Monte Carlo simulation of the treatment of uveal melanoma using measured heterogeneous 106Ru plaques

Background/Aims: Ruthenium plaques are used for the treatment of ocular tumors. The aim of this work is the comparison between simulated absorbed dose distributions tallied in an anthropomorphic phantom, obtained from ideal homogeneous plaques, and real eye plaques in which the actual heterogeneous distribution of 106Ru was measured. The placement of the plaques with respect to the tumor location was taken into consideration to optimize the effectiveness of the treatment. Methods: The generic CCA and CCB, and the specific CCA1364 and CCB1256 106Ru eye plaques were modeled with the Monte Carlo code PENELOPE. To compare the suitability of each treatment for an anterior, equatorial and posterior tumor location, cumulative dose-volume histograms for the tumors and structures at risk were calculated. Results: Eccentric placements of the plaques, taking into account the inhomogeneities of the emitter map, can substantially reduce the dose delivered to structures at risk while maintaining the prescribed dose at the tumor apex. Conclusions: The emitter map distribution of the plaque and the computerized tomography of the patient used in a Monte Carlo simulation allow an accurate determination of the plaque position with respect to the tumor with the potential to reduce the dose to sensitive structures. © 2018 S. Karger AG, BaselPostprint (published version

Why study synesthesia? What can that teach us about ourselves?

This essay describes the results of the author’s projects of studying synaesthesia in Spain (University of Granada). It outlines several surveys of potential synaesthetes and possible relations of synaesthesia, creativity and types of “sensory representation”/ intelligence. The author provides her own original definition of “natural synaesthesia” as multi-modal thinking actualized through diffuse perception and polyphonic attention. Such an understanding emphasises the importance of constant philosophical reconsideration of synaesthesia and an interdisciplinary approach to researching the phenomenon. One of the major conclusions made in this essay is that synaesthesia is embedded in the multiple and multilevel processes of the unconscious that constitute both thinking and creativity. Which in turn might mean that perception could be explained through synesthesia and not the other way around, with subsequent revision of the theories of cognitive processes in psychology and neurosciences. The described results lay the foundations for the author’s synaesthesia-based applied methodologies in art education that are aimed to raise awareness of unusual perception among potential synaesthetes and enhance holistic creative thinking of the students through the multi-sensory aspects that they can further include into their own projects

Variation propagation of bench vises in multi-stage machining processes

Comunicación presentada a MESIC 2019 8th Manufacturing Engineering Society International Conference (Madrid, 19-21 de Junio de 2019)Variation propagation has been successfully modeled by the Stream of Variation (SoV) approach in multistage machining processes. However, the SoV model basically supports 3-2-1 fixtures based on punctual locators and other workholding systems such as conventional vises are not considered yet. In this paper, the SoV model is expanded to include the fixture- and datum-induced variations on workholding devices such as bench vises. The model derivation is validated through assembly and machining simulations on Computer Aided Design software. The case study analyzed shows an average error of part quality prediction between the SoV model and the CAD simulations of 0.26%

A Model-Driven Approach for Business Process Management

The Business Process Management is a common mechanism recommended by a high number of standards for the management of companies and organizations. In software companies this practice is every day more accepted and companies have to assume it, if they want to be competitive. However, the effective definition of these processes and mainly their maintenance and execution are not always easy tasks. This paper presents an approach based on the Model-Driven paradigm for Business Process Management in software companies. This solution offers a suitable mechanism that was implemented successfully in different companies with a tool case named NDTQ-Framework.Ministerio de Educación y Ciencia TIN2010-20057-C03-02Junta de Andalucía TIC-578

Dynamic Kinetic Resolution of Hetero biaryl Ketones by Zinc- Catalyzed Asymmetr ic Hydrosil ylation

Adiastereo- and highly enantioselective dynamic kinetic resolution (DKR) of configurationally labile hetero- biaryl ketones is described. The DKR proceeds by zinc- catalyze dhydrosilylation of the carbonyl group ,thus leading to secondary alcohols bearing axial and central chirality .The strategy relies on the labilization of the stereogenic axis that takes place thanks to aLewis acid–base interaction between anitrogen atom in the heterocycle and the ketone carbonyl group .The synthetic utility of the methodology is demonstrated through stereospecific transformations into either N,N-ligands or appealing axially chiral, bifunctional thiourea organocata- lysts.Ministerio de Ciencia e Innovación (Grants CTQ2016-76908-C2-1-P, CTQ2016-76908-C2-2-P, contract RYC-2013-12585)European FEDER FundsJunta de Andalucía (Grant 2012/FQM 10787)European Union - Marie Skłodowska-Curie (COFUND—Grant Agreement n 8 8 291780

La contribución de la psicologia social al estudio de la ciencia

El articulo pretende mostrar la contribución que hasta ahora ha hecho la psicologia social al estudio de la ciencia, señalando sus principales carencias así como las posibles vias de superación de las mismas. Para ello, en prinzer lugar, los autores hacen una propuesta de clasificación temática de los trabajos realizados en el campo de la psicologia social de la ciencia. En segundo lugar, se señala la carencia de una perspectiva más social en este campo y se muestra como los psicólogos sociales críticos han tenido que recurrir a la sociologia para encontrar formulaciones sobre la ciencia y el conociemiento que les sean útiles. Finalmente, se exploran algunos de los aspectos que deberian ser tenidos en cuenta por una psicologia social que superara loss inconvenientes de la psicologia social de la ciencia más clásica. A la primera los autores la denominan psicologia social del conocimiento científicoThis paper presents the contributions of social psychology to the study of science. It highlights its weakerpoints, and suggests ways of overcoming them. First, the authors propose a thematic classification of the studies carried out in the field of social psychology. Second, they stress the need for a more social approach to the discipline. They explain how critical social psychologists have had to turn to sociolog)~to find useful tools to conceptualize science and knowledge. Finally: the article explores some of the aspects that should be considered by a socialpsychology that transcends the problems arising from the discipline's classical approach to science. The authors name their proposa1 "the social psychology of scientific knowledge

Incorporation of form deviations into the matrix transformation method for tolerance analysis in assemblies

Comunicación presentada a MESIC 2019 8th Manufacturing Engineering Society International Conference (Madrid, 19-21 de Junio de 2019)Mathematical models for tolerance representation are used to assess how the geometrical variation of a specific component feature propagates along the assembly, so that tolerance analysis in assemblies can be carried out using a specific tolerance propagation method. Several methods for tolerance analysis have been proposed in the literature, being some of them implemented in CAD systems. All these methods require modelling the geometrical variations of the component surfaces: parametric models, variational models, DoF models, etc. One of the most commonly used models is the DoF model, which is employed in a number of tolerance analysis methods: Small Displacement Torsor (SDT), Technologically and Topologically Related Surfaces (TTRS), Matrix Transformation, Unified Jacobian–Torsor model. However, none of the DoF-based tolerance analysis methods incorporates the effect of form deviations. Among the non DoF-based methods, there are two that include form tolerances: the Vector Loop or Kinematic method and the Tolerance Map (T-Map) model, although the latter is still under development. In this work, a proposal to incorporate form deviations into the matrix transformation method for tolerance analysis in assemblies is developed using a geometrical variation model based on the DoF model. The proposal is evaluated applying it to a 2D case study with components that only have flat surfaces, but the proposal can be extrapolated to 3D cases