Pull From the Knee: Proper Technique and Application

The pull from the knee is a weightlifting movement derivative that can be used in the teaching progression of the clean and snatch exercises. This exercise emphasizes positional strength during the transition phase and the triple extension of the hip, knee, and ankle joints that is characteristic of weightlifting movements

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 Lewy body dementia (LBD) patients, and 3,158 neurologically healthy subjects. Pathogenic expansions (range, 40-64 CAG repeats) in the huntingtin (HTT) gene were found in three (0.12%) patients diagnosed with pure FTD/ALS syndromes but were not present in the LBD or healthy cohorts. We replicated our findings in an independent collection of 3,674 FTD/ALS patients. Postmortem evaluations of two patients revealed the classical TDP-43 pathology of FTD/ALS, as well as huntingtin-positive, ubiquitin-positive aggregates in the frontal cortex. The neostriatal atrophy that pathologically defines Huntington's disease was absent in both cases. Our findings reveal an etiological relationship between HTT repeat expansions and FTD/ALS syndromes and indicate that genetic screening of FTD/ALS patients for HTT repeat expansions should be considered

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

The Power Clean and Power Snatch from the Knee

THE POWER CLEAN AND POWER SNATCH FROM THE KNEE CAN BE USED IN THE TEACHING PROGRESSION OF THE CLEAN AND SNATCH EXERCISES BECAUSE THEY EMPHASIZE POSITIONAL STRENGTH DURING THE TRANSITION PHASE, USE THE DOUBLE KNEE BEND TECHNIQUE, AND TRAIN THE TRIPLE EXTENSION OF THE HIP, KNEE, AND ANKLE JOINTS

The Clean Pull and Snatch Pull: Proper Technique for Weightlifting Movement Derivatives

The clean pull and snatch pull are exercises that use the double knee bend and triple extension involved in weightlifting movements. As a result, these pulling movements are used with the purpose of making an athlete more efficient at producing force with an overload stimulus. In addition, these exercises can be used as a teaching modality for the progressive development of the full clean or snatch

The Pull to Knee-Proper Biomechanics for a Weightlifting Movement Derivative

The pull to knee is an exercise that allows an athlete to become efficient in producing force with an overload stimulus, as well as it is a teaching modality for the initial pull from the floor in weightlifting. This movement emphasizes the precursor movement leading into the double knee bend position

The Jump Shrug: A Progressive Exercise Into Weightlifting Derivatives

The jump shrug is a weightlifting movement derivative that can be used to teach the clean and snatch exercises or as a stand-alone training exercise. The ballistic nature of this exercise allows athletes to produce high amounts of lower extremity power, an essential component to athletic performance

The Hang High Pull: A Progressive Exercise Into Weightlifting Derivatives

The hang high pull is a weightlifting movement derivative that can be used in the teaching progression of the clean and snatch exercises. This exercise elicits high amounts of lower-body power within the second pull of the movement by emphasizing the extension of the hip, knee, and ankle joints

Pull From the Knee: Proper Technique and Application

The pull from the knee is a weightlifting movement derivative that can be used in the teaching progression of the clean and snatch exercises. This exercise emphasizes positional strength during the transition phase and the triple extension of the hip, knee, and ankle joints that is characteristic of weightlifting movements