Competitive potential of trade organization : theoretical and methodological foundations of formation and realization

Problematics of competitive potential of organization does not have any multi-disciplinary limitations of research. Study of competitive potential in connection with factors of its formation and conditions for realization, including competition, competitiveness, and competitive advantages of organization, was conducted by many scientists. At that, in view of sectorial specifics, there is domination of works devoted to study of competitive potential of production, not trade, organizations. Idea of sense, content, and structure of competitive potential, factors and conditions of its dynamics are not characterized by integrity of opinions, which leads to necessity for specification of theoretical aspects of formation of competitive potential. Methodology of study of competitive potential of organization in part of substantiation of evolutional approach and development of methodological tools which ensure its realization in analytical practice requires further development. Trade organizations have a need for concept and tools of development of competitive potential which correspond to modern realia of development of competitive relations in consumers market. These problems on the whole determine hypothesis of research and predetermined formulation of its goal and tasks. The purpose of the research consists in setting and solving scientific problem in the sphere of specification of theoretical aspects of formation of competitive potential in regard to specifics of activities of trade organizations, development of methodology, and methodological provision of its study, concept, and tools of development. In the conducted research, the authors distinguish the main aspects of treatment of competitive potential of organization and perform structuring of competitive potential of trade organization and determined conditions for provision of its dynamics; methodological approaches to study of competitive potential of organization are generalized, and evolutional approach and its methodological instrumentarium are substantiated; factors and conditions of realization of competitive potential of trade organizations are studied. Recommendations, formulated in the article, could be used for solving problems related to creation of new competitive advantages of enterprises and their effective realization.peer-reviewe

Development of a three-level model of early rehabilitation in Perm kray

The article deals with the concept and the content of the technology of early rehabilitation and carries out a retrospective analysis of its development in the Russian Federation and abroad. The authors present the experience of organizing the system of early rehabilitation services in Perm Kray as a three-level model. At the macro-level, the model describes the content and the specificity of realization of the mechanisms of interdepartmental cooperation and highlights the problems and perspectives of their realization. The meso-level deals with the organization of activity of the services of early rehabilitation in institutions of various departments and agencies.В статье представлен опыт организации системы ранней помощи в Пермском крае, сложившейся в виде трехуровневой модели.

Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals

4-Arylhydrazinylidene-5-(polyfluoroalkyl)pyrazol-3-ones (4-AHPs) were found to be obtained by the regiospecific cyclization of 2-arylhydrazinylidene-3-(polyfluoroalkyl)-3-oxoesters with hydrazines, by the azo coupling of 4-nonsubstituted pyrazol-5-oles with aryldiazonium chlorides or by the firstly discovered acid-promoted self-condensation of 2-arylhydrazinylidene-3-oxoesters. All the 4-AHPs had an acceptable ADME profile. Varying the substituents in 4-AHPs promoted the switching or combining of their biological activity. The polyfluoroalkyl residue in 4-AHPs led to the appearance of an anticarboxylesterase action in the micromolar range. An NH-fragment and/or methyl group instead of the polyfluoroalkyl one in the 4-AHPs promoted antioxidant properties in the ABTS, FRAP and ORAC tests, as well as anti-cancer activity against HeLa that was at the Doxorubicin level coupled with lower cytotoxicity against normal human fibroblasts. Some Ph-N-substituted 4-AHPs could inhibit the growth of N. gonorrhoeae bacteria at MIC 0.9 μg/mL. The possibility of using 4-AHPs for cell visualization was shown. Most of the 4-AHPs exhibited a pronounced analgesic effect in a hot plate test in vivo at and above the diclofenac and metamizole levels except for the ones with two chlorine atoms in the aryl group. The methylsulfonyl residue was proved to raise the anti-inflammatory effect also. A mechanism of the antinociceptive action of the 4-AHPs through blocking the TRPV1 receptor was proposed and confirmed using in vitro experiment and molecular docking. © 2022 by the authors.FFSN-2021-0005; Russian Foundation for Basic Research, РФФИ: 20-03-00312; Russian Science Foundation, RSF: 21-13-00390This work was financially supported by the Russian Science Foundation (grant No 21-13-00390 for V.I.S.): the synthesis and analysis of compounds, antimicrobial evaluation, cytotoxicity, analgesic and anti-inflammatory activity, mechanism of analgesia, molecular docking; by the Russian Foundation for Basic Research (grant No 20-03-00312 for Y.V.B.): esterase profile of compounds; antioxidant activity in ABTS and FRAP tests were performed in the frame of IPAC RAS State Targets Project FFSN-2021-0005

Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer’s disease

We investigated the inhibitory activities of novel 9-phosphoryl-9,10-dihydroacridines and 9-phosphorylacridines against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carboxylesterase (CES). We also studied the abilities of the new compounds to interfere with the self-aggregation of β-amyloid (Aβ42) in the thioflavin test as well as their antioxidant activities in the ABTS and FRAP assays. We used molecular docking, molecular dynamics simulations, and quantum-chemical calculations to explain experimental results. All new compounds weakly inhibited AChE and off-target CES. Dihydroacridines with aryl substituents in the phosphoryl moiety inhibited BChE; the most active were the dibenzyloxy derivative 1d and its diphenethyl bioisostere 1e (IC50 = 2.90 ± 0.23 µM and 3.22 ± 0.25 µM, respectively). Only one acridine, 2d, an analog of dihydroacridine, 1d, was an effective BChE inhibitor (IC50 = 6.90 ± 0.55 μM), consistent with docking results. Dihydroacridines inhibited Aβ42 self-aggregation; 1d and 1e were the most active (58.9% ± 4.7% and 46.9% ± 4.2%, respectively). All dihydroacridines 1 demonstrated high ABTS•+-scavenging and iron-reducing activities comparable to Trolox, but acridines 2 were almost inactive. Observed features were well explained by quantum-chemical calculations. ADMET parameters calculated for all compounds predicted favorable intestinal absorption, good blood–brain barrier permeability, and low cardiac toxicity. Overall, the best results were obtained for two dihydroacridine derivatives 1d and 1e with dibenzyloxy and diphenethyl substituents in the phosphoryl moiety. These compounds displayed high inhibition of BChE activity and Aβ42 self-aggregation, high antioxidant activity, and favorable predicted ADMET profiles. Therefore, we consider 1d and 1e as lead compounds for further in-depth studies as potential anti-AD preparations. Copyright © 2023 Makhaeva, Kovaleva, Rudakova, Boltneva, Lushchekina, Astakhova, Timokhina, Serebryakova, Shchepochkin, Averkov, Utepova, Demina, Radchenko, Palyulin, Fisenko, Bachurin, Chupakhin, Charushin and Richardson.122041400110-4; FFSN-2021-0005; Alternatives Research and Development Foundation, ARDF; University of Michigan, U-M; Russian Foundation for Basic Research, РФФИ: 19-29-08037; Russian Science Foundation, RSFThis research was partly supported by grant # 22-13-00298 of the Russian Science Foundation and IPAC RAS State Targets Project # FFSN-2021-0005; quantum-chemical calculations were supported the IBCP RAS State Targets Project # 122041400110-4. The synthesis of the compounds was financially supported by the Russian Foundation for Basic Research (research project # 19-29-08037). Support for RR’s contributions to the computer modeling components of the work was provided in part by a grant from the Alternatives Research and Development Foundation (ARDF) and an Mcubed grant from the University of Michigan

Core Proteome of the Minimal Cell: Comparative Proteomics of Three Mollicute Species

Mollicutes (mycoplasmas) have been recognized as highly evolved prokaryotes with an extremely small genome size and very limited coding capacity. Thus, they may serve as a model of a ‘minimal cell’: a cell with the lowest possible number of genes yet capable of autonomous self-replication. We present the results of a comparative analysis of proteomes of three mycoplasma species: A. laidlawii, M. gallisepticum, and M. mobile. The core proteome components found in the three mycoplasma species are involved in fundamental cellular processes which are necessary for the free living of cells. They include replication, transcription, translation, and minimal metabolism. The members of the proteome core seem to be tightly interconnected with a number of interactions forming core interactome whether or not additional species-specific proteins are located on the periphery. We also obtained a genome core of the respective organisms and compared it with the proteome core. It was found that the genome core encodes 73 more proteins than the proteome core. Apart of proteins which may not be identified due to technical limitations, there are 24 proteins that seem to not be expressed under the optimal conditions

Features of motivation of regional economy subjects to innovative activity

An important scientific and practical problem is investigated - the identification of the peculiarities of the motivation of regional economic entities to innovative activities. The presence of a pronounced correlation between the innovative activity of stakeholders and the degree of their motivation is established. It is proved that for the intensification of innovative processes it is important to consider and diagnose the internal motivation of stakeholder groups. The study substantiates the need to create conditions for the realization of group interests of stakeholders with their participation in innovation. It is concluded that it is necessary to develop systems for motivating stackers to innovative activities that fully take into account their group interests. It has been proved that effective innovation in the region is impossible without creating a system of methods and techniques of motivation that is adequate to the interests of stakeholder groups. Such a motivation system should be an integral element of the strategy of innovative transformations at the regional level. The study conducted by the authors allowed us to conclude that it is necessary to develop and put into practice methods and techniques for motivating stakeholder groups to innovative activities. The expediency of applying such methods as institutional, economic and organizational as part of the motivation system is proved, and the most promising methods of motivation are highlighted. It is important that the choice of a specific method and the method of motivation depends largely on the specifics of the group interests of stakeholders. The more fully they will be able to realize their interests in the process of innovative activity, the higher will be the degree of their innovative activity. The correspondence of the proposed methods of motivation of the possibility of achieving the group interests of stakeholders is analyzed

Innovative Development of a Human-Centered Economy in the Context of Overcoming the Pandemic

The article examines the theoretical and practical aspects of the innovative development of the human-centered economy in the context of overcoming the pandemic. The relevance of the study is confirmed by the fact that the world of high technologies, accelerated development and violent digitalization creates new rules of life. To the traditional risks that influenced humanity and caused crises in the past, the study adds new ones related to privacy of personal data and cybersecurity, artificial intelligence and new jobs, instant information dissemination and manipulation of public opinion, inequality of opportunities and environmental threats. It is concluded that the pandemic has become a powerful trigger for innovation. Social distancing technologies, which were especially popular during the coronavirus outbreak, are at the peak of demand. The pandemic has also adjusted the logic of providing government support to technology entrepreneurs. Among the priorities is support for domestic digital services that improve the quality of life online and provide social distancing. In conclusion, it was concluded that each crisis is unique, just as unique are the recipes for overcoming it, and each new wave brings new recipes to the entrepreneur and investor's piggy bank of how to build a sustainable business that is not afraid of threats of any type - from financial to biological. To protect oneself technologically from the shocks associated with the crisis, maximum digitalization of business processes and the use of modern business models, industrial automation using industrial Internet technologies, predictive analytics, the use of the most modern digital sales channels, and investments in personnel development are required. These and many other factors make up a modern sustainable business model

The Estimation of the Potential for Using Smart-Trackers as a Part of a Medical Indoor-Positioning System

This research aims to estimate the feasibility of using smart-bracelets as a part of a medicine indoor-positioning system, to monitor the health status and location of patients in a hospital. The smart-bracelet takes on the role of a token of the system and can measure pulse, blood pressure and saturation and provide data transmission over the BLE. The distance between token and anchor was calculated by the RSSI. The position of a token and anchor relative to each other was determined by the trilateration method. The results of the research showed that the accuracy of the developed system in a static position is 1.46 m and exceeds 3 m in a dynamic position. Results of experiments showed that measurements from the smart bracelets are transmitted to the server of the system without distortion. The study results indicated that smart-bracelets could be used to locate patients inside a hospital or estimate their current health state. Given the low accuracy of systolic pressure measurement, it is recommended to develop an algorithm that will allow smooth measuring error for higher-precision estimation of the patient’s general health state. In addition, it is planned to improve the positioning algorithm

The Estimation of the Potential for Using Smart-Trackers as a Part of a Medical Indoor-Positioning System

This research aims to estimate the feasibility of using smart-bracelets as a part of a medicine indoor-positioning system, to monitor the health status and location of patients in a hospital. The smart-bracelet takes on the role of a token of the system and can measure pulse, blood pressure and saturation and provide data transmission over the BLE. The distance between token and anchor was calculated by the RSSI. The position of a token and anchor relative to each other was determined by the trilateration method. The results of the research showed that the accuracy of the developed system in a static position is 1.46 m and exceeds 3 m in a dynamic position. Results of experiments showed that measurements from the smart bracelets are transmitted to the server of the system without distortion. The study results indicated that smart-bracelets could be used to locate patients inside a hospital or estimate their current health state. Given the low accuracy of systolic pressure measurement, it is recommended to develop an algorithm that will allow smooth measuring error for higher-precision estimation of the patient’s general health state. In addition, it is planned to improve the positioning algorithm