Development of an adenosquamous carcinoma histopathology - selective lung metastasis model

Peer reviewe

Emerging Escherichia coli O25b/ST131 Clone Predicts Treatment Failure in Urinary Tract Infections

Background. We described the clinical predictive role of emerging Escherichia coli O25b/sequence type 131 (ST131) in treatment failure of urinary tract infection. Methods. In this prospective observational cohort study, the outpatients with acute cystitis with isolation of E. coli in their urine cultures were assessed. All the patients were followed up for clinical cure after 10 days of treatment. Detection of the E. coli O25:H4/ST131 clone was performed by multiplex polymerase chain reaction (PCR) for phylogroup typing and using PCR with primers for O25b rfb and allele 3 of the pabB gene. Results. In a cohort of patients with diagnosis of acute urinary cystitis, 294 patients whose urine cultures were positive with a growth of >10(4) colony-forming units/mL of E. coli were included in the study. In empiric therapy, ciprofloxacin was the first choice of drug (27%), followed by phosphomycin (23%), trimethoprim-sulfamethoxazole (TMP-SMX) (9%), and cefuroxime (7%). The resistance rate was 39% against ciprofloxacin, 44% against TMP-SMX, and 25% against cefuroxime. Thirty-five of 294 (12%) isolates were typed under the O25/ST131 clone. The clinical cure rate was 85% after the treatment. In multivariate analysis, detection of the O25/ST131 clone (odds ratio [ OR], 4; 95% confidence interval [ CI], 1.51-10.93; P = .005) and diabetes mellitus (OR, 2.1; 95% CI,.99-4.79; P = .05) were found to be significant risk factors for the treatment failure. In another multivariate analysis performed among quinolone-resistant isolates, treatment failure was 3 times more common among the patients who were infected with ST131 E. coli (OR, 3; 95% CI, 1.27-7.4; P = .012). Conclusions. In urinary tract infections, the E. coli ST131 clone seems to be a consistent predictor of treatment failure

The Body Mass Index and Related Factors of Aged Living in a District of Istanbul, Turkey

Background: To determine the nutritional status of elderly by body mass index (BMI) and to investigate associated factors. Methods: This is a cross-sectional, descriptive and analytic study done among 309 elderly, in the Besiktas district of Istanbul from January to December 2008. The interviews were performed face-to-face. Anthropometric measurements (height, weight) were taken and BMI was calculated and classified according to World Health Organization standards. Results: According to BMI classification, 1.6% were underweight, 15.2% were normal, 32.4% were overweight, 46.3% were obese and 4.5% were morbidly obese. A gradually lower BMI was observed with the progression of age. According to the study, obesity rates tended to be higher in those with inferior educational background. The study also revealed that diabetes mellitus is more prevalent in those that are overweight, obese and morbidly obese than those that are underweight and normal. In addition, hypertension is a more common ailment along obese and morbidly obese elders. On the contrary, osteoporosis is more prevalent among underweight and normal elders than those that are classified as obese and morbidly obese. Conclusion: BMI provides valuable insight in lieu of nutritional status and health state of the elderly in the primary health care unit

SLEEP DISORDERS DURING OLD AGES AND RELATED FACTORS: THE RESULTS OF THE+65 ACTIVE AGING PROJECT

Introduction: Our purpose was to determine the problems related with sleep quality and continuity, and also to investigate the physical, psychological and some demographic factors that can lead these problems