Protective Effects of Berberis Vulgaris Plant Extract on Paracetamol-induced Liver Toxicity in Rats

INTRODUCTION: Berberis vulgaris extract is known to be protective against many damages due to its anti-inflamatory and antioxidant properties. Paracetamol toxicity is one of the most common toxicities. In our study, we aimed to reduce the damage caused by paracetamol toxicity with the beneficial effects of Berberis vullgaris extract. METHODS: In our study, 42 Sprague Dawley 8-week-old rats were used. 7 groups were formed with 6 female animals in each group. At the 24th hour of the study, all groups underwent laparotomy under anesthesia and liver dissection was performed. Hematoxylin and Eosin (H&E) staining was used to evaluate liver histopathology, and PAS staining was used to show glycogen and basement membrane staining in liver tissue. In addition, scoring was done by showing apoptotic cells with TUNEL stain RESULTS: Hepatic degeneration and peritubular inflammation were quite evident in the groups to which we applied paracetamol. In this study, we observed that the number of positive cells increased in the group given paracetamol in TUNEL staining. As a result of the PAS staining we performed, glycogen accumulation in the hepatocytes of the group we induced with paracetamol was remarkable. DISCUSSION AND CONCLUSION: Berberis vulgaris plant extract appears to reduce Paracetamol-induced hepatic toxicity. As a result of the PAS staining, glycogen accumulation in the hepatocytes was remarkable in the group which was induced with paracetamol. Further studies are required for the use of determined molecules of Berberis vulgaris plant extract against the hepatotoxic effect of paracetamol in paracetamol toxicity

Laboratuvardan Kliniğe Transplantasyon Pratiği

Transplantasyon; Temel Tıbbi Bilimler, Moleküler Tıp, Genetik ve İmmünolojiden klinik uygulamalardan destek alan multidisipliner bir tıp dalıdır. Temel bilimlerdeki başarılı çalışmaların kliniğe uygulanması, klinikte karşılaşılan sorunların da, oluşturulan deneysel hayvan modellerinde irdelenmesi, elde edilen bilgilerin klinik uygulamalara aktarılması; diğer deyişle tecrübelerin “Translational” özellikli olması günümüz transplantasyon çalışmalarında bir gerekliliktir. İmmün sistemin bileşenlerinin ve reaksiyonlarının iyi bilinmesi, hücreler arası ilişkilerde greftin reddi ya da kabul edilmesinin şartlarını doğru anlamak ve uygun laboratuvar yöntemleri ile klinik durumun aydınlatılması transplantasyonda stratejik önemdedir. Bu nedenle, klinik transplantasyon çalışmaları yapanlar temel bilimler bilgileri ile de donanımlı olmalıdırlar. Multidisipliner bir dal olma bilinci ile yapılan klinik transplantasyon çalışmalarında başarı yakalanmaktadır. Laboratuvardan Kliniğe Transplantasyon kitabımızda tüm yönleri ile transplantasyonun organizmaya etkileri ve bunların klinik sonuçlarını, çalışmalarımızın ışığında sunmayı ve tartışmayı hedefledik. Editör: Prof.Dr. Mesut İzzet TİTİZ Yardımcı Editör: Doç.Dr. Pınar AT

Minimum Miktarda Yağlama ile İşlemede CuO Nanoakışkanın Etkisinin Araştırılması

Nanofluid is a new class of fluids engineered by dispersing nanometer-size solid particles into base fluids such as water, ethylene glycol, engine oil, cutting fluids, etc. Researches have shown that the thermal conductivity and the convection heat transfer coefficient of the fluid can be largely enhanced by the suspended nanoparticles. Recently, tribology research shows that lubricating oils with nanoparticle additives (MoS2, CuO, TiO2, Diamond, etc.) exhibit improved load-carrying capacity, antiwear and friction reduction properties. These features make the nanofluid very attractive in some cooling and/or lubricating application in many industries including manufacturing, transportation, energy, and electronics, etc. In this study, the effect of CuO nanofluid in minimum quantity lubrication machining was investigated

Dynamic Modeling of a Multiple Launch Rocket System

World Congress on Engineering (WCE 2015), JUL 01-03, 2015, Imperial Coll, London, ENGLAND, Int Assoc EngnMultiple Rocket Launcher Systems (MLRS) are used to aim rockets to the desired elevation (pitch) and azimuth (yaw) angles in order to hit targets. In this paper, a dynamic model for an MLRS with electromechanical actuators is presented along with performance evaluation of four different friction models. The final model is simulated and the results are compared with the test data taken from the real MLRS. The results show that the proposed model is accurate within, on average, 5% of the actual system

Attitudes of Australian and Turkish students of veterinary medicine toward nonhuman animals and their careers

We examined attitudes toward nonhuman animal welfare and rights and career aspirations in Australian and Turkish veterinary students. A representative university was selected in each country, with 190 first- and third-year students sampled in each. Survey questions addressed attitudes toward nonhuman animal welfare/rights, and intended career. Australian and Turkish students were predominately female and male, respectively, but attitudes were similar between sexes. Australian students rated keeping companion animals and hormonal desexing more acceptable, and food and rest deprivation, pain during slaughter, and using animals in experiments less acceptable than Turkish students. Keeping companion animals related strongly with students’ moral values, their decision to study veterinary medicine, and program satisfaction. More Australian than Turkish students wanted to enter clinical practice. Thus veterinary students of these two culturally contrasting countries demonstrated both differences and universalities, such as companion animal keeping, which influenced their attitudes toward animals and career aspirations.</p

Al2O3 Nanopartikül Kullanarak Metal Kesme İşleminin İyileştirilmesi

Recently, the scientific researches on nano-existing metalworking fluids consistently led to improvements in processing methods. Cooling and lubricating with the addition of particles of different particles, the fluid is a method of increasing the performance of the cutting tool. In recent years, conventional metalworking fluids involved in the nano-sized particles emerges as a new method. The fluids, in which these particles are added, is called as “nanofluids”. Inasmuch as the thermal conductivity of a solid metal is higher than that in the joined base from fluids, metallic particles increases the thermal conductivity of the fluid mixture into the join. This study examines the effects of Al2O3 nanofluids on the improvement of metal processing