Quaternary glacial evolution in the Central Cantabrian Mountains (Northern Spain)

Peer reviewedPostprin

Apparent digestibility and metabolizable energy content of lipid sources in poultry

A trial was conducted to determine the apparent digestibility (ATTD) and AME content of different lipid sources in 21d-old broilers. There were a control diet based on corn and soybean meal without any supplemental fat and 6 additional diets forming a 3x2 factorial with 3 sources of fat (soy oil, SBO; reconstituted monoglyceride oil, RMG; and reconstituted triglyceride oil, RTG) included in the diet (3 or 6%) at expenses (wt:wt) of the basal diet

Effects of immersive and non-immersive virtual reality on the static and dynamic balance of stroke patients: A systematic review and meta-analysis

(1) Background: The development of new technologies means that the use of virtual reality is increasingly being implemented in rehabilitative approaches for adult stroke patients. Objective: To analyze the existing scientific evidence regarding the application of immersive and non-immersive virtual reality in patients following cerebrovascular incidents and their efficacy in achieving dynamic and static balance. (2) Data sources: An electronic search of the databases Medline, Cochrane Library, PEDro, Scopus, and Scielo from January 2010 to December 2020 was carried out using the terms physiotherapy, physical therapy, virtual reality, immersive virtual reality, non-immersive virtual reality, stroke, balance, static balance, and dynamic balance. Selection of studies: Randomized controlled trials in patients older than 18 developed with an adult population (>18 years old) with balance disorders as a consequence of suffering a stroke in the previous six months before therapeutic intervention, including exercises harnessing virtual reality in their interventions and evaluations of balance and published in English or Spanish, were included. A total of two hundred twenty-seven articles were found, ten of which were included for review and of these, nine were included in the subsequent meta-analysis. (3) Data extraction: Two authors selected the studies and extracted their characteristics (participants, interventions, and validation instruments) and results. The methodological quality of the studies was evaluated using the PEDro scale, and the risk of bias was determined using the Cochrane risk-of-bias tool. Data synthesis: Of the selected studies, three did not show significant improvements and seven showed significant improvements in the intervention groups in relation to the variables. (4) Conclusions: Non-immersive virtual reality combined with conventional rehabilitation could be considered as a therapeutic option. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Incidence of Hypertension in a Cohort of Spanish University Graduates:The SUN Study

Hypertension is a major public health problem. However, no estimates of age- and sex-specific incidences are available for the Spanish population. Our objective was to estimate the incidence of hypertension in a cohort of university graduates in Spain. We followed up 5648 individuals aged 25-65 years who were initially free of hypertension, diabetes, and cardiovascular disease for a median of 30 months. New diagnoses of hypertension were identified using mailed questionnaires. We validated the self-reported diagnosis of hypertension. In 18 250 person-years of follow-up, we identified 248 new cases of hypertension. The unadjusted incidences of hypertension in women and men were 8.2 per 1000 person-years (95% CI, 6.7-10.1) and 21.8 per 1000 person-years (95% CI, 18.6-25.4), respectively. The cumulative probability of receiving a medical diagnosis of hypertension by the age of 65 years was 50% among women and 72% among men. In conclusion, we have provided new evidence confirming that hypertension is one of the most important public health problems in Spain

Revealing hidden clonal complexity in Mycobacterium tuberculosis infection by qualitative and quantitative improvement of sampling

AbstractThe analysis of microevolution events, its functional relevance and impact on molecular epidemiology strategies, constitutes one of the most challenging aspects of the study of clonal complexity in infection by Mycobacterium tuberculosis. In this study, we retrospectively evaluated whether two improved sampling schemes could provide access to the clonal complexity that is undetected by the current standards (analysis of one isolate from one sputum). We evaluated in 48 patients the analysis by mycobacterial interspersed repetitive unit–variable number tandem repeat of M. tuberculosis isolates cultured from bronchial aspirate (BAS) or bronchoalveolar lavage (BAL) and, in another 16 cases, the analysis of a higher number of isolates from independent sputum samples. Analysis of the isolates from BAS/BAL specimens revealed clonal complexity in a very high proportion of cases (5/48); in most of these cases, complexity was not detected when the isolates from sputum samples were analysed. Systematic analysis of isolates from multiple sputum samples also improved the detection of clonal complexity. We found coexisting clonal variants in two of 16 cases that would have gone undetected in the analysis of the isolate from a single sputum specimen. Our results suggest that analysis of isolates from BAS/BAL specimens is highly efficient for recording the true clonal composition of M. tuberculosis in the lungs. When these samples are not available, we recommend increasing the number of isolates from independent sputum specimens, because they might not harbour the same pool of bacteria. Our data suggest that the degree of clonal complexity in tuberculosis has been underestimated because of the deficiencies inherent in a simplified procedure

Prion Protein Gene Variability in Spanish Goats. Inference through Susceptibility to Classical Scrapie Strains and Pathogenic Distribution of Peripheral PrPsc

Classical scrapie is a neurological disorder of the central nervous system (CNS) characterized by the accumulation of an abnormal, partially protease resistant prion protein (PrPsc) in the CNS and in some peripheral tissues in domestic small ruminants. Whereas the pathological changes and genetic susceptibility of ovine scrapie are well known, caprine scrapie has been less well studied. We report here a pathological study of 13 scrapie-affected goats diagnosed in Spain during the last 9 years. We used immunohistochemical and biochemical techniques to discriminate between classical and atypical scrapie and bovine spongiform encephalopathy (BSE). All the animals displayed PrPsc distribution patterns and western blot characteristics compatible with classical scrapie. In addition, we determined the complete open reading frame sequence of the PRNP in these scrapie-affected animals. The polymorphisms observed were compared with those of the herd mates (n¿=¿665) and with the frequencies of healthy herds (n¿=¿581) of native Spanish goats (Retinta, Pirenaica and Moncaina) and other worldwide breeds reared in Spain (Saanen, Alpine and crossbreed). In total, sixteen polymorphic sites were identified, including the known amino acid substitutions at codons G37V, G127S, M137I, I142M, H143R, R151H, R154H, R211Q, Q222K, G232W, and P240S, and new polymorphisms at codons G74D, M112T, R139S, L141F and Q215R. In addition, the known 42, 138 and 179 silent mutations were detected, and one new one is reported at codon 122. The genetic differences observed in the population studied have been attributed to breed and most of the novel polymorphic codons show frequencies lower than 5%. This work provides the first basis of polymorphic distribution of PRNP in native and worldwide goat breeds reared in Spain

OTELO survey: Deep BVRI broad-band photometry of the Groth strip

Context. The Groth field is one of the sky regions that will be targeted by the OTELO (OSIRIS Tunable Filter Emission Line Object) survey in the optical 820 nm and 920 nm atmospheric windows. A complementary broad-band photometric catalogue of the field is essential for several purposes, in particular the inequivocal identification of sources, photometric redshift estimation, and population synthesis fitting.Aims. We aim to describe the OTELO survey and present deep BVRI imaging data of the Groth field. Galaxy number counts, colour distributions and galaxy clustering are analysed.Methods. BVRI deep images (?8 ks) were obtained with the Prime Focus Camera at the WHT (La Palma) and reduced with the IRAF package. The extraction and photometry of the sources was done with SExtractor software. We analysed the final catalogue to obtain galaxy number counts, as well as galaxy correlation functions as a function of I magnitude and V - I colour. It is also compared with estimations from mock catalogues of the Virgo-Millenium consortium.Results. We find excellent agreement between observed and mock data number counts. We also find evidence of galaxy clustering evolution and strong dependence of the angular correlation function on the V - I observed colour. Our data favour a flattening of the clustering amplitude with median apparent magnitude. The good general agreement between our clustering analysis and the estimates from the mock data is remarkableAcknowledgements. This work was supported by the Spanish Plan Nacional de Astronomía y Astrofísica under grants AYA2005–04149 and AYA2006–2358. We thank the referee for helpful comments that improved the clarity of this paper. The Millennium Simulation databases used in this paper and the web application providing online access to them were constructed as part of the activities of the German Astrophysical Virtual Observatory. IRAF is distributed by the National Optical Astronomy Observatory, which is operated by the Association of Universities for Research in Astronomy (AURA) under cooperative agreement with the National Science Foundation. This publication makes use of data products from the Two Micron All Sky Survey, which is a joint project of the University of Massachusetts and the Infrared Processing and Analysis Center California Institute of Technology, funded by the National Aeronautics and Space Administration and the National Science Foundation

A component-based approximation for trend detection of intense rainfall in the Spanish Mediterranean coast

Rainfall behavior is a fundamental issue in areas with scarce and irregular amounts, such as the Spanish Mediterranean region. We identified 12 spatial patterns that characterized 899 torrential precipitation events (≥150 mm in 24 h) that occurred in the 3,537 rainy precipitation series in the period 1950-2020. Three of these components--eastern and ESE--showed positive and significant trends in their accumulated volumes. We then characterized the mean synoptic causes of the 10 most intense events in each component at both mean sea-level pressure and 500 hPa geopotential height, and also the integrated water-vapor transport between 1,000 and 300 hPa. We found a clear spatial distribution of the pluviometric effects related to unstable atmospheric situations (such as troughs and cut-off lows), and also to SW-SE advection fluxes that brought moist air from the Western Mediterranean. In particular, torrential rainfall in the Balearic Islands related more to E-NE advections than to southeastern ones. We also determined that the major parts of these components occurred in early autumn, especially in September and October. We expect these findings to help our understanding of the processes leading to catastrophic situations along the Spanish Mediterranean coast and to lead to improvements in early alert systems and management plans