Rol enfermero en la prevención y el manejo de la complicaciones de la tiroidectomía

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Desarrollo de una aplicación ITS: detección de colisión

The project presented in this paper deals with the creation of a C-ITS application, a technology that wirelessly communicates terrestrial transports, to warn of possible collisions with other vehicles. It is a first version of an application that uses existing standards and open code programs that implement it. As a result it have been obtained an application that works correctly in some scenarios but that has to improve the performance of time to implement it in the real world.El proyecto presentado en este trabajo trata la creación de una aplicación C-ITS, tecnología que comunica inalámbricamente los transportes terrestres, para avisar de posibles colisiones con otros vehículos. Es una primera versión de una aplicación que utiliza estándares existentes y programas de código libre que lo implementan. Como resultado se ha obtenido una aplicación que funciona correctamente en algunos escenarios pero que ha de mejorar las prestaciones de tiempo para implementarlo en el mundo real.El projecte presentat en aquest treball tracta la creació d'una aplicació C-ITS, tecnologia que comunica sense fils els transports terrestres, per avisar de posibles colisions amb altres vehicles. És una primera versió d'una aplicación que utilitza estandards existents i programes de codi lliure que ho implementen. Com a resultat s'ha obtingut una aplicació que funciona correctament en alguns escenaris però que ha de millorar les prestacions de temps per implementar-ho en el món real

SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression

Breast cancer remains a significant female mortality cause. It constitutes a multifactorial disease for which research on environmental factors offers little help in predicting onset or progression. The pursuit for its foundations by analyzing hormonal changes as a motive for disease development, indicates that increased exposure to estrogens associates with increased risk. A prevalent number of breast cancer cases show dependence on the increased activity of the classic nuclear estrogen receptor (ER) for cell proliferation and survival. SIRT1 is a Type III histone deacetylase which is receiving increasing attention due to its ability to perform activities over relevant non-histone proteins and transcription factors. Interestingly, concomitant SIRT1 overexpression is commonly found in ER-positive breast cancer cases. Both proteins had been shown to directly interact, in a process related to altered intracellular signaling and aberrant transcription, then promoting tumor progression. Moreover, SIRT1 activities had been also linked to estrogenic effects through interaction with the G-protein coupled membrane bound estrogen receptor (GPER). This work aims to summarize present knowledge on the interplay between SIRT1 and ER/GPER for breast cancer onset and progression. Lastly, evidences on the ability of SIRT1 to interact with TGFß signaling, a concurrent pathway significantly involved in breast cancer progression, are reported. The potential of this research field for the development of innovative strategies in the assessment of orphan breast cancer subtypes, such as triple negative breast cancer (TNBC), is discussed

Cimetidine disrupts the renewal of testicular cells and the steroidogenesis in a hermaphrodite fish

The importance of histamine in the physiology of the testis in mammals and reptiles has been recently shown. Histamine receptors (Hrs) are well conserved in fish and are functional in several fish species. We report here for the first time that histamine and the mRNA of Hrh1, Hrh2 and Hrh3 are all present in the gonad of the hermaphrodite teleost fish gilthead seabream. Moreover, cimetidine, which acts in vitro as an agonist of Hrh1 and Hrh2 on this species, was intraperitoneally injected in one and two years old gilthead seabream males. After three and five days of cimetidine injection, we found that this compound differently modified the gonadal hrs transcript levels and affects the testicular cell renewal and the gene expression of steroidogenesis-related molecules as well as the serum steroid levels. Our data point to cimetidine as a reproductive disruptor and elucidate a role for histamine in the gonad of this hermaphrodite fish species through Hr signalling.Postprint2,616

Perinatal derivatives: How to best characterize their multimodal functions in vitro. Part C: Inflammation, angiogenesis, and wound healing

Perinatal derivatives (PnD) are birth-associated tissues, such as placenta, umbilical cord, amniotic and chorionic membrane, and thereof-derived cells as well as secretomes. PnD play an increasing therapeutic role with beneficial effects on the treatment of various diseases. The aim of this review is to elucidate the modes of action of non-hematopoietic PnD on inflammation, angiogenesis and wound healing. We describe the source and type of PnD with a special focus on their effects on inflammation and immune response, on vascular function as well as on cutaneous and oral wound healing, which is a complex process that comprises hemostasis, inflammation, proliferation (including epithelialization, angiogenesis), and remodeling. We further evaluate the different in vitro assays currently used for assessing selected functional and therapeutic PnD properties. This review is a joint effort from the COST SPRINT Action (CA17116) with the intention to promote PnD into the clinics. It is part of a quadrinomial series on functional assays for validation of PnD, spanning biological functions, such as immunomodulation, anti-microbial/anti-cancer activities, anti-inflammation, wound healing, angiogenesis, and regeneration

Chiral seeded growth of gold nanorods into fourfold twisted nanoparticles with plasmonic optical activity

A robust and reproducible methodology to prepare stable inorganic nanoparticles with chiral morphology may hold the key to the practical utilization of these materials. An optimized chiral growth method to prepare fourfold twisted gold nanorods is described herein, where the amino acid cysteine is used as a dissymmetry inducer. Four tilted ridges are found to develop on the surface of single-crystal nanorods upon repeated reduction of HAuCl4, in the presence of cysteine as the chiral inducer and ascorbic acid as a reducing agent. From detailed electron microscopy analysis of the crystallographic structures, it is proposed that the dissymmetry results from the development of chiral facets in the form of protrusions (tilted ridges) on the initial nanorods, eventually leading to a twisted shape. The role of cysteine is attributed to assisting enantioselective facet evolution, which is supported by density functional theory simulations of the surface energies, modified upon adsorption of the chiral molecule. The development of R-type and S-type chiral structures (small facets, terraces, or kinks) would thus be non-equal, removing the mirror symmetry of the Au NR and in turn resulting in a markedly chiral morphology with high plasmonic optical activity.Agencia Estatal de Investigación | Ref. PID2019-108954RB-I00Agencia Estatal de Investigación | Ref. PID2020-117371RA-I00Agencia Estatal de Investigación | Ref. PID2020-117779RB-I00Agencia Estatal de Investigación | Ref. MDM-2017-0720Xunta de Galicia | Ref. ED431C 2020/09Agencia Estatal de Investigación | Ref. RTI2018-101394-B-I00Agencia Estatal de Investigación | Ref. PID2021-122516OB-I00Agencia Estatal de Investigación | Ref. CEX2019-000925-SAlexander von Humboldt FoundationDeutsche ForschungsgemeinschaftNational Natural Science Foundation (China

Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study

IntroductionSecond-generation integrase strand transfer inhibitors (INSTIs) are preferred treatment options worldwide, and dolutegravir (DTG) is the treatment of choice in resource-limited settings. Nevertheless, in some resource-limited settings, these drugs are not always available. An analysis of the experience with the use of INSTIs in unselected adults living with HIV may be of help to make therapeutic decisions when second-generation INSTIs are not available. This study aimed to evaluate the real-life effectiveness and safety of dolutegravir (DTG), elvitegravir/cobicistat (EVG/c), and raltegravir (RAL) in a large Spanish cohort of HIV-1-infected patients.MethodsReal-world study of adults living with HIV who initiated integrase INSTIs DTG, EVG/c, and RAL-based regimens in three settings (ART-naïve patients, ART-switching, and ART-salvage patients). The primary endpoint was the median time to treatment discontinuation after INSTI-based regimen initiation. Proportion of patients experiencing virological failure (VF) (defined as two consecutive viral loads (VL) ≥200 copies/mL at 24 weeks or as a single determination of VL ≥1,000 copies/mL while receiving DTG, EVG/c or RAL, and at least 3 months after INSTI initiation) and time to VF were also evaluated.ResultsVirological effectiveness of EVG/c- and RAL-based regimens was similar to that of DTG when given as first-line and salvage therapy. Treatment switching for reasons other than virological failure was more frequent in subjects receiving EVG/c and, in particular, RAL. Naïve patients with CD4+ nadir <100 cells/μL were more likely to develop VF, particularly if they initiated RAL or EVG/c. In the ART switching population, initiation of RAL and EVG/c was associated with both VF and INSTI discontinuation. There were no differences in the time to VF and INSTI discontinuation between DTG, EVG/c and RAL. Immunological parameters improved in the three groups and for the three drugs assessed. Safety and tolerability were consistent with expected safety profiles.DiscussionWhereas second-generation INSTIs are preferred treatment options worldwide, and DTG is one of the treatment of choices in resource-limited settings, first-generation INSTIs may still provide high virological and immunological effectiveness when DTG is not available

Desarrollo de una aplicación ITS: detección de colisión

The project presented in this paper deals with the creation of a C-ITS application, a technology that wirelessly communicates terrestrial transports, to warn of possible collisions with other vehicles. It is a first version of an application that uses existing standards and open code programs that implement it. As a result it have been obtained an application that works correctly in some scenarios but that has to improve the performance of time to implement it in the real world.El proyecto presentado en este trabajo trata la creación de una aplicación C-ITS, tecnología que comunica inalámbricamente los transportes terrestres, para avisar de posibles colisiones con otros vehículos. Es una primera versión de una aplicación que utiliza estándares existentes y programas de código libre que lo implementan. Como resultado se ha obtenido una aplicación que funciona correctamente en algunos escenarios pero que ha de mejorar las prestaciones de tiempo para implementarlo en el mundo real.El projecte presentat en aquest treball tracta la creació d'una aplicació C-ITS, tecnologia que comunica sense fils els transports terrestres, per avisar de posibles colisions amb altres vehicles. És una primera versió d'una aplicación que utilitza estandards existents i programes de codi lliure que ho implementen. Com a resultat s'ha obtingut una aplicació que funciona correctament en alguns escenaris però que ha de millorar les prestacions de temps per implementar-ho en el món real

Desarrollo de una aplicación ITS: detección de colisión

The project presented in this paper deals with the creation of a C-ITS application, a technology that wirelessly communicates terrestrial transports, to warn of possible collisions with other vehicles. It is a first version of an application that uses existing standards and open code programs that implement it. As a result it have been obtained an application that works correctly in some scenarios but that has to improve the performance of time to implement it in the real world.El proyecto presentado en este trabajo trata la creación de una aplicación C-ITS, tecnología que comunica inalámbricamente los transportes terrestres, para avisar de posibles colisiones con otros vehículos. Es una primera versión de una aplicación que utiliza estándares existentes y programas de código libre que lo implementan. Como resultado se ha obtenido una aplicación que funciona correctamente en algunos escenarios pero que ha de mejorar las prestaciones de tiempo para implementarlo en el mundo real.El projecte presentat en aquest treball tracta la creació d'una aplicació C-ITS, tecnologia que comunica sense fils els transports terrestres, per avisar de posibles colisions amb altres vehicles. És una primera versió d'una aplicación que utilitza estandards existents i programes de codi lliure que ho implementen. Com a resultat s'ha obtingut una aplicació que funciona correctament en alguns escenaris però que ha de millorar les prestacions de temps per implementar-ho en el món real

Modulación de la respuesta inmunitaria por hormonas y factores reproductores en teleósteos / Sergio David Liarte Lastra; directores, Alfonsa García Ayala, Elena Chaves Pozo, José Meseguer Peñalver.

Tesis-Universidad de Murcia.MEDICINA ESPINARDO. DEPOSITO. MU-Tesis 866.Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. TM 4265