INVESTIGATING THE EFFECT OF TURKISH TOURISM SECTOR'S GROWTH INDICATORS ON THE FINANCIAL PERFORMANCE OF TOURISM COMPANIES

Bu çalışmanın amacı, turizm sektöründeki büyümenin turizm işletmelerinin finansal performanslarına olan etkilerinin incelenmesidir. Bu bağlamda; turizm gelirlerinin milli gelire oranı ve turizm işletmelerinin doluluk oranındaki gelişmeler ile Türk turizm işletmelerinin finansal performansları arasındaki ilişki incelenmiştir. Finansal performans, Yatırım Karlılığı, Özsermaye Karlılığı ve Satışların Karlılığı ile ölçülmüştür. Sonuçlar, Türk turizm işletmelerinin doluluk oranları ile finansal performansları arasında doğru yönde bir ilişki olduğunu göstermiştir. Öte yandan, üç performans ölçütü ile turizm gelirlerinin milli gelire oranı arasındaki ilişki negatif yönlü olarak saptanmıştır. Ayrıca, 1994 ve 2001 yıllarında yaşanan ekonomik krizlerin turizm işletmelerinin performanslarını olumsuz etkilediği belirlenmiştir. Aim of this study is to investigate the effects of tourism sector growth on the financial performance of Turkish tourism companies. In this context, the relationship among the innovation in the ratio of tourism revenues to national income, occupancy rates and financial performances of tourism companies is investigated. Financial performance is measured by return on assets, return on equity and return on sales. Results suggest that there exists a positive relationship among occupancy rates of tourism companies and their financial performances. On the other hand, a negative relationship is observed among the financial performance measures and the ratio of tourism revenues to national income. Furthermore, economic crises of 1994 and 2001 seem to affect financial performances of tourism companies negatively

Clinical Characteristics and Visual Outcomes of Pediatric Optic Neuritis: A Single Center Experience

INTRODUCTION: The aim of this study was to describe the clinical characteristics, visual outcomes of pediatric patients presenting with first-episode of optic neuritis. METHODS: We reviewed medical records of the patients newly diagnosed with optic neuritis younger than 18 years between January 2014 and December 2018 retrospectively. RESULTS: Twenty-eight patients were included to this study. The mean age at first onset of optic neuritis was 13.2+-3.1 years (range 6.2-17.3 years). The mean follow-up period was 4.2+-3.2 (range 0.6-13.08) years. 7 of 28 (25%) patients had recurrent optic neuritis. Optic neuritis involvement was unilateral in 17 of 28 (60%) patients. Forty percent of the patients had idiopathic optic neuritis. Of the six patients with demyelinating lesions in cranial magnetic resonance imaging (MRI) at the first admission, three were diagnosed with multiple sclerosis (MS) at the time of first optic neuritis attack, and three were diagnosed within 13.4+-4.8 months after the first episode. Eight of 21 optic neuritis patients (38%) had oligoclonal band positivity and the incidence of MS was significantly higher in these patients (p=0.014). The mean visual acuity at nadir was 0.48+-0.27 at admission. Whereas it was 0.74+-0.31 and 0.76+-0.33 at 1 and 6 months respectively. There was a strong correlation between first and sixth-month visual acuity (r=0.98, p=0.00). DISCUSSION AND CONCLUSION: Our study demonstrated that poor visual acuity (worse than 0.5) at 1 month can predict poor vision at 6 months. The patients with demyelinating lesions in cranial MRI at their first optic neuritis episode, are more likely to develop MS during the follow-up

Survival results according to Oncotype Dx recurrence score in patients with hormone receptor positive HER-2 negative early-stage breast cancer: first multicenter Oncotype Dx recurrence score survival data of Turkey

BackgroundThe Oncotype Dx recurrence score (ODx-RS) guides the adjuvant chemotherapy decision-making process for patients with early-stage hormone receptor-positive, HER-2 receptor-negative breast cancer. This study aimed to evaluate survival and its correlation with ODx-RS in pT1-2, N0-N1mic patients treated with adjuvant therapy based on tumor board decisions.Patients and methodsEstrogen-positive HER-2 negative early-stage breast cancer patients (pT1-2 N0, N1mic) with known ODx-RS, operated on between 2010 and 2014, were included in this study. The primary aim was to evaluate 5-year disease-free survival (DFS) rates according to ODX-RS.ResultsA total of 203 eligible patients were included in the study, with a median age of 48 (range 26-75) and median follow-up of 84 (range 23-138) months. ROC curve analysis for all patients revealed a recurrence cut-off age of 45 years, prompting evaluation by grouping patients as ≤45 years vs. >45 years. No significant difference in five-year DFS rates was observed between the endocrine-only (ET) and chemo-endocrine (CE) groups. However, among the ET group, DFS was higher in patients over 45 years compared to those aged ≤45 years. When stratifying by ODx-RS as 0-17 and ≥18, DFS was significantly higher in the former group within the ET group. However, such differences were not seen in the CE group. In the ET group, an ODx-RS ≥18 and menopausal status were identified as independent factors affecting survival, with only an ODx-RS ≥18 impacting DFS in patients aged ≤45 years. The ROC curve analysis for this subgroup found the ODx-RS cut-off to be 18.ConclusionThis first multicenter Oncotype Dx survival analysis in Turkey demonstrates the importance of Oncotype Dx recurrence score and age in determining treatment strategies for early-stage breast cancer patients. As a different aproach to the literature, our findings suggest that the addition of chemotherapy to endocrine therapy in young patients (≤45 years) with Oncotype Dx recurrence scores of ≥18 improves DFS

Aiders of Atatürk

Yaverler, yaverliğini yapmış olduğu kişinin resmi ve özel işlerinin birinci dereceden tanığıdır. Görev yaptıkları dönemde amirinin ihtiyaçları, güvenliği, talep ve emirlerini gerçekleştirmek gibi önemli bir hizmet içerisindeyken görevleri sonunda da o dönemin birinci dereceden kaynağı olma yükümlülüğü içerisinde olmuşlardır. Şüphesiz ki Türk tarihinde hiçbir yaver Mustafa Kemal’in yaverleri kadar önemli olmamıştır. Onları önemli kılan ise bir devletin kurulması ve liderlerinin yapmış olduğu inkılapların safha safha şahidi olmalarıdır. Bu çalışmadaki amacımız böyle önemli bir görevi ifa etmiş olan kişilerin askeri ve özel yaşamlarını, şahsiyetlerini kısaca biyografilerini ve Mustafa Kemal ATATÜRK’le beraber yaşamış veya şahit oldukları hatıraları ele almaktır.The aiders are the witnesses of the people of whom they help with their formal and private works. While they were holding a special service in order to accomplish the safety, necessities demans and orders of their chiefs, at the end of their duties they were responsible for being the witnesses of their period. There is no doubt that any aiders weren’t as important as Mustafa Kemal’s aiders in the Turkish history. What makes them important is that they became the witnesses of the period in which the republic was founded and the period in which the revolution took place. Our aim in this research is to consider the military and special life ot such important people, their personalities, shortly their biogrophies and their memories with Mustafa Kemal ATATÜRK

Aiders of Atatürk

Yaverler, yaverliğini yapmış olduğu kişinin resmi ve özel işlerinin birinci dereceden tanığıdır. Görev yaptıkları dönemde amirinin ihtiyaçları, güvenliği, talep ve emirlerini gerçekleştirmek gibi önemli bir hizmet içerisindeyken görevleri sonunda da o dönemin birinci dereceden kaynağı olma yükümlülüğü içerisinde olmuşlardır. Şüphesiz ki Türk tarihinde hiçbir yaver Mustafa Kemal’in yaverleri kadar önemli olmamıştır. Onları önemli kılan ise bir devletin kurulması ve liderlerinin yapmış olduğu inkılapların safha safha şahidi olmalarıdır. Bu çalışmadaki amacımız böyle önemli bir görevi ifa etmiş olan kişilerin askeri ve özel yaşamlarını, şahsiyetlerini kısaca biyografilerini ve Mustafa Kemal ATATÜRK’le beraber yaşamış veya şahit oldukları hatıraları ele almaktır.The aiders are the witnesses of the people of whom they help with their formal and private works. While they were holding a special service in order to accomplish the safety, necessities demans and orders of their chiefs, at the end of their duties they were responsible for being the witnesses of their period. There is no doubt that any aiders weren’t as important as Mustafa Kemal’s aiders in the Turkish history. What makes them important is that they became the witnesses of the period in which the republic was founded and the period in which the revolution took place. Our aim in this research is to consider the military and special life ot such important people, their personalities, shortly their biogrophies and their memories with Mustafa Kemal ATATÜRK

An Unusual Cause of the Transient Osteoporosis of the Femoral Head: Essential Thrombocytosis

Introduction:Transient osteoporosis(TO), also known as bone marrow edema syndrome, is characterized by marrow edema which causes increasing of intramedullary pressure. Among the other causes, such as 3rdthird-trimester pregnancy, impaired circulation may also be caused by changes in normal blood counts such as thrombocytosis. There are multiple reports in the literature of secondary femoral head TO transient osteoporosis; however, there is no case report of femoral head TO transient osteoporos is specifically secondary to essential thrombocytosis (ET) in literature. Herein, we present ET essential thrombocytosisas an unusual cause of TO transientosteoporosis of the femoral head.Case report:A 33-year-old male presented himself to our clinic with severe left hip pain. The patient has painful hip motions and itching after the bath and episodic chest pain. Family history is positive for hematological malignancy. Complete blood count (CBC)test showed an increased level of thyrombocytes and haematology opinion obtained. The genetic analysis was positive for Janus kinase 2JAK2V617F and patient was diagnonsed as ET essential thrombocytosis. Besides, to eliminate the symptoms of the hip, the surgical intervention had planned and the patient had a dramatic pain relief during follow-up.Conclusion:ET Essential thrombocytosisis a myeloproliferative disorder and has a good prognosis. TOTransient osteoporosis could be accompanied with hematologic disorders, especially myeloproliferative diseases. Based on our review of literature, this is the first case with ETessential thrombocytosis and TO transient osteoporosis of the hip

Microbiological and chemical quality of tahini halva

Purpose - This paper aims to determine the microbiological and chemical quality of halva samples obtained from retail markets and producers in the Marmara region

INVESTIGATING THE EFFECT OF TURKISH TOURISM SECTOR'S GROWTH INDICATORS ON THE FINANCIAL PERFORMANCE OF TOURISM COMPANIES

Bu çalısmanın amacı, turizm sektöründeki büyümenin turizm isletmelerinin finansal performanslarına olan etkilerinin incelenmesidir. Bu bağlamda; turizm gelirlerinin milli gelire oranı ve turizm isletmelerinin doluluk oranındaki gelismeler ile Türk turizm isletmelerinin finansal performansları arasındaki iliski incelenmistir. Finansal performans, Yatırım Karlılığı, Özsermaye Karlılığı ve Satısların Karlılığı ile ölçülmüstür. Sonuçlar, Türk turizm isletmelerinin doluluk oranları ile finansal performansları arasında doğru yönde bir iliski olduğunu göstermistir. Öte yandan, üç performans ölçütü ile turizm gelirlerinin milli gelire oranı arasındaki iliski negatif yönlü olarak saptanmıstır. Ayrıca, 1994 ve 2001 yıllarında yasanan ekonomik krizlerin turizm isletmelerinin performanslarını olumsuz etkilediği belirlenmistir. Aim of this study is to investigate the effects of tourism sector growth on the financial performance of Turkish tourism companies. In this context, the relationship among the innovation in the ratio of tourism revenues to national income, occupancy rates and financial performances of tourism companies is investigated. Financial performance is measured by return on assets, return on equity and return on sales. Results suggest that there exists a positive relationship among occupancy rates of tourism companies and their financial performances. On the other hand, a negative relationship is observed among the financial performance measures and the ratio of tourism revenues to national income. Furthermore, economic crises of 1994 and 2001 seem to affect financial performances of tourism companies negatively

Rare congenital retinal vascular anomalies

Amaç: Konjenital retina damar anomalisi (KRDA) olan hastaların klinik ve demografik bulgularını tanımlamak ve ayırıcı tanıda kullanılan karakteristik özelliklerini gözden geçirmektir. Gereç ve Yöntem: Kliniğimizde KRDA tespit edilen hastalar detaylı oftalmolojik muayene, renkli fundus fotografisi ve floresein anjiografi ile değerlendirildi, eşlik eden sistemik hastalıklar açısından araştırıldı. Bulgular: Toplam 15 hastanın 25 gözünde sistemik araştırmaları tamamlanmış KRDA saptandı ve çalışma kapsamına alındı. Beş hastada konjenital retina arter tortuositesi, 4 hastada prepapiller vasküler halka, 1 hastada maküler makrodamar, 5 hastada idiopatik genel tortuosite tespit edildi. İdiopatik genel tortuosite görülen bir hastada saptanan ven dal tıkanıklığı ve konjenital arter tortuositesi olan bir hastadaki bilateral makülopati haricinde hastaların hiçbirinde görülen bu anomalilerle ilişkilendirilebilecek bir komplikasyon izlenmedi. Sonuç: Konjenital retina arter tortuositesi, prepapiller vasküler halka, maküler makrodamar ve idiopatik genel vasküler tortuosite genellikle iyi seyirli, nadiren komplikasyona yol açan konjenital retina damar anomalilerindendir. Bunların benzer tablolara yol açan sistemik ve oküler hastalıklardan ayırıcı tanısının yapılması bu hastaların takip ve tedavisinde yararlı olacaktır.Purpose: To define clinical and demographic findings of congenital retinal vascular anomalies and to review the characteristic signs useful to make differential diagnosis. Materials and Methods: Cases with detected congenital retinal vascular anomalies were evaluated via detailed ophthalmic examination, fundus photography, flouresceine angiography and also associated systemic diseases were investigated. Results: The study comprised 25 eyes of 15 patients with congenital retinal vascular anomalies that had complete systemic examinations. Congenital retinal arterial tortuosity was found in 5 cases, prepapillary vascular loops was observed in 4 eyes, macular macro-vessel was discovered in 1 eye, idiopathic generalized tortuosity was detected in 5 cases. No complications that could be pertained to vascular anomalies was observed except two patients in whom one eye with idiopathic generalized tortuosity had associated branch retinal vein occlusion and both eyes of a patient with bilateral congenital retinal arterial tortuosity was accompanied by maculopathy. Conclusion: Congenital retinal arterial tortuosity, prepapillary vascular loops, macular macro-vessels and idiopathic generalized tortuosity are among congenital retinal vascular anomalies that have favorable prognosis and infrequent complications. Differentiating these anomalies from systemic and ocular conditions that may lead to similar findings is useful in diagnosis and follow-up of these patients