnaire (FFQ) or from a FFQ þ Home Cooking Frequency Questionnaire (HCFQ). Serum concentrations of CML and sRAGEs were measured by ELISA. Correlation tests were used to analyze the association between dAGEs derived from the FFQ or FFQ þ HCFQ and concentrations of CML or sRAGEs. Demographic characteristics, lifestyle factors and biochemical measures were analyzed according to sRAGEs and dAGEs using student t-test and ANCOVA. A significant inverse association was found between serum sRAGEs and dAGEs estimated using the FFQ þ HCFQ (r Z 0.36, p Z 0.010), whereas no association was found for dAGEs derived from the FFQ alone. No association was observed between CML and dAGEs. dAGEs intake estimated from the FFQ þ HCFQ was significantly higher among younger and male participants, and in those with higher BMI, higher Hb1Ac levels, longer time with type 2 diabetes, lower adherence to Mediterranean diet, and higher use of culinary techniques that generate more AGEs (all p values p < 0.05). Conclusions: These results show knowledge on culinary techniques is relevant to derive the association between dAGEs intake and cardiometabolic risk factors

Soil application of volatile compounds emitted by Alternaria alternata enhance yield of pepper plants cultured under greenhouse conditions

Póster presentado en el 2nd World Congress on the use of Biostimulants in Agriculture, celebrado en Florencia del 16 al 19 de noviembre de 2015.Peer Reviewe

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice

Even though the idea that amyloid β peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this type of dementia remains controversial. We further investigated the role of β-amyloid production/deposition in tau pathology and neuronal cell death in the mouse brain by crossing Tg2576 and VLW lines expressing human mutant amyloid precursor protein and human mutant tau, respectively. The resulting double transgenic mice showed enhanced amyloid deposition accompanied by neurofibrillary degeneration and overt neuronal loss in selectively vulnerable brain limbic areas. These findings challenge the idea that tau pathology in Alzheimer's disease is merely a downstream effect of amyloid production/deposition and suggest that reciprocal interactions between β-amyloid and tau alterations may take place in vivo.This project was funded in part by EC grant DIADEM QRLT-2000-026362, SAF2004-07802 and UTE project CIM

Subcellular localization of enzymes in carbohydrate metabolism in the effort to improve production parameters

Trabajo presentado en el Olomouc Biotech 2011 Plant Biotechnology (Green for Good), celebrado en Olomouc (República Checa) del 19 al 22 de junio de 2011.Peer Reviewe

Dual targeting to mitochondria and plastids of AtBT1 and ZmBT1, two members of the mitochondrial carrier family

Póster presentado en la The Annual Plant Biology Meeting, celebrada en Minneapolis del 6 al 10 de agosto de 2011.Peer Reviewe