¿Un visionario del turismo o un gestor incompetente? El marqués de la Vega-Inclán, primer comisario regio de turismo

Es importante pararnos a pensar y plantearnos realmente cuáles son los orígenes de las políticas turísticas en nuestro país y si esas iniciativas realmente sentaron las bases de la política turística actual que tan buenos resultados está cosechando. Para ello vamos a viajar atrás en el tiempo hasta principios del siglo XX y dedicaremos este estudio a analizar la figura del II Marqués de la Vega Inclán, personaje clave en la historia turística española. A través de su biografía, del contexto cultural e histórico de la época, de su obra y de las opiniones que diferentes historiadores tienen de este personaje de principios de siglo descubriremos si era realmente un auténtico visionario o un gestor incompetente.Departamento de Historia Moderna, Contemporánea y de América, Periodismo y Comunicación Audiovisual y PublicidadGrado en Turism

Dissolved oxygen determination in two-dimensional tissue cultures using optical sensors

Oxygen concentration determination is of importance across many different industries, biomedical research among them. In biological systems, in vivo oxygen levels vary across a wide spectrum and strongly influence function of cells and tissues. Direct measurements of oxygen tension and its progression in real-time are necessary in order to understand and control cell survival, proliferation and differentation. In this thesis, special attention is payed to skin tissue. An in-depth understanding of these aspects will allow to provide better diagnostic and therapeutic tools for wound care. The general objective of this thesis is to analyze dissolved oxygen concentration in a two-dimensional tissue culture of a keratinocyte cell line (HaCaT) via the development and application to this purpose of an optical sensor. The sensor is based on a metalloporphyrin membrane (PtOEP) that emits a fluorescence signal that is quenched by oxygen in the environment. Images of the membrane are captured using time-lapse microscopy with a filter at the desired wavelength. Average pixel value is then analyzed, as it is directly related to O2 concentration. The porphyrin-based optical sensor developed in this work is proved to be compatible with cell culture. Using this sensor, changes in oxygen concentration in a physiological range can be detected. Dissolved O2 concentration in culture medium is found to decrease at high cell densities as a result of O2 consumption. It is also possible monitor discontinuities in a monolayer of cells by detection of local O2 concentration using this sensor.Ingeniería Biomédic

Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines

The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. In particular, the tetrahydro-1H-[3]- benzazepine is a common skeleton in a number of natural and pharmaceutical products. As consequence of the interesting biological properties, derivatives of the tetrahydro-1H-[3]-benzazepines, especially the 1-aryl substituted have been synthesized by different routes and evaluated their pharmacologic activity. [1,2] The stereoselective synthetic approaches of tetrahydro-1H-[3]-benzazepine have focused on ring enlargements, as the Stevens rearrangement (SR) which is a good regio- and diastereoselective synthetic methodology. In my research group, the reaction conditions to synthesize tetrahydro-1H-[3]-benzazepines 1,2-disubstituted by via SR from tetrahydroisoquinolinium salts conveniently functionalized have been optimized. [3,4] This methodology allowed us to obtain a wide variety of tetrahydro-1H-[3]- benzazepines 1,2-disubstituted with different substituents at A-ring (Cl, OMe) and the C-1 (-C6H4X, X = H, OMe, Cl, NO2, NMe2, NH2, SMe) and C-2 (Electron-withdrawing groups) positions. The demethylation of the synthesized tetrahydroisoquinolines and tetrahydro-1H-[3]-benzazepines 1,2-disubstituted, lead us to get catechol structure, an important requirement for their dopaminergic activity. We have studied the dopaminergic activity of the synthesized compounds by radioligand binding assays, establishing a structure-activity relationships. Literature: [1] A. Gini, Adv. Synth. Catal. 2016, 358, 4049. [2] H. Damsen, Eur. J. Org. Chem. 2015, 36, 7880. [3] M. Valpuesta, Eur. J. Org. Chem. 2010, 23, 4393. [4] M. Ariza, Eur. J. Org. Chem. 2011, 32, 6507.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Synthesis of bioactive compounds. Studies of their attachment to nanoparticles

The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of 1-aryl tetrahydroisoquinoline are used for the treatment of neurodegenerative diseases such as Parkinson´s and Alzheimer´s diseases since also act as dopaminergic antagonists and N-methyl-D-aspartate receptor antagonist. [1] The 1-substituted tetrahydro-3-benzazepines have also been studied for their affinity to the Phencylclidine binding site of the NMDA receptor as well as for their affinity to the dopaminergic receptors. [2] In the last years, various methods have been carried out to satisfy the demand of novel tetrahydroisoquinolines and tetrahydro-3-benzazepines. We have synthesized nor-1-aryl tetrahydroisoquinolines with different substituents in the aryl group of C-1 (H, NMe2, SMe, NO2, NH2). In addition to this, we have performed the synthesis of nor-tetrahydro-3-benzazepinas by different routes, obtaining the best results via opening of epoxides by arylphenethylamines and subsequent cyclization. The nor-tetrahydroisoquinolines and nor-tetrahydro-3-benzazepines have been derivatized to obtain appropiate adsorbates which can be attached to nanoparticles. This fact is crutial in drug delivery systems as well as in the improvement of the biocompatibility of these compounds. Literature: [1] Toshiaki Saitoh, Eur. J. Med. Chem. 2006, 41, 241. Mattias Ludwig, Eur. J. Med. 2006, 41, 1003. [2] Olaf Krull, Bioorg. Med. Chem. 2004, 12, 1439.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Squaring the circle: The BHLS concept

The transport systems known as Bus Rapid Transit (BRT) was launched in Curitiba, Brazil, in 1974 as a means of offering efficient and effective bus travel within the fast expanding city. This experience, together with other big examples like in Ottawa (since 1983) or in Quito (since 1994), have proven to be an efficient and effective solution to mass transport. Throughout Europe similar experiences have started to be developed, but responding to a different concept of quality of service. Bus systems such as the “trunk network”, in Sweden, the Metrobus, in Germany, or the BHNS (Bus à Haut Niveau de Service), broach the quality of service from a wider perspective than the BRT, as it considers aspects such as image, confort...,apart from speed, frequency or reliability. These new systems - BHLS (Buses with a High Quality of Service) - allow to combine quality of service of tramways with the lower costs and higher flexibility of bus systems, and offers very interesting solutions in terms of accessibility, a wide range of service levels, that allows the system to be adapted to the different urban contexts (size, population, density…) In the economic situation we are now living, the lack of funds provides BHLS an important role in public transport. Less costs with the same quality of service seems to be a very attractive option. The aim of this article is to compare the different European experiences of tramways and BHLS, specially from the economic point of view, considering the costs, benefits and advantages of each of them

Del BRT al BHLS: un enfoque europeo de los sistemas de transporte masivo en autobús.

Los sistemas conocidos como Bus Rapid Transit (BRT), nacidos en Estados Unidos en la década de los 70, han mostrado ser una solución tan eficaz como eficiente para el transporte de masas. La evolución del concepto, hasta lo que actualmente se denomina BHLS (Bus with a High Level of Service), permite combinar las ventajas de los tranvías en cuanto a velocidad, frecuencia, imagen, confort, etc., con los menores costes y el nivel de capacidad y flexibilidad que los autobuses conllevan. Una cuadratura del círculo que coloca a este nuevo sistema a medio camino entre el tranvía y los autobuses digamos regulares, adoptando las ventajas de uno y otro. En un momento económico como el actual, es evidente que la limitación- cuando no falta- de fondos abre para el BHLS todo un campo de oportunidades en las áreas urbanas como un atractivo modo de transporte que combina la calidad de los modos ferroviarios con la flexibilidad de los autobuses. Es, precisamente, el contexto socio económico actual el que lleva a las autoras a reflexionar acerca de las ventajas comparativas, sobre todo desde el punto de vista financiero, de estos tres sistemas de transporte de masas: autobús, ferrocarril y, finalmente, el BHLS. El análisis de costes, puesto en relación con los beneficios y ventajas que cada sistema lleva asociados, permitirá extraer una serie de conclusiones acerca de sus posibilidades reales como el innovador sistema de transporte de masas que pretende ser

Efectos de la vecindad y la Inspección de Trabajo sobre los índices de siniestralidad provinciales

Se pretende saber si la labor del organismo responsable de la Inspección de Trabajo y Seguridad Social (ITSS) es eficaz. Para ello, se va a evaluar si la intensidad de la inspección laboral se traduce en una reducción de los accidentes de trabajo. Con esta finalidad se utiliza información procedente de la estadística de accidentes de trabajo y de la Inspección de Trabajo y se realizan estimaciones multivariantes que permiten analizar qué factores son los más determinantes a la hora de explicar el nivel de siniestralidad laboral de las diferentes provincias españolas durante los años 20007, 2012 y 2017.Departamento de Fundamentos del Análisis Económico e Historia e Instituciones EconómicasGrado en Administración y Dirección de Empresa

Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors

The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high affinity and selectivity of this tetrahydro-1H-[3]-benzazepine has led to the search for new structures because of their potential dopaminergic activity, especially 1-aryl-substituted tetrahydro-1H-[3]-benzazepines. Furthermore, their precursors, the tetrahydroisoquinolines 1-substituted have shown to have activity for D1 and D2 dopaminergic receptors.[2] We have carried out the synthesis of tetrahydro-1H-[3]-benzazepines 1,2-di-substituted by Stevens rearrangement (SR) on tetrahydroisoquinolinium salts. Stevens rearrangement is an efficient regio- and diastereoselective synthetic methodology. [3a,b] As part of our studies, we have performed the synthesis of benzazepines with modifications at the C-1 and C-2 positions with chlorine and hydroxyl groups at A-ring which is an important factor to modulate affinity at dopaminergic receptors. The interaction of these molecules with D1 and D2 dopaminergic receptors have been studied to establish a structure-activity relationship by radioligand binding assays.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Rhodium and Iridium complexes with a new scorpionate phosphane ligand

A straightforward synthesis of a new hybrid scorpionate ligand [(allyl)2B(CH2PPh2)(Pz)]− ([A2BPN]−) is reported. Coordination to rhodium resulted in square-planar complexes [Rh(κ2-A2BPN)(L)(L′)] [L = L′ = 1/2cod (1,5-cyclooctadiene), CNtBu, CO (6); L = CO, L′ = NH3, pyridine, PPh3, PMe3] for which spectroscopic data and the molecular structure of [Rh(κ2-A2BPN)(CO)PPh3] (11) indicate the ligand to be κN,κP-bound to rhodium with two dangling free allyl groups. Studies in solution point out that the six-membered Rh–N–N–B–C–P metallacycle undergoes a fast inversion in all of them. The bis(carbonyl) complex 6 easily loses a CO group to give [{Rh(A2BPN)(CO)}2], a dinuclear compound in which two mononuclear subunits are brought together by two bridging allyl groups. Coordination to iridium is dominated by a tripodal κN,κP,η2-C═C binding mode in the TBPY-5 complexes [Ir(κ3-A2BPN)(L)(L′)] [L = L′ = 1/2cod (3), CNtBu (5), CO (7); L = CO, L′ = PPh3 (13), PMe3 (14), H2C═CH2, (17), MeO2CC≡CCO2Me (dmad, 18)], as confirmed by the single-crystal structure determination of complexes 3 and 18. A fast exchange between the two allyl arms is observed for complexes having L = L′ (3, 5, and 7), while those having CO and L ligands (14, 17, and 18) were found to be nonfluxional species. An exception is complex 13, which establishes an equilibrium with the SP-4 configuration. Protonation reactions on complexes 13 and 14 with HCl yielded the hydride complex [Ir(κ2-A2BPN)(CO)(Cl)(H)PPh3] (15) and the C-alkyl compound [Ir{κ3-(allyl)B(CH2CHCH3)(CH2PPh2)(Pz)}(Cl)(CO)PMe3] (16), respectively. The bis(isocyanide) complex 5 reacts with dmad to form [Ir(κ2-A2BPN)(CNtBu)2(dmad)]. On the whole, the electronic density provided to the metal by the [A2BPN]− ligand is very sensitive to the coordination mode. The basicity of the new ligand is similar to that of the TpMe2 ligand in the κN,κP mode but comparable to Tp if coordinated in the κN,κP,η2-C═C mode.This research was supported by the MICINN/FEDER (Project CTQ2011-22516, Spain), Gobierno de Aragón (GA)/FSE (E70), and GA-La Caixa (Grant 2012/GA LC 057). A.L.S. thanks MICINN/FEDER for a fellowship.Peer Reviewe

Evaluación formativa basada en la interacción con profesionales externos al ámbito universitario

[EN] In order to contribute to the design of the continuous evaluation and training evaluation, this paper presents a teaching experience proposing a shared assessment, with the assistance of three independent experts (nonacademic), who participated in the overall grade of the course and in the students' learning process. The results show that this involvement of professionals in the classroom allow extending and enriching the information received by the students on their learning development.[ES] Con la finalidad de contribuir al diseño de sistemas de evaluación continua y formativa, se presenta una experiencia docente con una propuesta de valoración compartida del trabajo de los alumnos. Para ello se contó con la colaboración de tres profesionales externos al ámbito universitario, quienes participaron tanto en la calificación de la asignatura, como en el proceso de aprendizaje del alumnado. Los resultados muestran que la implicación de los profesionales, a través de sus comentarios, recomendaciones y sugerencias de mejora, permitió ampliar y enriquecer la información que recibe el alumno sobre su propio desarrollo.López-Cózar, C.; Alarcón, S.; Serrano, A. (2017). Evaluación formativa basada en la interacción con profesionales externos al ámbito universitario. En In-Red 2017. III Congreso Nacional de innovación educativa y de docencia en red. Editorial Universitat Politècnica de València. 1283-1292. https://doi.org/10.4995/INRED2017.2017.6840OCS1283129